Preclinical toxicological assessment of a phytotherapeutic product – CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.)

Tabach, Ricardo; Rodrigues, Eliana; Carlini, E. A.

doi:10.1002/ptr.2499

Cited by 20 publications

(18 citation statements)

References 32 publications

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“…Our study also demonstrated that the TA98 strain, after extract metabolism by S9 fraction, induced a significant increase in number of revertant colonies, indicating that the chemical components of the extract, after undergoing metabolism, might form mutagenic products capable of inducing insertion and/or deletion of DNA base pairs (frameshift mutations). Tabach et al (2009) developed a preclinical toxicological evaluation of a phytotherapeutic product termed CPV, which consists of C. oxyacantha aerial part extract (26.7 %) in association with Passiflora incarnata (33.3 %) and Valeriana officinalis (40 %) extracts. Several parameters were investigated in their study including, teratogenicity, mutagenicity, and genotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…At present, few studies examined the genetic toxicity of C. oxyacantha extract. Tabach et al (2009) developed a preclinical toxicological assessment of a phytotherapeutic product-CPV, which consist of dry aerial parts of C. oxyacantha (26.7%), Passiflora incarnata (33.3%), and Valeriana officinalis (40%). The parameters assessed included weight, behavior, estrous cycle, teratogenicity in dogs, rats, or mice, and mutagenicity in bacteria (Ames test).…”

Section: Introductionmentioning

confidence: 99%

“…The parameters assessed included weight, behavior, estrous cycle, teratogenicity in dogs, rats, or mice, and mutagenicity in bacteria (Ames test). Tabach et al (2009) reported only negative results, indicating that the CPV mixture was apparently devoid of risk for humans.…”

Section: Introductionmentioning

confidence: 99%

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Fruit extract of the medicinal plant Crataegus oxyacantha exerts genotoxic and mutagenic effects in cultured cells

Quadros

Mazzeo

Marin-Morales

et al. 2017

Journal of Toxicology and Environmental Health, Part A

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Crataegus oxyacantha, a plant of the Rosaceae family also known "English hawthorn, haw, maybush, or whitethorn," has long been used for medicinal purposes such as digestive disorders, hyperlipidemia, dyspnea, inducing diuresis, and preventing kidney stones. However, the predominant use of this plant has been to treat cardiovascular disorders. Due to a lack of studies on the genotoxicity of C. oxyacantha, this investigation was undertaken to determine whether its fruit extract exerts cytotoxic, genotoxic, or clastogenic/aneugenic effects in leukocytes and HepG2 (liver hepatocellular carcinoma) cultured human cells, or mutagenic effects in TA100 and TA98 strains of Salmonella typhimurium bacterium. Genotoxicity analysis showed that the extract produced no marked genotoxic effects at concentrations of 2.5 or 5 µg/ml in either cell type; however, at concentrations of 10 µg/ml or higher significant DNA damage was detected. The micronucleus test also demonstrated that concentrations of 10 µg/ml or higher produced clastogenic/aneugenic responses. In the Ames test, the extract induced mutagenic effects in TA98 strain of S. typhimurium with metabolic activation at all tested concentrations (2.5 to 500 µg/ml). Data indicate that, under certain experimental conditions, the fruit extract of C. oxyacantha exerts genotoxic and clastogenic/aneugenic effects in cultured human cells, and with metabolism mutagenicity occurs in bacteria cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fruit extract of the medicinal plant Crataegus oxyacantha exerts genotoxic and mutagenic effects in cultured cells

Quadros

Mazzeo

Marin-Morales

et al. 2017

Journal of Toxicology and Environmental Health, Part A

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“…Various species of Passiflora have aphrodisiac activity [56-60], and Myristica fragrans as well as Syzygium aromaticum [61,62], and extracts of Lantana camara [63,64] and Pilea spp. [23] fulfil the same purpose, while Portulaca oleracea showed efficacy in relieving uterine bleeding [65,66].…”

Section: Discussionmentioning

confidence: 99%

Medicinal plants used in Northern Peru for reproductive problems and female health

Bussmann

Glenn

2010

J Ethnobiology Ethnomedicine

236

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Infections of the reproductive tract, complications after childbirth, and reproductive problems continue to be a major health challenge worldwide. An impressive number of plant species is traditionally used to remedy such afflictions, and some have been investigated for their efficacy with positive results. A total of 105 plant species belonging to 91 genera and 62 families were documented and identified as herbal remedies for reproductive problems in Northern Peru. Most species used were Asteraceae (9.52%), followed by Lamiaceae and Fabaceae (8.57% and 6.67%). The most important families are clearly represented very similarly to their overall importance in the local pharmacopoeia. The majority of herbal preparations for reproductive afflictions were prepared from the leaves of plants (22.72%), the whole plant (21.97%), and stems (21.21%), while other plant parts were used less frequently. More than 60% of the cases fresh plant material was used to prepare remedies. Over 70% of the remedies were applied orally, while the remaining ones were applied topically. Many remedies were prepared as mixtures of multiple ingredients.Little scientific evidence exists to prove the efficacy of the species employed as reproductive disorder remedies in Northern Peru. Only 34% of the plants found or their congeners have been studied at all for their medicinal properties. The information gained on frequently used traditional remedies might give some leads for future targets for further analysis in order to develop new drugs.

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“…Various species of Passiflora have aphrodisiac activity [488–491], and Myristica fragrans as well as Syzygium aromaticum [492], and extracts of Lantana camara [493, 494] and Pilea spp. [369] fulfil the same purpose, while Portulaca oleracea showed efficacy in relieving uterine bleeding [495, 496].…”

Section: Two Decades Of Traditional Medicine Research In Northern mentioning

confidence: 99%

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

Bussmann

2013

Evidence-Based Complementary and Alternative Medicine

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Northern Peru represents the center of the Andean “health axis,” with roots going back to traditional practices of Cupisnique culture (1000 BC). For more than a decade of research, semistructured interviews were conducted with healers, collectors, and sellers of medicinal plants. In addition, bioassays were carried out to evaluate the efficacy and toxicity of plants found. Most of the 510 species encountered were native to Peru (83%). Fifty percent of the plants used in colonial times have disappeared from the pharmacopoeia. Market vendors specialized either on common and exotic plants, plants for common ailments, and plants only used by healers or on plants with magical purposes. Over 974 preparations with up to 29 different ingredients were used to treat 164 health conditions. Almost 65% of the medicinal plants were applied in these mixtures. Antibacterial activity was confirmed in most plants used for infections. Twenty-four percent of the aqueous extracts and 76% of the ethanolic extracts showed toxicity. Traditional preparation methods take this into account when choosing the appropriate solvent for the preparation of a remedy. The increasing demand for medicinal species did not increase the cultivation of medicinal plants. Most species are wild collected, causing doubts about the sustainability of trade.

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Preclinical toxicological assessment of a phytotherapeutic product – CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.)

Cited by 20 publications

References 32 publications

Fruit extract of the medicinal plant Crataegus oxyacantha exerts genotoxic and mutagenic effects in cultured cells

Fruit extract of the medicinal plant Crataegus oxyacantha exerts genotoxic and mutagenic effects in cultured cells

Medicinal plants used in Northern Peru for reproductive problems and female health

The Globalization of Traditional Medicine in Northern Peru: From Shamanism to Molecules

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