Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats

Boas, Gustavo Roberto Villas; Santos, Ariany Carvalho dos; Souza, Roosevelt Isaías Carvalho; Araújo, Flávio Henrique Souza de; Traesel, Giseli Karenina; Marcelino, Jhony Moreira; Silveira, Ana Paula Stefanello da; Farinelli, Brunna Charlla Feitosa; Cardoso, Cláudia Andréa Lima; Lacerda, Roseli Boerngen de; Oesterreich, Silvia Aparecida

doi:10.1016/j.fct.2018.04.063

Cited by 19 publications

(6 citation statements)

References 34 publications

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“…In the present research, there were no deaths in any group and, although the weight gain was higher in the G4 group, the one treated by Campomanesia pubescens was not inferior to the others. In recent research on the toxicity of this herbal remedy , Villas Boas et al (2018), are shown to be safe enough to be tested in humans under conditions similar to those in which the animals were exposed.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the scientific activity of the leaf of the species Campomanesia pubescens in wound model infected by Staphylococcus aureus

et al. 2021

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There is an increasing interest in the use of herbal remedies as healing agents, due to their lower cost in relation to other drugs and the vast Brazilian fauna. The objective of this research was to evaluate the cicatrization effect of the guariroba leaf (Campomanesia pubescens) on the healing of infected wounds. We used 45 Wistar rats, distributed in five groups (n = 9) all with surgically induced skin injury, differing in the presence of contamination and treatment, with evaluation periods of 3, 7 and 14 days, being: G1- negative control without contamination, treated with Physiological Solution 0.9%; G2- control with contamination, treated with Physiological Solution 0.9%; G3 negative with contamination, treated with Carbopol in 0.5% gel; G4- positive control with contamination, treated with Colagenase at 0.6 U / g + 0.01 g Chloramphenicol; G5- positive test with contamination treated with Campomanesia pubescens at 3%, whose vehicle was Carbopol at 0.5%. The wound was made with a metal punch 8 mm in diameter, and a cutaneous fragment was removed from the animals' backs and wound infection was applied to S. aureus in groups G2 to G5. Euthanasia was performed for a lethal dose of anesthetic, and the edges of the wounds were removed for histopathological study. The fibrinoleukocytic crust was present in all animals in the groups of 3, 7 and 14 days. The contraction of the wound was also evaluated, and all groups showed low percentage of wound regression in the 3-day treatment and with 14 days presented a high percentage of regression. Of the 5 groups, the only one that presented complete epithelialization was G5. Of the 5 groups, the ones with the best epithelialization were G4 and G5. The group with the highest amount of mature collagen fibers was G4, followed by G5, and the one with the highest proportion of immature fibers was G1. At the end of the experiment, G4 was the group that gained the most weight and G1 the one that had the lowest weight gain. Guariroba leaf extract (Campomanesia pubescens) was able to promote healing in infected skin wounds similar to the group treated with antibiotics.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the scientific activity of the leaf of the species Campomanesia pubescens in wound model infected by Staphylococcus aureus

et al. 2021

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“…The ethanolic extract of C. pubescens leaves demonstrated cytotoxic and genotoxic effects through Allium strain bioassay, toxic effects were observed in the dividing cell and increased chromosomal alterations 20 . In vivo studies with Wistar and Drosophila melanogaster rats showed that the ethanolic extract obtained from fruits of C. pubescens under the experimental conditions used did not demonstrate significant genotoxic or clastogenic effects, indicating that fruit consumption is safe 54 .…”

Section: Toxicologymentioning

confidence: 94%

“…Regarding Campomanesia, this scenario is no different. Although these species are widely used as food and medicine in folk medicine, studies on the toxicology of many species are still scarce 54 .…”

Section: Toxicologymentioning

confidence: 99%

Campomanesia genus – a literature review of nonvolatile secondary metabolites, phytochemistry, popular use, biological activities, and toxicology

et al. 2020

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The genus Campomanesia belongs to the Myrtaceae family and has about 30 species. It is characterized by citrus-flavored fruits. Several articles describe the extensive use of its fruit, such as in the food industry, however, other parts of the plants are also used for food or pharmacological purposes such as the leaves, flowers, seeds, and roots. Analyzing works published on the genus in the period 2005-2019, we observed that the classes of main flavonoid compounds present are anthocyanins, chalcones, coumarins, tannins, and saponins. Species of this genus are also used as a medicine in the treatment of wounds, toothaches, fractures, and bruises. Therapeutic activities have also been detected for Campomanesia, such as antimicrobial, antiulcerogenic, antiprotozoal, anti-inflammatory, and antidiarrheal activity, antiproliferative and antioxidant potential, antiplatelet, antithrombotic, and fibrinolytic activities, as well as hypotensive effects. There are a small number of works demonstrating the low toxic potential of plant extracts. Thus, the Campomanesia genus presents pharmacological potential to be explored.

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“…The multiplicity of Cerrado plant species is superior to that found in other regions of the world, with shrub, liana and herbaceous plants, and the registered number reaches 12,669 species, of which, some stand out for their relevant pharmacological and nutritional properties, which play an important role in the commercial activities of regions where they are found. In addition, fruits of these plants also contribute to the promotion and development of family farming, generating income for communities through the preparation of sweets, ice cream, flavorings for alcoholic distillates and other by-products [ 7 , 8 , 9 ].…”

Section: Fruit Plants From the Brazilian Cerradomentioning

confidence: 99%

Ethnopharmacology of Fruit Plants: A Literature Review on the Toxicological, Phytochemical, Cultural Aspects, and a Mechanistic Approach to the Pharmacological Effects of Four Widely Used Species

et al. 2020

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Fruit plants have been widely used by the population as a source of food, income and in the treatment of various diseases due to their nutritional and pharmacological properties. The aim of this study was to review information from the most current research about the phytochemical composition, biological and toxicological properties of four fruit species widely used by the world population in order to support the safe medicinal use of these species and encourage further studies on their therapeutic properties. The reviewed species are: Talisia esculenta, Brosimum gaudichaudii, Genipa americana, and Bromelia antiacantha. The review presents the botanical description of these species, their geographical distribution, forms of use in popular medicine, phytochemical studies and molecules isolated from different plant organs. The description of the pharmacological mechanism of action of secondary metabolites isolated from these species was detailed and toxicity studies related to them were reviewed. The present study demonstrates the significant concentration of phenolic compounds in these species and their anti-inflammatory, anti-tumor, photosensitizing properties, among others. Such species provide important molecules with pharmacological activity that serve as raw materials for the development of new drugs, making further studies necessary to elucidate mechanisms of action not yet understood and prove the safety for use in humans.

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Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats

Cited by 19 publications

References 34 publications

Evaluation of the scientific activity of the leaf of the species Campomanesia pubescens in wound model infected by Staphylococcus aureus

Evaluation of the scientific activity of the leaf of the species Campomanesia pubescens in wound model infected by Staphylococcus aureus

Campomanesia genus – a literature review of nonvolatile secondary metabolites, phytochemistry, popular use, biological activities, and toxicology

Ethnopharmacology of Fruit Plants: A Literature Review on the Toxicological, Phytochemical, Cultural Aspects, and a Mechanistic Approach to the Pharmacological Effects of Four Widely Used Species

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