Preconception Hemoglobin and Ferritin Concentrations Are Associated with Pregnancy Outcome in a Prospective Cohort of Chinese Women

Ronnenberg, Alayne G.; Wood, Richard J.; Wang, Xiaobin; Huang, Xing; Chen, Chanzhong; Chen, Dafang; Guang, Wenwei; Huang, Aiqun; Wang, Lihua; Xu, Xiping

doi:10.1093/jn/134.10.2586

Cited by 121 publications

(120 citation statements)

References 35 publications

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“…The limitation is the change in eating habits of people depending on seasonal variances, which was disregarded in our study. As was shown in an earlier study (30), it may cause some oscillations in serum micronutrient levels.…”

Section: Discussionsupporting

confidence: 58%

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Karabulut¹,

Güler²,

Karahan³

et al. 2015

Turk J Med Sci

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Background/aim: Iron, folate, and vitamin B12 serum levels are closely related with dietary habits and have an essential role in the healthy development of a fetus. We aimed to investigate hemoglobin, ferritin, folate, and vitamin B12 levels in preconceptional women in an area where a plant-based diet referred to as Mediterranean cuisine is commonly used. Materials and methods:The study population included 466 women between the ages of 18 and 45 years admitted for thalassemia screening. Sociodemographic variables and history of menometrorrhagia, pica, and dietary habits were collected. Serum vitamin B12, folate, ferritin, and hemoglobin levels were measured. Ferritin of <12 µg/L, vitamin B12 of <200 pg/mL, and folate of <4 ng/mL were accepted as deficiencies. Hemoglobin level of <12 g/dL was classified as anemia.Results: Polymenorrhea was present in 11.7% and hypermenorrhea in 24.8% of women. Anemia was detected in 24.9% and thalassemia trait in 3.0% of women. Low ferritin levels were observed in 46.1%, vitamin B12 in 21.6%, and folate in 3.4% of women. In the group with low vitamin B12, decreased meat consumption was more prevalent (27.5% vs. 16.9%; P = 0.019). Conclusion:Vitamin B12 and iron are the main micronutrients depleted in our community. This necessitates implementing a public health program for women consuming a Mediterranean diet.

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Section: Discussionsupporting

confidence: 58%

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Karabulut¹,

Güler²,

Karahan³

et al. 2015

Turk J Med Sci

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“…However, substantial iron deficiency anemia (usually <80g/L) is associated with an increased incidence of LBW. The mechanism by which anemia could produce this effect is unknown, but other nutrient deficiencies are important contributing factors [10]. One study even reported harmful effects of iron supplementation [11].…”

Section: Discussionmentioning

confidence: 99%

Maternal Factors for Low Birth Weight Babies

Singh

Chouhan²,

Sidhu³

2009

Medical Journal Armed Forces India

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Introduction L ow birth weight (LBW) is the dominating risk factorfor infant morbidity and mortality, (36% of all mortality in children <5 years of age), constituting about 4 million deaths per year. Some term and preterm small babies are healthy, with weight and length according to their genetic potential, while others are smaller due to factors impeding growth during fetal life. This phenomenon is called intrauterine growth restriction (IUGR) and is the second leading cause of perinatal morbidity and mortality, after prematurity.Low birth weight lower than that expected from the genetic potential might be caused by fetal, maternal or placental factors or a combination of risk factors, resulting in an impaired placental transport of nutrients or reduced growth potential of the fetus. Constitutional, gender and hereditary factors explain up to 40% of the variability of birth weight. Maternal age (<20 or >35 yrs), ethnicity, marital status, birth interval, educational level and socio-economic conditions are other explanatory factors. Common fetal factors are genetic and/or chromosomal aberrations. Medical risk factors for LBW before pregnancy are chronic conditions like hypertension, renal insufficiency, cardio-respiratory, autoimmune, endocrine or infectious disorders. The risk factors for LBW during pregnancy are hypertensive disorders, diabetes, malnutrition, bleeding, anemia, infection, placental or fetal anomalies and multiple pregnancies. The morbidities of term and moderately preterm (>32 weeks) LBW are mainly related to uteroplacental insufficiency and poor energy substrate transfer, resulting in neonatal complications like birth asphyxia, hypothermia, meconium aspiration, polycythaemia, hypoglycemia, hypocalcaemia and thrombocythaemia.LBW infants are forty times more likely to die within their first four weeks of life than normal birth weight infants. LBW infants are also three times more likely than normal birth weight infants to have neurodevelopmental complications and congenital abnormalities [1].The neonatal course in LBW infants born preterm (<32 weeks) is dominated by complications caused by anatomic and physiological immaturity e.g. birth asphyxia, hypothermia, respiratory distress due to delayed alveolar clearance of water and surfactant deficiency, delayed postnatal circulatory adaptation with pulmonary hypertension, systemic hypotension and delayed closure of fetal shunts. Immaturity and reduced substrate stores explain high prevalence of hypo/ hyperglycemia, jaundice and coagulopathy. Immature Maternal Factors for Low Birth Weight BabiesLt Col G Singh * , Capt R Chouhan + , Maj K Sidhu # Abstract Background: Low birth weight is defined as the live births with less than 2.5 kg weight. It is a key determinant of infant survival, health and development. Low birth weight infants are at a greater risk of having a disability and for diseases such as cerebral palsy, visual problems, learning disabilities and respiratory problems. To reduce the low birth weight deliveries, we studied the maternal fac...

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“…However, a number of studies have revealed an increased risk of low birth weight (7)(8)(9)12,36), preterm birth (7,8,36) and stillbirth (10,11) associated with anemia in pregnancy. The results of past studies greatly depend on the definition of anemia, the time when hemoglobin was measured and potential confounders used for adjustment.…”

Section: Discussionmentioning

confidence: 99%

“…In China, low hemoglobin concentration was associated with increased risk for preterm birth, small-for-gestational-age foetuses and low birth weight (8). Women with anemia had infants who were at higher risk of having a low birth weight and foetal growth restrictions than infants born to non-anemic women (9). Anemia was also associated with a higher risk of stillbirth (10,11).…”

Section: Introductionmentioning

confidence: 99%

Anemia in pregnancy and its association with pregnancy outcomes in the Arctic Russian town of Monchegorsk, 1973–2002

Chumak

Grijbovski

2010

International Journal of Circumpolar Health

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Objectives. The purpose of this study was to determine the prevalence of anemia in pregnancy in Monchegorsk, north-west Russia, and to analyse its association with birth weight and the risk of stillbirth and preterm birth. Study design. A registry study based on the Kola Birth Registry. Methods. A total of 24,525 women who gave birth in Monchegorsk between 1973 and 2002 and who had data on anemia in pregnancy in the Kola Birth Registry (KBR) were included in the study. For these women, data on maternal anemia, age, occupation, marital status, parity, smoking, alcohol, gestational age, birth weight, stillbirth and year of delivery were obtained from the KBR. Linear regression was used to study the effect of maternal anemia on birth weight. Logistic regression was used to estimate the effect of anemia on the risks of stillbirth and preterm birth, with adjustment for the above-mentioned characteristics. Crude and adjusted odds ratios (OR) were calculated. Results. The prevalence of anemia increased from 43.7% in the 1970s to 89.8% in the beginning of the 2000s. Infants born to women with anemia were 48 grams (95% CI 36, 59) heavier than infants of non-anemic women. Women with anemia in pregnancy were less likely to have stillbirths (OR=0.68; 95% CI 0.52, 0.89) and preterm births (OR=0.66; 95% CI 0.58, 0.75) after adjustment for potential confounders. Conclusion. The prevalence of anemia in pregnant women as defined by the KBR more than doubled during the 30-year period. Positive associations with birth weight and negative associations with the risk of stillbirth and live preterm birth were observed.

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Preconception Hemoglobin and Ferritin Concentrations Are Associated with Pregnancy Outcome in a Prospective Cohort of Chinese Women

Cited by 121 publications

References 35 publications

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Premarital screening of 466 Mediterranean women for serum ferritin,vitamin B12, and folate concentrations

Maternal Factors for Low Birth Weight Babies

Anemia in pregnancy and its association with pregnancy outcomes in the Arctic Russian town of Monchegorsk, 1973–2002

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