Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles

Mahmoudi, Morteza; Hofmann, Heinrich; Rothen‐Rutishauser, Barbara; Petri‐Fink, Alke

doi:10.1021/cr2002596

Cited by 524 publications

(356 citation statements)

References 139 publications

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“…Cobalt and nickel are considerably toxic to the living environment, whereas iron oxide nanoparticles are mostly regarded biofriendly (36). Coating the robot surface would also drastically reduce the availability of the microswimmer bulk for cargo loading in and release from the porous hydrogel network.…”

Section: Design Fabrication and Mobility Of Microswimmersmentioning

confidence: 99%

“…risks raised by the use of nanoparticles should be taken into account in the line of the current literature (36). We anticipate that the degradation time could be further extended by introducing non-degradable methacryloyl polymers, such as poly(ethylene glycol) in the microswimmer network, so that the density of the enzyme-recognition sites would be lowered.…”

Section: Biodegradability With Mmp-2mentioning

confidence: 99%

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3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Ceylan

Yasa

Yaşa

et al. 2018

Preprint

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Miniaturization of interventional medical devices can leverage minimally invasive technologiesby enabling operational resolution at cellular length scales with high precision and repeatability.Untethered micron-scale mobile robots can realize this by navigating and performing in hard-toreach, confined and delicate inner body sites. However, such a complex task requires an integrated design and engineering strategy, where powering, control, environmental sensing, medical functionality and biodegradability need to be considered altogether. The present study reports a hydrogel-based, biodegradable microrobotic swimmer, which is responsive to the changes in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical magnetic microswimmer of 20 µm length, which is 3D-printed with complex geometrical and compositional features. At normal physiological concentrations, matrix metalloproteinase-2 (MMP-2) enzyme can entirely degrade the microswimmer body in 118 h to solubilized non-toxic products. The microswimmer can respond to the pathological concentrations of MMP-2 by swelling and thereby accelerating the release kinetics of the drug payload. Anti-ErbB 2 antibodytagged magnetic nanoparticles released from the degraded microswimmers serve for targeted labeling of SKBR3 breast cancer cells to realize the potential of medical imaging of local tissue sites following the therapeutic intervention. These results represent a leap forward toward clinical medical microrobots that are capable of sensing, responding to the local pathological information, and performing specific therapeutic and diagnostic tasks as orderly executed operations using their smart composite material architectures.

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Section: Design Fabrication and Mobility Of Microswimmersmentioning

confidence: 99%

Section: Biodegradability With Mmp-2mentioning

confidence: 99%

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Ceylan

Yasa

Yaşa

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…The first application of SPIO in cardiovascular regenerative medicine therapies was to label exogenous stem cells in order track these cells after injection into the infarct region in rodent models of MI (Kraitchman et al, 2003). While several studies show that IONPs do not affect cell viability, phenotype or therapeutic potential (Au et al, 2009;Li et al, 2013), other studies have raised concerns on their safety (Mahmoudi et al, 2011(Mahmoudi et al, , 2012Ge et al, 2013). Furthermore, their ability to track transplanted cells by MRI is controversial as the uptake of IONP by resident macrophages in the advent of transplanted cell apoptosis results in false-positive signals of cell engraftment in the infarct (Amsalem et al, 2007).…”

Section: (Vlp Vaccine Formentioning

confidence: 99%

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

et al. 2016

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Nanomaterials have attracted the interest of tissue engineers for the last two decades. Their unique properties make them promising for de novo fabrication of bio-inspired hybrid/composite materials with improved regenerative properties, including, for example, the capacity for electric conductivity and the provision of antimicrobial properties. However, to this day, the use of such materials in medical applications is rather limited and most of the studies have only reached the archetypical proof-of-concept stage. Herein, we present a review on the use of nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and nervous system. The advantages and limitations of nano-engineering materials are presented in this review alongside with the future challenges and milestones nanotechnology must overcome to make an impact in biomedical applications.

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“…Iron oxide NPs can reach the brain via the olfactory nerve resulted in OTS and ultra-structural alterations in the cells of the olfactory bulb (64). Although, there is little information about the health consequences of accumulation and retention of IONPs in the brain (59,65), including the striatum and hippocampus (25,66) it appears that iron-dependent processes are especially important for oligodendrocytes because of their highest content of iron compared to the other types of brain cells (67).…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Neurological Disorders and Oxidative Toxic Stress: A Role of Metal Nanoparticles

Mazdeh

Rahiminejad

Nili‐Ahmadabadi

et al. 2016

Jundishapur J Nat Pharm Prod

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Context: Oxidative stress is a hallmark of many types of neuropathology disorders and underlying mechanism in several neurodegenerative diseases and brain injuries. The CNS is particularly susceptible to oxidative toxic stress (OTS). Reactive oxygen spices are the basic inflammation and neurotoxicity mediators in ischemia/reperfusion injuries. The purpose of the present review is to provide an overview of some nanoparticles (NPs) in developing OTS conditions and neurological disorders. Evidence Acquisition: Here, a nanotechnology approach is evaluated using NPs in human neuronal protection against OTS. It may be wide therapeutic applications in the case of acute and/or chronic neurodegenerative disorders related to OTS. Results: In the brain of mice treated with nanosize TiO 2 , a significant association was found between the ability to induce the production of ROS and metabolic stress in intracellular environments and inflammatory responses in mice brai. The large surface area of AgNPs may efficiently facilitate the radicals generation including ROS in various organs. The production of ROS may cause DNA damage, cellular apoptosis, and activation of the mitogen activated protein kinase (MAPK) pathways which is responsible for regulating many cellular processes. Prolonged and excessive OTS may contribute to the activation of transcription factors and genes responsible for inflammation responses such as NF-κB and AP-1. Furthermore, OTS may contribute to the onset of neurodegenerative diseases. The ability of CuONPs to generate OTS in vitro studies has been demonstrated; however, information on the neurotoxicity of the CuONPs in vivo is low. Conclusions:The NPs-induced OTS may increase the pro-inflammatory responses. On the other hand, administration of antioxidants such as NAC and vitamin C and E prior to exposure to metal NPs significantly decreases OTS conditions.

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Assessing the In Vitro and In Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles

Cited by 524 publications

References 139 publications

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Nano-Engineered Biomaterials for Tissue Regeneration: What Has Been Achieved So Far?

Neurological Disorders and Oxidative Toxic Stress: A Role of Metal Nanoparticles

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