Precocene II causes atrophy of corpora allata in Locusta migratoria

Pener, M. P.; Orshan, Laor; Wilde, Jim C. H.

doi:10.1038/272350a0

Cited by 107 publications

(33 citation statements)

References 3 publications

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“…101,104) Precocenes proved to inhibit JH biosynthesis and secretion in O. fasciatus and several hemimetabolous species because of their cytotoxic effect to cells of corpora allata. 104,105) Precocenes have little effect on the metamorphosis of holometabolous insects, except these compounds affect the oocyte development in Drosophila 106) and cause precocious adult development in Spodoptera. 107,108) Attempts have been made to increase the potency and enlarge the spectrum of the natural precocenes, but have not been very successful.…”

Section: Discovery Of Precocenesmentioning

confidence: 99%

Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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Juvenile hormone (JH) is a sesquiterpenoid hormone that regulates growth and development in insects. Since JH is a hormone specific to insects and other arthropods, compounds disrupting JH action in insects are expected to be ideal insecticides with low toxicity to non-target organisms. Many natural or synthetic analogs with JH-like or anti-JH activity have been identified, and some potent JH mimics have been used as insecticides. Recent studies on the enzymes in JH biosynthetic and metabolic pathways should be helpful for the discovery of more potent analogs and for the establishment of new means of pest management using recombinant DNA technology. © Pesticide Science Society of Japan Keywords: juvenile hormone (JH), insect metamorphosis, insect growth regulators, biosynthesis and metabolism of JH. Review* To whom correspondence should be addressed. E-mail: chieka_minakuchi@yahoo.com © Pesticide Science Society of Japan doptera. 17,18) Higher Diptera such as D. melanogaster and the blowfly Calliphora vomitoria produce JH III bisepoxide. 19,20) A small amount of methyl farnesoate, a precursor of JH III, was found in cockroach embryos and larvae. [20][21][22] Methyl farnesoate has also been identified in crustaceans 23) and is thought to have a JH-like action in female reproduction. 24)12Ј-OH JH III identified from the corpora allata of the African locust Locusta migratoria migratorioides was reported to exhibit JH activity when a high dose of this compound was topically applied to Tenebrio pupae. 25,26) Biosynthesis, Transport and Metabolism of Juvenile HormoneIn insects, JH is synthesized in the corpora allata via the mevalonate pathway (Fig. 2).27) The mevalonate pathway also exists in mammals and plants, and the early steps from acetylCoA to farnesyl diphosphate are conserved among these organisms. Importantly, insects and other arthropods do not synthesize cholesterol de novo but have to acquire it from dietary sources because they lack the genes encoding squalene synthase and other subsequent enzymes of the sterol branch. 28,29) Another peculiarity of the mevalonate pathway in insects is the capacity to synthesize JH via the isoprenoid branch.The genes encoding the enzymes in the mevalonate pathway from acetyl-CoA to farnesyl diphosphate have been identified in the genome of D. melanogaster and the malaria mosquito Anopheles gambiae, and in an EST library of the pine engraver Ips pini.27) However, it has been difficult to identify the genes encoding enzymes from farnesyl diphosphate to JH

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Section: Discovery Of Precocenesmentioning

confidence: 99%

Insect juvenile hormone action as a potential target of pest management

Minakuchi

Riddiford

2006

J. Pestic. Sci.

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“…Experimental animals were either chemically allatectomised by using precocene (7-ethoxy-6-methoxy-2,2-dimethylchromene; Sigma) or surgically allatectomised by removing the corpora allata. Precocene (500·µg/animal, dissolved in 10·µl acetone), which chemically inactivates the corpora allata (Bowers et al, 1976;Pener et al, 1978) was topically applied onto the dorsal neck fold once at the day of adult emergence. Control animals were treated with acetone only.…”

Section: Hormonal Manipulationmentioning

confidence: 99%

Morphological and functional maturation of a skeletal muscle regulated by juvenile hormone

Rose

2004

Journal of Experimental Biology

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“…For example, the antifeedant azadirachtin caused growth disruption in insects, possibly by interfering with normal hormone balance [12]. The earlier reports [3,4,6 ] of precocious adult formation in precocene treated hem im etabolous insects could possibly be due to its antifeeding action. However, this hormonal disturbance was not observed in the honey bee, a holometabolous insect.…”

Section: Resultsmentioning

confidence: 99%

“…O f the two related compounds, 6,7-dimethoxy-2,2-dimethylchromene (Precocene II) was more active than the cor responding 7-methoxy compound (Precocene I). Pre cocene II inhibited JH biosynthesis by cockroach corpora allata (CA) in vitro [5], and caused atrophy of CA in Locusta migratoria [6 ]; it was even called a "chemical allatectom izer" for Apis mellifera [7].…”

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confidence: 99%

Precocene II is no Anti-Juvenile Hormone in the Honey Bee, Apis mellifera

Rembold

Czoppelt

Sharma

1979

Zeitschrift Für Naturforschung C

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The effect o f precocene II on development o f the honey bee, Apis mellifera, was studied in vitro. One-to two-day-old worker larvae (body weight 0.5 -1.0 mg) were removed from the colonies, reared on royal jelly-yeast extract, and after 24 h were topically applied with different amounts (5 -75 |ig/larva) of precocene II. Toxicity was observed only with precocene doses o f 50 (ag/larva and more. The larval weight-gains declined with the increase o f doses. The acetone-treated control had better survival and weight-gain as compared to the no-treatment control. The larval and pu pal periods in the treated larvae remained unchanged as compared to the controls. The possibility of precocene acting as an antifeedant is discussed.

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Precocene II causes atrophy of corpora allata in Locusta migratoria

Cited by 107 publications

References 3 publications

Insect juvenile hormone action as a potential target of pest management

Insect juvenile hormone action as a potential target of pest management

Morphological and functional maturation of a skeletal muscle regulated by juvenile hormone

Precocene II is no Anti-Juvenile Hormone in the Honey Bee, Apis mellifera

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