Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent

Bourrinet, Philippe; Bengele, H. H.; Bonnemain, Bruno; Dencausse, Anne; Idée, Jean‐Marc; Jacobs, Paula; Lewis, J.

doi:10.1097/01.rli.0000197669.80475.dd

Cited by 285 publications

(233 citation statements)

References 21 publications

(17 reference statements)

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…Headache or back pain, vasodilation, hypotension, or allergic reaction in the form of urticaria can occur on rare occasions [62]. No systemic toxic effects have been observed in animal experiments at concentrations up to 100 mg Fe/kg [63]. The amount of a chronic iron overload (> 20 g) is not reached even when used multiple times.…”

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

122

101

View full text Add to dashboard Cite

Superparamagnetic iron oxide nanoparticles (SPIO) can be used to image physiological processes and anatomical, cellular and molecular changes in diseases. The clinical applications range from the imaging of tumors and metastases in the liver, spleen and bone marrow, the imaging of lymph nodes and the CNS, MRA and perfusion imaging to atherosclerotic plaque and thrombosis imaging. New experimental approaches in molecular imaging describe undirected SPIO trapping (passive targeting) in inflammation, tumors and associated macrophages as well as the directed accumulation of SPIO ligands (active targeting) in tumor endothelia and tumor cells, areas of apoptosis, infarction, inflammation and degeneration in cardiovascular and neurological diseases, in atherosclerotic plaques or thrombi. The labeling of stem or immune cells allows the visualization of cell therapies or transplant rejections. The coupling of SPIO to ligands, radio- and/or chemotherapeutics, embedding in carrier systems or activatable smart sensor probes and their externally controlled focusing (physical targeting) enable molecular tumor therapies or the imaging of metabolic and enzymatic processes. Monodisperse SPIO with defined physicochemical and pharmacodynamic properties may improve SPIO-based MRI in the future and as targeted probes in diagnostic magnetic resonance (DMR) using chip-based ?NMR may significantly expand the spectrum of in vitro analysis methods for biomarker, pathogens and tumor cells. Magnetic particle imaging (MPI) as a new imaging modality offers new applications for SPIO in cardiovascular, oncological, cellular and molecular diagnostics and therapy. Key Points: Citation Format:

show abstract

Section: Distribution Degradation and Toxicitymentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Ittrich¹,

Peldschus²,

Raabe³

et al. 2013

Fortschr Röntgenstr

122

101

View full text Add to dashboard Cite

show abstract

“…133 In addition, another report shows the elimination of ∼20% of the injected dextran-coated SPIONs (with different size in comparison with ref 133) through urine and feces, in different animal models. 134 As predetermined, these differences in elimination of the NPs could be explained by variation of their protein corona compositions. Because of the physiological iron metabolism of cells, the surface degradation of SPIONs would be processed after their entrance to the intercellular medium, resulting in a temporary increase in iron amounts in the serum.…”

Section: In Vivo Toxicity Of Spionsmentioning

confidence: 99%

Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles

et al. 2011

View full text Add to dashboard Cite

“…This indicates that USPIO incorporation leads to a more severe inflammatory response, but there were no signs of iron oxide-related toxicity and it is very unlikely that the scaffolds contain amounts beyond their safety level (2.6 mg Fe/kg). 31 Our assumption is this thicker capsule is due to more severe apparent inflammatory response by the introduction of iron particles 32 and the hypointensity because of iron particles residuals. Higher resolution and/or functional MRI could obtain more detailed information of the capsule.…”

Section: Fig 5 T 2 -Weighted Magnetic Resonance Imaging (Mri) Ofmentioning

confidence: 99%

In VivoMagnetic Resonance Imaging of Type I Collagen Scaffold in Rat: Improving Visualization of Bladder and Subcutaneous Implants

Sun

Geutjes²,

Oosterwijk³

et al. 2014

Tissue Engineering Part C: Methods

View full text Add to dashboard Cite

Noninvasive monitoring of implanted scaffolds is important to understand their behavior and role in tissue engineering, in particular to follow their degradation and interaction with host tissue. Magnetic resonance imaging (MRI) is well suited for this goal, but its application is often hampered by the low contrast of scaffolds that are prepared from biomaterials such as type I collagen. The aim of this study was to test iron oxide particles incorporation in improving their MRI contrasts, and to follow their degradation and tissue interactions. Scaffolds with and without iron oxide particles were implanted either subcutaneously or on the bladder of rats. At predetermined time points, in vivo MRI were obtained and tissues were then harvested for histology analysis and transmission electron microscopy. The result showed that the incorporation of iron oxide particles improved MRI contrast of the implants, providing information on their location, shapes, and degradation. Second, the host tissue reaction to the type I collagen implants could be observed in both MRI and histology. Finally, MRI also revealed that the degradation and host tissue reaction of iron particles-loaded scaffolds differed between subcutaneous and bladder implantation, which was substantiated by histology.

show abstract

Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent

Abstract: The preclinical pharmacokinetic and safety profile of ferumoxtran-10 appears to be satisfactory in view of its proposed use as a single-dose diagnostic agent in human for MR imaging of lymph nodes.

Cited by 285 publications

References 21 publications

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Superparamagnetic Iron Oxide Nanoparticles in Biomedicine: Applications and Developments in Diagnostics and Therapy

Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles

In VivoMagnetic Resonance Imaging of Type I Collagen Scaffold in Rat: Improving Visualization of Bladder and Subcutaneous Implants

Contact Info

Product

Resources

About