Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment

Bernardes, Maria Tereza Carneiro Paschoal; Agostini, Sandra Barbosa Neder; Pereira, Gislaine Ribeiro; Silva, Laíla Pereira da; Silva, Jéssica Bassi da; Bruschi, Marcos Luciano; Novaes, Rômulo Dias; Carvalho, Flávia Chiva

doi:10.1016/j.ejps.2021.105956

Cited by 14 publications

(9 citation statements)

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“…Hydrogels, water-insoluble cross-linked hydrophilic polymers, have become a popular trend in psoriasis with/without nanoformulations lately, as they can improve anti-psoriatic activity after drug encapsulation. The gels can solely act as drug vehicles, 47 or formulated into nanostructured supramolecules, 48 or integrated as excipients in various types of nanocarriers, such as graphene oxide, 49 polymeric nanoparticles, 43 nanosponge, 50 and niosomes. 51 With the growing interest and research in hydrogels, it is expected that they would become a significant component of nano-based drug delivery systems in the future to further improve the therapeutic profiles.…”

Section: Introductionmentioning

confidence: 99%

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

et al. 2021

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“…This is because increased proportions of HPMC in the matrix resulted in a proportionate decrease in the amount of water uptake, leading to lesser drug release. EC, owing to its hydrophobic nature, produced a retarded drug release from the matrix [16]. The optimized F5 formulation showed a controlled-release pattern.…”

Section: Discussionmentioning

confidence: 96%

“…Studies have shown that diffusion rate is affected due to the physicochemical characteristics of the formulations. These include hydrogen bonding, drug loading capacity, surface charge and mode of application [16]. The skin permeation experiment concluded that patch formulations play a significant role in controlling methotrexate release, as well as drug targeting to the skin.…”

Section: Discussionmentioning

confidence: 99%

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Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo

et al. 2021

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Transdermal drug delivery systems (TDDSs) have become innovative, fascinating drug delivery methods intended for skin application to achieve systemic effects. TDDSs overcome the drawbacks associated with oral and parenteral routes of drug administration. The current investigation aimed to design, evaluate and optimize methotrexate (MTX)-loaded transdermal-type patches having ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) at different concentrations for the local management of psoriasis. In vitro release and ex vivo permeation studies were carried out for the formulated patches. Various formulations (F1–F9) were developed using different concentrations of HPMC and EC. The F1 formulation having a 1:1 polymer concentration ratio served as the control formulation. ATR–FTIR analysis was performed to study drug–polymer interactions, and it was found that the drug and polymers were compatible with each other. The formulated patches were further investigated for their physicochemical parameters, in vitro release and ex vivo diffusion characteristics. Different parameters, such as surface pH, physical appearance, thickness, weight uniformity, percent moisture absorption, percent moisture loss, folding endurance, skin irritation, stability and drug content uniformity, were studied. From the hydrophilic mixture, it was observed that viscosity has a direct influence on drug release. Among all formulated patches, the F5 formulation exhibited 82.71% drug release in a sustained-release fashion and followed an anomalous non-Fickian diffusion. The permeation data of the F5 formulation exhibited about a 36.55% cumulative amount of percent drug permeated. The skin showed high retention for the F5 formulation (15.1%). The stability study indicated that all prepared formulations had very good stability for a period of 180 days. Therefore, it was concluded from the present study that methotrexate-loaded transdermal patches with EC and HPMC as polymers at different concentrations suit TDDSs ideally and improve patient compliance for the local management of psoriasis.

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“…IP-MTX partially reduced and 0.1% SP-MTX barely affected IL-17A-producing γδ T cell. - Local AE: N/A - Systemic AE: No Topical MTX using liquid crystalline systems Bernandes et al (2021) 33 42 a) MTX-loaded lamellar liquid crystal systems daily b) MTX-loaded hexagonal liquid crystal systems daily c) MTX hydrogel daily d) 0.1% dexamethasone cream e) Negative control f) Imiquimod cream 5 days Clinical : Erythema improved in the groups a, c, d. Peeling improved in the groups c, d. The lesion area improved in the groups a, c, d and f Histology : Group a, b, f showed the higher thickening of the epidermis compared to c, d, e groups (P <0.05). Cytokines : Group a, b, f showed higher cyclooxygenase-2 and myeloperoxidase activity and prostaglandin-2 production compared to the c, d, e groups (P <0.05) Group a, b showed higher level of IL-1 and IFN-γ in the skin of animals when compared with group d, e, f - Local AE: N/A - Systemic AE: N/A Alves et al (2022) 31 35 a) Cholesterol/ceramide-based MTX-loaded liquid crystals daily b) Cholesterol-based MTX-loaded liquid crystals daily c) Dexamethasone acetate d) Negative control e) Imiquimod cream 3 weeks Clinical: - Histology : Both MTX-loaded liquid crystals formulation exhibited an increase in keratinization score, epidermis thickness, and inflammatory infiltrate.…”

Section: Methodsmentioning

confidence: 99%

The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review

Chaiyabutr¹,

Punnakitikashem²,

Silpa‐archa³

et al. 2022

CCID

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Methotrexate (MTX) has long been considered the first-line oral systemic pharmacotherapy for psoriasis. The drug has several well-known systemic side effects, such as bone marrow suppression and hepatotoxicity. To avoid them, the use of topical or intralesional administrations of MTX has become an interesting option. With the advent of novel drug delivery systems, especially nanocarriers, the usage of a high-efficacy and safe topical MTX for psoriasis has nearly been attained. This review examined the development, anti-psoriatic efficacy and adverse effects of topical forms of MTX (plain MTX; MTX with chemical enhancer; MTX using nanotechnology; MTX with protein transduction domains; MTX with liquid crystalline systems; and MTX with physical enhancer/laser) and intralesional MTX in psoriasis patients and psoriasis-induced animals. The efficacy of topical MTX varied with the drug delivery technology employed. Nevertheless, the overall safety profile of the topical forms was favourable. A 25 mg/mL MTX solution injected intralesionally at the nail matrix worked well for nail psoriasis recalcitrant to topical treatment. To improve the standard of care for patients with psoriasis, randomized controlled trials that establish the most effective MTX-delivery system are needed.

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Preclinical study of methotrexate-based hydrogels versus surfactant based liquid crystal systems on psoriasis treatment

Cited by 14 publications

References 50 publications

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects

Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo

The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review

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