Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting

Avvisati, Riccardo; Contu, Laura; Stendardo, Emiliana; Michetti, Caterina; Montanari, Christian; Scattoni, María Luisa; Badiani, Aldo

doi:10.1007/s00213-016-4247-4

Cited by 25 publications

(19 citation statements)

References 63 publications

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“…This suggests that the presence of a peer is not stressful, but rather reinforcing. Since it has been shown that cocaine by itself can induce the emission of positive USV (Avvisati et al, 2016), our results confirm that increased USV emissions here are more related to the presence of a peer than to cocaine itself.…”

Section: Is Social Presence a Stressor?supporting

confidence: 87%

Of Rats And Men: Peer Presence And Familiarity Are Key Factors Which Reduce Drug Intake

Giorla

Nordmann

Pelloux

et al. 2018

Preprint

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key words: Addiction, socioepidemiology, animal models, social factors, cocaine, stimulants word count (excluding abstract, references, tables, and figures) : 4800 declarations of competing interest : None of the authors has any possible conflict of interest to declare. 3 ABSTRACTSocial environment influences drug consumption, its persistence and evolution. Little is known regarding the influence of the presence of a peer during drug consumption and especially how the relationship between peers (familiarity and dominance) can influence drug consumption. We used here a translational and transdisciplinary approach to explore the influence of peer presence and peer familiarity in rats and humans that self-administer stimulants. In rats, cocaine intake was compared when rats were alone with intake when peers with different characteristics (familiar or not, cocaine naive or not, dominant or subordinate) were present. In humans, 77 cocaine and/or methylphenidate users were asked to detail their most recent drug use episodes and their relationship with peers present at consumption. The results show that in both humans and rats, the risk of cocaine/stimulant consumption was significantly reduced by 37% and 32%, respectively, when a peer was present. Moreover, the lowest risk of consumption was consistently observed when the peer was unfamiliar (vs familiar) with a further 38% and 17% risk reduction, respectively. In rats, a decreased risk of consumption was greater when the peer was cocaine naive (vs non-cocaine naive).The presence of a non-familiar and possibly drug-naive peer is the most efficient condition to diminish stimulant intake. Our results indirectly support the use of harm reduction strategies, in particular supervised consumption rooms for stimulant users.

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Section: Is Social Presence a Stressor?supporting

confidence: 87%

Of Rats And Men: Peer Presence And Familiarity Are Key Factors Which Reduce Drug Intake

Giorla

Nordmann

Pelloux

et al. 2018

Preprint

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“…Although the functional significance of these differences remains to be fully explored, they might have implications for both research and treatment. It is remarkable, for example, that the functional or anatomic integrity of the dopaminergic system is required for the reinforcing properties of cocaine but not of heroin (Ettenberg et al, 1982;Pettit et al, 1984;Pisanu et al, 2015), that distinct projections from the PFC to the shell of the NAcc are implicated in the relapse to cocaine versus heroin seeking after abstinence (Peters et al, 2008;Bossert et al, 2012), and that basic environmental manipulations gate in opposite directions the reinforcing, affective, and neurobiological responses to heroin versus cocaine in rats and humans (Uslaner et al, 2001;Ferguson et al, 2004;Caprioli et al, 2007aCaprioli et al, , 2008Caprioli et al, , 2009Paolone et al, 2007;Celentano et al, 2009;Montanari et al, 2015;Avvisati et al, 2016;De Pirro et al, 2018;De Luca et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Distinct Populations of Neurons Activated by Heroin and Cocaine in the Striatum as Assessed by catFISH

Vassilev

Avvisati

Koya

et al. 2020

eNeuro

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Despite the still prevailing notion of a shared substrate of action for all addictive drugs, there is evidence suggesting that opioid and psychostimulant drugs differ substantially in terms of their neurobiological and behavioral effects. These differences may reflect separate neural circuits engaged by the two drugs. Here we used the catFISH (cellular compartment analysis of temporal activity by fluorescence in situ hybridization) technique to investigate the degree of overlap between neurons engaged by heroin versus cocaine in adult male Sprague Dawley rats. The catFISH technique is a within-subject procedure that takes advantage of the different transcriptional time course of the immediate-early genes homer 1a and arc to determine to what extent two stimuli separated by an interval of 25 min engage the same neuronal population. We found that throughout the striatal complex the neuronal populations activated by noncontingent intravenous injections of cocaine (800 g/kg) and heroin (100 and 200 g/kg), administered at an interval of 25 min from each other, overlapped to a much lesser extent than in the case of two injections of cocaine (800 g/kg), also 25 min apart. The greatest reduction in overlap between populations activated by cocaine and heroin was in the dorsomedial and dorsolateral striatum (ϳ30% and ϳ22%, respectively, of the overlap observed for the sequence cocaine-cocaine). Our results point toward a significant separation between neuronal populations activated by heroin and cocaine in the striatal complex. We propose that our findings are a proof of concept that these two drugs are encoded differently in a brain area believed to be a common neurobiological substrate to drug abuse.

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“…In support of context facilitating in part the positive response following cocaine administration, a recent report showed that rats for whom the self-administration context was distinguished (i.e. Non-Resident) emitted significantly greater 50-kHz USVs during cocaine self-administration relative to Resident rats (Avvisati et al , 2016). These prior reports and our current findings support that psychostimulant-paired contexts elicit a strong subjectively-positive anticipatory response.…”

Section: Discussionmentioning

confidence: 99%

Comparing rewarding and reinforcing properties between ‘bath salt’ 3,4‐methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats

et al. 2016

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Abuse of synthetic psychostimulants like synthetic cathinones has risen in recent years. 3,4-Methylenedioxypyrovalerone (MDPV) is one such synthetic cathinone that demonstrates a mechanism of action similar to cocaine. Compared to cocaine, MDPV is more potent at blocking dopamine and norepinephrine reuptake and is readily self-administered by rodents. The present study compared the rewarding and reinforcing properties of MDPV and cocaine using systemic injection dose-response and self-administration models. Fifty kilohertz ultrasonic vocalizations (USVs) were recorded as an index of positive affect throughout experiments. In Experiment 1, MDPV and cocaine dose-dependently elicited 50-kHz USVs upon systemic injection, but MDPV increased USVs at greater rates and with greater persistence relative to cocaine. In Experiment 2, latency to begin MDPV self-administration was shorter than latency to begin cocaine self-administration, and self-administered MDPV elicited greater and more persistent rates of 50-kHz USVs versus cocaine. MDPV-elicited 50-kHz USVs were sustained over the course of drug load-up whereas cocaine-elicited USVs waned following initial infusions. Notably, we observed a robust presence of context-elicited 50-kHz USVs from both MDPV and cocaine self-administering rats. Collectively, these data suggest that MDPV has powerfully rewarding and reinforcing effects relative to cocaine at one-tenth doses. Consistent with prior work, we additionally interpret these data in supporting that MDPV has significant abuse risk based on its potency and subjectively positive effects. Future studies will be needed to better refine therapeutic strategies targeted at reducing the rewarding effects of cathinone analogs in efforts to ultimately reduce abuse liability.

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Ultrasonic vocalization in rats self-administering heroin and cocaine in different settings: evidence of substance-specific interactions between drug and setting

Cited by 25 publications

References 63 publications

Of Rats And Men: Peer Presence And Familiarity Are Key Factors Which Reduce Drug Intake

Of Rats And Men: Peer Presence And Familiarity Are Key Factors Which Reduce Drug Intake

Distinct Populations of Neurons Activated by Heroin and Cocaine in the Striatum as Assessed by catFISH

Comparing rewarding and reinforcing properties between ‘bath salt’ 3,4‐methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats

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