Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach

Pérez-Ortega, Gimena; Ángeles-López, Guadalupe Esther; Argueta-Villamar, Arturo; González-Trujano, María Eva

doi:10.1016/j.biopha.2017.06.064

Cited by 26 publications

(14 citation statements)

References 33 publications

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“…The composition of the plant oils can vary based on the genetic constitution of the species and the agronomic conditions in which the plants grow [24,25], as well as the studied part of the plant. As an example, T. erecta is another Tagetes species commonly used in Mexican traditional medicine, in addition to T. lucida [6,26]. Its major constituents reported in the leaf oil were piperitone (52.4%), terpinolene (11.2%), limonene (7.6%), (Z)-myroxide (4.2%), and piperitenone (5.0%), in comparison to the flower oil that contained piperitone (28.5%), piperitenone (10.9%), (Z)-myroxide (7.9%), piperitenone oxide (7.2%), β-caryophyllene (7.0%), limonene (6.9%), and terpinolene (4.7%) as the major constituents [24].…”

Section: Discussionmentioning

confidence: 99%

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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Tagetes lucida Cav. (Asteraceae) is an ancient medicinal plant commonly used to alleviate pain. Nevertheless, scientific studies validating this property are lacking in the literature. Animal models of pain were used to evaluate the antinociceptive and anti-inflammatory activities of T. lucida essential oil (TLEO) and a bioactive metabolite. The chemical constitution and possible toxicity of the extract and the mechanism of action of β-caryophyllene were also explored. Temporal course curves and dose–response graphics were generated using TLEO (0.1–10 mg/kg or 3.16–31.62 mg/kg) and β-caryophyllene (3.16–10 mg/kg). Metamizole (80 mg/kg) and indomethacin (20 mg/kg) were used as reference drugs in the formalin assay and writhing test in rats and mice, respectively. The β-caryophyllene mechanism of action was explored in the presence of naloxone (1 mg/kg), flumazenil (10 mg/kg), WAY100635 (0.16 mg/kg), or nitro-l-arginine methyl ester (L-NAME) (20 mg/kg) in the formalin test in rats. GC/MS analysis demonstrated the presence of geranyl acetate (49.89%), geraniol (7.92%), and β-caryophyllene (6.27%). Significant and dose-dependent antinociceptive response was produced by TLEO and β-caryophyllene without the presence of gastric damage. In conclusion, β-caryophyllene was confirmed as a bioactive compound in the T. lucida analgesic properties by involving the participation of receptors like opioids, benzodiazepines, and Serotonin 1A receptor (5-HT1A), as well as nitric oxide.

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Section: Discussionmentioning

confidence: 99%

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

et al. 2020

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“…The anxiolytic‐like actions of d ‐pinitol were evaluated on four behavioral models in mice. The LDB, EPM, cylinder exploratory test, and the OFT are commonly used to evaluate the anxiolytic or anxiogenic effects of drugs (Choleris et al, ; Hascoët & Bourin, ; Lister, ; Pérez‐Ortega et al, ). The LDB is based on the natural dislike of rodents to brightly areas and the exploration of new spaces (Hascoët & Bourin, ), whereas the cylinder exploratory test and the OFT evaluates, each, excitability of the central nervous system, and the aversion of mice to new and open environments (Choleris et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Each mouse was positioned in an opened acrylic cylinder. The frequency of rearing, when animals positioned over its back legs and touched the cylinder wall with both forelimbs, were recorded for 5 min (Pérez‐Ortega, Angeles‐López, Argueta‐Villamar, & González‐Trujano, ). In supplementary assays, groups of mice were intraperitoneally pre‐treated with 100 mg/kg 4‐chloro‐DL‐phenylalanine methyl ester hydrochloride (PCPA) (an inhibitor of serotonin synthesis), or 10 mg/kg pindolol (a 5‐HT1A/1B receptor antagonist).…”

Section: Methodsmentioning

confidence: 99%

Neuropharmacological effects of d ‐pinitol and its possible mechanisms of action

et al. 2019

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The aim was to evaluate the diuretic and neuropharmacological actions of d‐pinitol and describe a possible mechanism of action. The diuretic effects of d‐pinitol were evaluated using mice placed in metabolic cages. The sedative, anxiolytic‐like, antidepressant‐like, and anticonvulsant effects of 1–100 mg/kg d‐pinitol were assessed. The possible mechanisms of action of the anxiolytic‐like, antidepressant‐like, and anticonvulsant effects of d‐pinitol were evaluated using inhibitors. d‐pinitol lacked diuretic effects. However, d‐pinitol showed the highest anxiolytic‐like actions (ED50 = 70 mg/kg p.o. in mice) in the cylinder exploratory test and the highest antidepressant‐like activity in the forced swimming test (ED50 = 26 mg/kg p.o. in mice). d‐pinitol (100 mg/kg) exerted anticonvulsant actions in the pentylenetetrazole‐induced seizures test. The pre‐treatment with 2 mg/kg flumazenil reverted the anxiolytic‐like actions and the anticonvulsant effects of d‐pinitol, whereas the pre‐treatment with 1 mg/kg yohimbine and 0.05 mg/kg prazosin abolished the antidepressant effects of d‐pinitol. Practical applications d‐pinitol (3‐O‐methyl‐d‐chiro‐inositol) is a polyol found in many fruits, as well as in many members of the Leguminosae and Fabaceae families. The results propose that this compound could contribute in the treatment of anxiety, depression, and convulsions. The findings suggest the possible participation of the GABAergic system in the anxiolytic‐like and anticonvulsant actions of d‐pinitol, whereas the noradrenergic system is probably involved in the antidepressant effects of d‐pinitol. This study provides new information about other pharmacological uses for d‐pinitol.

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“…T. lucida , together with T. erecta and T. tenuifolia , is an important plant for treating folk illnesses considered cold or “friadad” such as “frío en el estómago” (cold in the stomach), “calor en el estómago” (heat in the stomach), and “empacho” (indigestion), as well as constipation, baby and child diarrhea, and eye irritation [ 127 ]. The remedies prepared with aerial parts of these plants are ointments employed in topical administration, in seat baths and in specific sweat lodges, in addition to flower infusions and tinctures consumed orally [ 127 , 128 ]. The use of T. erecta was documented in phytomedicine from Guatemala to cure the respiratory system against pneumonia, asthma, and tuberculosis, to cope with colic, for use as an antibiotic, analgesic, and antileukemic, and for wound healing, and immune system stimulating, as well as against headache, tetanus, and various parasites [ 129 ].…”

Section: Traditional Medicine Uses Of Tagetes Gmentioning

confidence: 99%

“…The efficacy of T. erecta on parasitic infections, as well as in the puerperium, is increased by combining all its aerial parts with those from other aromatic species in a Mexican syrup. Only the petals, however, are collected for the preparation of remedies useful in the affections of the central nervous system [ 128 ]. The infusion of T. erecta flowers covers a wide range of other actions against flu, fever, body pain, rash, sore throat, heart attack, and arthritis [ 130 ].…”

Section: Traditional Medicine Uses Of Tagetes Gmentioning

confidence: 99%

Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity

Salehi

Valussi²,

Morais-Braga

et al. 2018

Molecules

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Tagetes (marigold) is native to America, and its cultivation currently extends to other countries in Africa, Asia, and Europe. Many species of this genus, such as T. minuta, T. erecta, T. patula, and T. tenuifolia, are cultivated as ornamental plants and studied for their medicinal properties on the basis of their use in folk medicine. Different parts of the Tagetes species are used as remedies to treat various health problems, including dental, stomach, intestinal, emotional, and nervous disorders, as well as muscular pain, across the world. Furthermore, these plants are studied in the field of agriculture for their fungicidal, bactericidal, and insecticidal activities. The phytochemical composition of the extracts of different Tagetes species parts are reported in this work. These compounds exhibit antioxidant, antiinflammatory, and enzyme inhibitory properties. Cultivation and the factors affecting the chemical composition of Tagetes species are also covered. In the current work, available literature on Tagetes species in traditional medicine, their application as a food preservative, and their antimicrobial activities are reviewed.

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Preclinical evidence of the anxiolytic and sedative-like activities of Tagetes erecta L. reinforces its ethnobotanical approach

Cited by 26 publications

References 33 publications

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

Neuropharmacological effects of d ‐pinitol and its possible mechanisms of action

Tagetes spp. Essential Oils and Other Extracts: Chemical Characterization and Biological Activity

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