Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review

Hu, Shuangyuan; Zhao, Maoyaun; Li, Wei; Wei, Pengfei; Liu, Qingsong; chen, Shuanglan; Zeng, Jinhao; Ma, Xiao; Tang, Jian-Yuan

doi:10.1007/s10787-022-01079-8

Cited by 18 publications

(14 citation statements)

References 59 publications

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“…Loss of goblet cells as observed in CCG has been linked with oxidative stress mediators such as MDA that have apoptotic potential ( Elhassan, 2022 ). CHME and CH n HE prevented the loss of goblet cells perhaps due to the presence of quercetin which being a flavonoid opposes the oxidative stress markers such as MDA and this finding is in accordance with a previous work ( Hu et al, 2022 ). Colon wall thickening as exhibited in CCG is due to the infiltration of polymorphonuclear cells in the colon wall ( Qian et al, 2020 ).…”

Section: Discussionsupporting

confidence: 93%

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Rehman,

Saleem,

Raza

et al. 2024

Front. Chem.

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Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for this disease is available.Objective: The objective of the current study was to assess the effect of Calliandra haematocephala on inflammatory mediators and oxidative stress markers for the exploration of its anti-ulcerative colitis activity in rat models of acetic acid-induced ulcerative colitis.Methods: Methanolic and n-hexane extracts of areal parts of the plant were prepared by cold extraction method. Phytochemical analysis of both extracts was performed by qualitative analysis, quantitative methods, and high-performance liquid chromatography (HPLC). Prednisone at 2 mg/kg dose and plant extracts at 250, 500, and 750 mg/kg doses were given to Wistar rats for 11 days, which were given acetic acid on 8th day through the trans-rectal route for the induction of ulcerative colitis. A comparison of treatment groups was done with a normal control group and a colitis control group. To evaluate the anti-ulcerative colitis activity of Calliandra haematocephala, different parameters such as colon macroscopic damage, ulcer index, oxidative stress markers, histopathological examination, and mRNA expression of pro and anti-inflammatory mediators were evaluated. mRNA expression analysis was carried out by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR).Results: The phytochemical evaluation revealed polyphenols, flavonoids, tannins, alkaloids, and sterols in both extracts of the plant. Results of the present study exhibited that both extracts attenuated the large bowel inflammation and prevented colon ulceration at all tested doses. Macroscopic damage and ulcer scoreswere significantly decreased by both extracts. Malondialdehyde (MDA) levels and nitrite/nitrate concentrations in colon tissues were returned to normal levels while superoxide dismutase (SOD) activity was significantly improved by all doses. Histopathological examination exhibited that both extracts prevented the inflammatory changes, cellular infiltration, and colon thickening. Gene expression analysis by RT-qPCR revealed the downregulation of pro-inflammatory markers such as tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) whereas the anti-inflammatory cytokines including Interleukin-4 (IL-4) and Interleukin-10 (IL-10) were found to be upregulated in treated rats.Conclusion: It was concluded based on study outcomes that methanolic and n-hexane extracts of Calliandra haematocephala exhibited anti-ulcerative colitis activity through modulation of antioxidant defense mechanisms and the immune system. In this context, C. haematocephala can be considered as a potential therapeutic approach for cure of ulcerative colitis after bioassay-directed isolation of bioactive phytochemicals and clinical evaluation.

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Section: Discussionsupporting

confidence: 93%

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Rehman,

Saleem,

Raza

et al. 2024

Front. Chem.

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“…Quercetin has been shown to have excellent modulation potential on bacteria in many types of diseases, including neurodegenerative disease, metabolic disease, and IBD [ 89 , 90 , 91 , 92 ]. As an important constituent of CHM-derived polyphenols, quercetin prevents the onset of IBD by inhibiting oxidative stress and inflammation, in which gut bacteria are indispensable players.…”

Section: Polyphenols Retard Oxidative Stress and Inflammation Via Mod...mentioning

confidence: 99%

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Peng

Ding

et al. 2023

Antioxidants

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Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated with oxidative stress, unbalanced gut microbiota, and aberrant immune response. Indeed, oxidative stress can affect the progression and development of IBD by regulating the homeostasis of the gut microbiota and immune response. Therefore, redox-targeted therapy is a promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, are able to maintain redox equilibrium in the intestinal tract to prevent abnormal gut microbiota and radical inflammatory responses. Here, we provide a comprehensive perspective for implementing natural antioxidants as potential IBD candidate medications. In addition, we demonstrate novel technologies and stratagems for promoting the antioxidative properties of CHM-derived polyphenols, including novel delivery systems, chemical modifications, and combination strategies.

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“…Traditional Chinese medicine has gradually gained attention due to its fewer side effects and more targets (Ding et al, 2022). Quercetin belongs to avonoids and has various effects such as antiin ammatory and antioxidant stress (Hu et al, 2022;Tang et al, 2019). It has a protective effect on neurodegenerative diseases and can signi cantly improve learning, memory, and cognitive impairmen (Paula et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

Gong,

Xu,

et al. 2024

Preprint

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Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. At present, the main treatment strategy is to alleviate certain symptoms, but the potential mechanisms of AD are not fully understood, and there is a lack of effective treatment methods in clinical practice. Quercetin (QT) can significantly protect neurodegeneration by inhibiting oxidative stress and inflammation, and has the potential to play a greater role in clinical practice. Therefore, this study aims to explore the potential mechanism of QT based on the AMPK/mTOR pathway in improving the learning and memory abilities of AD rats.For this purpose,we established an AD rat model by injecting Hcy into the tail vein.After successful model validation, Quercetin and AMPK inhibitor were gavaged.Then, the role of the AMPK/mTOR pathway in QT protected nerve regeneration was determined using Morris water maze, Nissl staining, Western blot and immunohistochemistry.We observed that QT significantly improved the learning and memory abilities in rat models with AD, as demonstrated by the short learning latency and greater times of travel across the platform. Nissl staining showed that QT could reduce neurological Apoptosis and amenorrate neurological implementation .Western blot and immunohistochemistry staining showed that questionnaire significantly increased p-AMPK, while reducing p-mTOR and p-Tau .In addition, the application of specific AMPK inhibitor can effectively reverse these changes, further enhancing the improvement effect of QT inhibition on AD, Thereby improving the learning and memory improvement induced by Hcy in AD model rates, and thus improving learning and memory abilities.

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Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review

Cited by 18 publications

References 59 publications

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Anti-ulcerative colitis effects of chemically characterized extracts from Calliandra haematocephala in acetic acid-induced ulcerative colitis

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease?

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR

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