Preconditioning with atorvastatin against renal ischemia–reperfusion injury in nondiabetic versus diabetic rats

Hassan, Sherif S.; Rizk, A.; Thomann, Charity; Motawie, A G; Abd-Elfattah, S; Ahmad, Zulfiqar

doi:10.1139/cjpp-2018-0228

Cited by 13 publications

(8 citation statements)

References 38 publications

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“…Thus, the administration of antioxidants that counteract oxidative stress may protect kidneys from damage. Nephrotoxicity studies have confirmed the authentic roles of bioactive compounds to reduce chronic renal failure [27,[34][35][36]. The present study investigated CURC effects on OTA-induced toxicity using an in vivo animal model.…”

Section: Discussionmentioning

confidence: 72%

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

et al. 2020

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Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified, but it is supposed that oxidative stress is responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. CURC effects are examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. The end result of the experiment finds rats treated with OTA show alterations in biochemical and oxidative stress parameters in the kidney, related to a decrease in the Glomerular Filtration Rate (GFR). Conversely, the administration of CURC attenuates oxidative stress and prevents glomerular hyperfiltration versus the OTA group. Furthermore, kidney histological tests show a reduction in glomerular and tubular damage, inflammation and tubulointerstitial fibrosis. This study shows that CURC can mitigate OTA–induced oxidative damage in the kidneys of rats.

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Section: Discussionmentioning

confidence: 72%

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

et al. 2020

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“…30 Atorvastatin was administered at 10 mg/kg dose. 31 We used atorvastatin in our study to compare effects of 5-HT7 receptors with an anti-atherogenic agent in MI induced damage in rats with underlying atherosclerosis. All control rats received distilled injectable water as vehicle for all applications.…”

Section: Experimental Protocols Of Iso-induced MImentioning

confidence: 99%

The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction

et al. 2020

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The presence of 5-HT7r’s in both human and rat cardiovascular and immune tissues and their contribution to inflammatory conditions prompted us to hypothesize that these receptors contribute in acute myocardial infarction (MI) with underlying chronic endothelial dysfunction. We investigated the role of 5-HT7 receptors on heart tissue that damaged by isoproterenol (ISO)-induced MI in rats with high-fat diet (HFD). In vitro and in vivo effects of 5-HT7r agonist (LP44) and antagonist (SB269970) have been investigated on the H9C2 cell line and rats, respectively. For in vivo analyses, rats were fed with HFD for 8 weeks and after this period ISO-induced MI model has been applied to rat. To investigate the role of 5-HT7r’s, two different doses of LP44 and SB269970 were evaluated and compared with standard hypolipidemic agent, atorvastatin. In vitro studies showed that LP44 has protective and proliferative effects on rat cardiomyocytes. Also in in vivo studies stimulating 5-HT7r’s by LP44 improved blood lipid profile (decreased total cholesterol, low-density lipoprotein-C, and triglyceride, increased high-density lipoprotein), decreased cardiac damage markers (creatine kinase and troponin-I), and corrected inflammatory status (tumor necrosis factor-α, interleukin-6). Our results showed significant improvement in LP44 administered rats in terms of histopathologic analyses. In damaged tissues, 5-HT7 mRNA expression increased and agonist administration decreased this elevation significantly. We determined for the first time that 5-HT7r’s are overexpressed in ISO-induced MI of rats with underlying HFD-induced endothelial dysfunction. Restoration of this overexpression by LP44, a 5-HT7r agonist, ameliorated heart tissue in physiopathologic, enzymatic, and molecular level, showing the cardiac role of these receptors and suggesting them as future potential therapeutic targets.

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“…The CD44 and caspase-3 expression, oxidative stress, and kidney function biomarkers were improved in both groups. The study concluded that atorvastatin may have beneficial and protective effects on renal I/R injury in rats with or without diabetes [22].…”

Section: Resultsmentioning

confidence: 95%

Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus

Mashayekhi‐Sardoo

Atkin

Montecucco

et al. 2021

BioMed Research International

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Objective. Type 2 diabetes mellitus is a chronic metabolic disease caused by insulin resistance or insulin deficiency resulting in elevated blood glucose levels. Poorly controlled diabetes is associated with the development of cardiovascular disease and dyslipidemia. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statin) are an important class of therapeutic agents used to control hyperlipidemia and prevent cardiovascular disease in diabetic and nondiabetic patients. Since the effect of diabetes on the pharmacokinetics and pharmacodynamics of drugs and toxins has been shown, the aim was to review previous studies on the efficacy of statins such as atorvastatin, simvastatin, pravastatin, pitavastatin, fluvastatin, and rosuvastatin in clinical and preclinical studies in both diabetic and nondiabetic groups. Method. For this purpose, Web of Science, PubMed, Scopus, and Google Scholar databases were reviewed, and related English articles published until October 2020 were included in this review article. Results. The findings revealed that diabetes affected statin effectiveness through changes in pharmacokinetic parameters such as clearance and biotransformation biomarkers at mRNA and protein levels. Plasma and serum concentrations of statins were accompanied by alteration in cellular activities including oxidative stress, Akt inhibition, and endothelial nitric oxide synthase (eNOS) and phosphorylation that were reflected in changes in the adverse drug reaction profile of the differing statins. Conclusion. Given that dyslipidemia frequently accompanies diabetes and statin therapy is common, more clinical studies are needed regarding the effects of diabetes on the effectiveness of these drugs.

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Preconditioning with atorvastatin against renal ischemia–reperfusion injury in nondiabetic versus diabetic rats

Cited by 13 publications

References 38 publications

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction

Potential Alteration of Statin-Related Pharmacological Features in Diabetes Mellitus

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