Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features

Jucevičiūtė, Neringa; Banaitytė, Indrė; Vaitkus, Antanas; Balnytė, Renata

doi:10.1016/j.mehy.2019.04.013

Cited by 10 publications

(8 citation statements)

References 42 publications

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“…This hypothesis was supported by the result of a prospective study on 38,641 male and 93,661 female patients, which demonstrated that those with red hair are at higher risk of developing PD and the risk of PD decreases in individuals with darker hair [34]. Another study revealed that PD patients had a greater tendency to experience sunburn and found tanning more difficult [33]. It cannot be dismissed that both NMSCs and PD may share similar genetic pathways [8].…”

Section: Discussionmentioning

confidence: 96%

“…These two cancers mainly affect fair-skinned, redhaired, blue-eyed individuals, who have a high predilection to sun-induced skin lesions [9]. It was hypothesized that patients with PD may be more sensitive to UV due to genetically determined lower amounts of eumelanin in the skin [33]. This hypothesis was supported by the result of a prospective study on 38,641 male and 93,661 female patients, which demonstrated that those with red hair are at higher risk of developing PD and the risk of PD decreases in individuals with darker hair [34].…”

Section: Discussionmentioning

confidence: 99%

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Risk of Nonmelanoma Skin Cancers and Parkinson’s Disease—Meta-Analysis and Systematic Review

Krasowska

Gerkowicz

Mlak

et al. 2021

Cancers

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Patients with Parkinson’s disease (PD) have an increased risk of melanoma compared with the general population. Considering that Nonmelanoma Skin Cancers (NMSCs) share similar risk factors with melanoma, there is a need to understand a possible connection between PD and NMSCs. The aim of the study was the evaluation of NMSC risk among PD patients via meta-analysis and systematic review. A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted, including studies from January 2000 to April 2020. We identified 16 eligible studies including 140291 PD patients. Upon statistical analysis, a significantly higher risk of developing NMSCs in PD patients was found compared with the control group (odds ratio (OR) = 1.25, 95% CI: 1.17–1.33; p < 0.0001). Among all NMSCs, the risk of developing basal cell carcinoma in PD patients was significantly higher (OR = 1.30, 95% confidence interval (CI): 1.15–1.47; p < 0.0001), contrary to squamous cell carcinoma. Further analysis revealed a significantly higher risk of developing NMSCs in patients with previously diagnosed PD (OR = 1.26, 95% CI: 1.19–1.33; p < 0.0001). Our data suggest the necessity for regular skin examination of PD patients, though further studies are required to explore the mechanisms forming this relationship.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Risk of Nonmelanoma Skin Cancers and Parkinson’s Disease—Meta-Analysis and Systematic Review

Krasowska

Gerkowicz

Mlak

et al. 2021

Cancers

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“…Defects in ABCA12 and GCase cause marked skin barrier abnormalities; in severe cases, these are incompatible with terrestrial life 165 . It is noteworthy that patients with PD also experience sweating and skin problems; in some cases, their skin become very dry, rough, and wrinkled 201,202 . The possible role of GCase in such skin manifestations warrants further research.…”

Section: Lewy Pathologymentioning

confidence: 99%

The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease

2020

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A BS TRACT: Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and, consequently, motor control. Dopaminergic degeneration is associated with the appearance of Lewy bodies, which contain membrane structures and proteins, including α-synuclein (α-Syn), in surviving neurons. PD displays a multifactorial pathology and develops from interactions between multiple elements, such as age, environmental conditions, and genetics. Mutations in the GBA1 gene represent one of the major genetic risk factors for PD. This gene encodes an essential lysosomal enzyme called β-glucocerebrosidase (GCase), which is responsible for degrading the glycolipid glucocerebroside into glucose and ceramide. GCase can generate glucosylated cholesterol via transglucosylation and can also degrade the sterol glucoside. Although the molecular mechanisms that predispose an individual to neurodegeneration remain unknown, the role of cholesterol in PD pathology deserves consideration. Disturbed cellular cholesterol metabolism, as reflected by accumulation of lysosomal cholesterol in GBA1-associated PD cellular models, could contribute to changes in lipid rafts, which are necessary for synaptic localization and vesicle cycling and modulation of synaptic integrity. α-Syn has been implicated in the regulation of neuronal cholesterol, and cholesterol facilitates interactions between α-Syn oligomers. In this review, we integrate the results of previous studies and describe the cholesterol landscape in cellular homeostasis and neuronal function. We discuss its implication in α-Syn and Lewy body pathophysiological mechanisms underlying PD, focusing on the role of GCase and cholesterol.

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“…Enzymatic darkening during the harvest of fresh-cut vegetables and fruit, especially in mushrooms, is undesirable and reduces nutritional quality and the commercial value of the product [5]. Tyrosinase is also an enzyme involved in the production of neuromelanin and damaged neurons associated with Parkinson's disease [6,7]. For these reasons, tyrosinase inhibitors have potential practice areas in the food industry, medical and cosmetic products.…”

Section: Introductionmentioning

confidence: 99%

Antityrosinase Activities and in silico ADME Properties of Fluorine-containing 1,2,4-triazole-5-on Derivatives

Cakmak

Tuncay

2022

Hacettepe Journal of Biology and Chemistry

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Bu çalışmada, flor içeren 1,2,4-triazol-5-on türevlerinin (2a-b, 3a-b, 4a-d, 5a-b, 6a-b, 7a-b, 8a-b ve 9a-b) klinik öneme sahip tirosinaz enziminin aktivitesi üzerine inhibisyon potansiyelleri incelenmiştir. Moleküllerin IC50 değerleri belirlenmiştir. Moleküller arasında en iyi inhibisyon özelliği gösteren molekülün inhibisyon türü ve Ki değeri hesaplanmıştır. Ticari olarak temin edilen mantar tirosinaz için optimum reaksiyon şartları belirlendikten sonra, kinetik çalışmalar yapılarak en düşük IC50 değerine sahip molekülün 8b olduğu tespit edilmiştir. Referans inhibitör molekül olarak kullanılan kojik aside (IC50=45,7±0,9 µM) göre 8a-b, 9a-b (IC50 değerleri sırasıyla 32,2±0,7 µM; 22,9±0,6 µM; 22,8±0,5 µM; 23,8±0,6 µM) moleküllerinin tirosinaz aktivitesi üzerinde oldukça etkili inbitör özelliğine sahip olduğu tespit edilmiştir. 8b molekülü için inhibisyon türü nonkompetetif olarak belirlenmiş ve Ki değeri 6,09±0,12 µM olarak hesaplanmıştır. Ayrıca tüm moleküllerin ADME özellikleri de incelenmiş olup, her bir molekülün ilaç aday molekülü olarak yüksek bir potansiyele sahip olduğu tespit edilmiştir. Bu sonuçlar neticesinde 8a-b ve 9a-b molekülleri, tirosinaz aktivitesine karşı oldukça etkili ve umut verici inhibitör bileşikler olarak kabul edilebilir.

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Preclinical signs of Parkinson's disease: A possible association of Parkinson's disease with skin and hair features

Cited by 10 publications

References 42 publications

Risk of Nonmelanoma Skin Cancers and Parkinson’s Disease—Meta-Analysis and Systematic Review

Risk of Nonmelanoma Skin Cancers and Parkinson’s Disease—Meta-Analysis and Systematic Review

The Role of Cholesterol in α‐Synuclein and Lewy Body Pathology in GBA1 Parkinson's Disease

Antityrosinase Activities and in silico ADME Properties of Fluorine-containing 1,2,4-triazole-5-on Derivatives

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