Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice

Chassot, Janaíne Micheli; Longhini, Renata; Gazarini, Lucas; Mello, João Carlos Palazzo de; Oliveira, Rúbia Maria Weffort de

doi:10.1016/j.jep.2011.07.032

Cited by 32 publications

(18 citation statements)

References 27 publications

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“…However, the protective mechanism of EAF on pancreatic islets remains to be further clarified. We hypothesized that EAF has potentially beneficial effects against pancreatic β-cell apoptosis that may derive from its anti-inflammatory capacity and inhibitory actions against free radicals [13].…”

Section: Discussionmentioning

confidence: 99%

“…The crude extract was dissolved in water, and EAF was isolated using an ethyl-acetate solution as previously described [13,16].…”

Section: Plant Materials and Extract Preparationmentioning

confidence: 99%

“…Previously, our group reported the antioxidant capacity of EAF from the bark of T. catigua, where nine polyphenolic constituents with antioxidant effects were found [11,13]. Furthermore, subchronic treatment with EAF promoted an antidepressant effect as well as increased hippocampal cell proliferation in mice [12].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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Background/Aims: Trichilia catigua A. Juss., known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, our group demonstrated that the ethyl-acetate fraction (EAF) of T. catigua has antioxidant and anti-inflammatory effects. The present study evaluated the anti-diabetic activity of EAF in type 1 diabetic rats. Methods: Male Wistar rats were divided into four groups (N: non-diabetic group, D: type 1 diabetic group, NC: non-diabetic + EAF group and DC: type 1 diabetic + EAF group). The latter two groups were treated with 200 mg/kg EAF. Type 1 diabetes was induced by intravenous streptozotocin (STZ) injection (35 mg/kg). Starting two days after STZ injection, EAF was administered daily by gavage for 8 weeks. Results: EAF attenuated body mass loss and reduced food and water intake. EAF improved hyperglycaemia and other biochemical parameters, such as alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Furthermore, the number of pancreatic β-cells and the size of the islets had increased by β-cell proliferation in the DC group. EAF promoted reduction in kidney tissue damage in STZinduced diabetic rats by reduction of renal fibrosis. Conclusion: The present study showed that EAF improves glucose homeostasis and endocrine pancreas morphology and inhibits the development of diabetic nephropathy in STZ-induced diabetic rats.

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Section: Discussionmentioning

confidence: 99%

“…The crude extract was dissolved in water, and EAF was isolated using an ethyl-acetate solution as previously described [13,16].…”

Section: Plant Materials and Extract Preparationmentioning

confidence: 99%

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Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Gomes

Paulo

Panizzon

et al. 2017

Cell Physiol Biochem

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“…The preparation was then filtered, concentrated in a rotavapor (Büchi R-153, Switzerland) under reduced pressure, and lyophilized to yield the CAT (2942 g, 19.35%) (Chassot et al, 2011). The preparation was then filtered, concentrated in a rotavapor (Büchi R-153, Switzerland) under reduced pressure, and lyophilized to yield the CAT (2942 g, 19.35%) (Chassot et al, 2011).…”

Section: Plant Materials and Extract Preparationmentioning

confidence: 99%

The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring

Santos

Ramos

Silveira

et al. 2015

Journal of Ethnopharmacology

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“…It is used in Brazilian popular medicine as a tonic for the treatment of fatigue, stress, impotence, and memory deficits, mainly due to its ability to inhibit or protect against free radicals. The crude extracts and isolated compounds (epicatechin, cinchonains Ia, Ib, IIa, IIb, catiguanins A and B, apocynin E, and procyanidins B2 and C1) from the bark of T. catigua show antioxidant activity toward the free radical 2,2-diphenyl-2-picrylhydrazyl (DPPH), and reduction of the Fe 3+ / ferricyanide complex to the ferrous form [9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of multiple emulsions for controlled release ofTrichilia catigua(Catuaba) extract

Lonni

Munhoz

Lopes

et al. 2015

Pharmaceutical Development and Technology

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Considering the antioxidant activity of the Trichilia catigua extract (TCE), the aim of the current study was to develop and characterize W/O/W multiple emulsions containing different vegetable oils as a platform to deliver a TCE. The extract displayed antioxidant activity (IC) of 4.59 µg/mL and total phenol content (TPC) of 50.84%. Formulations were prepared by the phase-inversion emulsification method and analyzed for morphological appearance, pH, conductivity, droplet size and distribution, content of active, rheological properties, in vitro release, skin permeation, and stability. Formulations prepared with canola oil were selected and displayed regular morphology, mean diameter 2.77 µm (without TCE), 3.07 µm with 0.5% and 3.23 µm with 1.0% TCE. Rheometry (flow) showed pseudoplastic behavior with minimal thixotropy for both systems. TCE could be released from emulsions containing 1.0% and 0.5% TCE in a controlled manner for 16 and 23 h, respectively. The emulsions allowed good retention of TCE in the skin (stratum corneum, epidermis, and dermis). In a 180-d assessment of accelerated chemical stability, TPC was more reduced for the emulsions at 40 °C; other parameters remained stable. Multiple emulsions containing TCE were developed, exhibited good characteristics, and may be considered for future investigations as anti-aging formulations for the skin.

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Preclinical evaluation of Trichilia catigua extracts on the central nervous system of mice

Abstract: The present results showed an in vitro antioxidant activity for EAF and suggested that it may be useful for cognitive improvement. It is possible that both functional and chemical activities are related.

Cited by 32 publications

References 27 publications

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

Anti-Diabetic Effects of the Ethyl-Acetate Fraction of Trichilia catigua in Streptozo-tocin-Induced Type 1 Diabetic Rats

The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring

Development and characterization of multiple emulsions for controlled release ofTrichilia catigua(Catuaba) extract

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