Preconceptional folic acid‐containing supplement use in the national birth defects prevention study

Khodr, Zeina G.; Lupo, Philip J.; Agopian, A. J.; Canfield, Mark A.; Case, Amy P.; Carmichael, Suzan L.; Mitchell, Laura E.

doi:10.1002/bdra.23238

Cited by 21 publications

(15 citation statements)

References 22 publications

(33 reference statements)

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“…[23][24][25] In one recent population-based study, education, race/ethnicity, and age were the most distinguishing factors that described folic acid supplementation use. 26 We observed similar patterns in both our cases and controls. In our study, 45% of at-risk mothers reported starting folic acid supplementation during or after the first trimester.…”

Section: Discussionsupporting

confidence: 82%

Preconceptual Folic Acid Use and Recurrence Risk Counseling for Congenital Heart Disease

et al. 2014

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Objective Recurrence risk of congenital heart disease (CHD) in families with an affected first-degree relative is increased as compared to the general population. Advances in genetic testing and evidence that preconceptual folic acid supplementation may decrease risk of CHD, warrants preventative counseling for at-risk families. Our goal was to document patterns of preconceptual folic acid supplementation and recurrence risk counseling in at-risk families in order to identify opportunities for improved preventative care. Design Mothers referred for a fetal echocardiogram were prospectively enrolled. Cases were defined as mothers deemed to be at higher risk of having an affected fetus with CHD given an affected parent or affected previous pregnancy with CHD. Controls were defined as mothers with no prenatal risk factors. Mothers completed a validated questionnaire assessing use of folic acid supplementation and receipt of recurrence risk counseling. Chi-square analyses were performed to analyze questionnaire responses and demographic data. Results 314 subjects participated (controls= 216, cases= 98). Cases took preconceptual folic acid supplementation more often than controls (p<0.001), but only 55% started preconceptually. Maternal advanced education and counseling (p<0.001) were associated with preconceptual supplementation, whereas complexity of CHD in the relative was not. While 70% of cases received some recurrence risk counseling, those with advanced education and complex CHD in the affected relative were more likely to receive counseling. Few at-risk cases interacted with genetic services (19%). Conclusions At- risk mothers with lower education are less likely to take preconceptual folic acid supplementation or receive recurrence risk counseling. Healthcare providers should proactively provide this information to all at-risk patients and develop collaborations with genetic services.

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Section: Discussionsupporting

confidence: 82%

Preconceptual Folic Acid Use and Recurrence Risk Counseling for Congenital Heart Disease

et al. 2014

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“…For the purpose of this survey we have intentionally selected women with higher education since several studies revealed that such population is most compliant with recommendation of folacin supplementation [15,33]. This data suggests that efficacy of the folic acid education campaign in women without university education can be even less satisfactory.…”

Section: Discussionmentioning

confidence: 99%

Intake of folic acid by Polish women with higher education — a survey research: can we do more?

Pietrzykowska-Kuncman¹,

Zasina-Olaszek

Łukasz

et al. 2017

Ginekol Pol

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Objectives: The objective of the study is to determine efficacy of the Primary Prevention Program of Neural Tube Defects in Polish women with higher education in 5-year interval. Material and methods:Survey research was conducted twice (in 2008 and 2013) in 630 female students of universities: 305 female medical students and 325 female non-medical students. The survey was also done among women aged 27--35 who graduated from medical or non-medical universities and have at least one child. Questions concerned knowledge about prophylaxis and periconceptional folic acid intake. Chi square test was used to assess the significance. There was no significant difference in preconceptional folic acid intake among mothers with medical and non-medical education (53.3% vs. 45% p = 0.4). However, the highest folic acid intake was among mothers -medical doctors who treat children with neural tube defect. Conclusions:Difference between medical and non-medical students shows that better educational programs may improve knowledge about prophylaxis. Aside from knowledge, compliance with recommendations of Primary Prevention Program of Neural Tube Defects is unsatisfactory.

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“…Apart from race/ethnicity, factors associated with preconception folic acid use among women of child‐bearing age are well researched in the past. Studies have reported lower use among women who were younger, less than high school educated, unmarried, received WIC benefits, had a low family income, had a public insurance or no insurance, had a previous live birth, smokers, or those who used alcohol before pregnancy, did not intend to be pregnant at the time of index pregnancy (McDonnell et al, ; Chacko et al, ; Green‐Raleigh et al, ; D'Angelo et al, ; Khodr et al, ; Robbins et al, ; Bixenstine et al, ). Our results are consistent with findings from these previous studies.…”

Section: Discussionmentioning

confidence: 99%

Race and ethnicity and preconception folic acid supplement use among pregnant women in Georgia, PRAMS 2009 to 2011

Mukhtar

Kramer

Oakley

et al. 2017

Birth Defects Research

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Hispanics are a growing population in the United States with an expected 14 million women of child-bearing age by 2020, and the prevalence of preconception folic acid supplement use is low in this group with a high risk of neural tube defects. Promotion of voluntarily fortified corn masa flour can lower neural tube defects in Hispanics. Mandatory corn masa fortification will be a more effective public health policy.Birth Defects Research 109:38-48, 2017. © 2016 Wiley Periodicals, Inc.

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Preconceptional folic acid‐containing supplement use in the national birth defects prevention study

Cited by 21 publications

References 22 publications

Preconceptual Folic Acid Use and Recurrence Risk Counseling for Congenital Heart Disease

Preconceptual Folic Acid Use and Recurrence Risk Counseling for Congenital Heart Disease

Intake of folic acid by Polish women with higher education — a survey research: can we do more?

Race and ethnicity and preconception folic acid supplement use among pregnant women in Georgia, PRAMS 2009 to 2011

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