Preclinical Chemosensitivity Studies with Human Soft Tissue Sarcomas in Nude Mice

Budach, V.; Bamberg, M.; Scheulen, M. E.; Niederle, N.; Krause, U.

doi:10.1159/000429538

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1993

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“…No complete remission was noted, but we obtained a specific growth delay of 1.5 (expressed as +, according to the European multicenter recommendations (Boven et al, 1988)). This SGD was comparable for these drugs to that obtained by Budach et al (1986) in 8/16 soft-tissue sarcoma xenografts.…”

Section: Disc'ussionsupporting

confidence: 71%

Characterization and chemosensitivity of a human epithelioid sarcoma cell line (SARCCR 2)

Roché

Julia

Jozan

et al. 1993

Intl Journal of Cancer

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A new cell line was derived from the epithelioid sarcoma of a Caucasian woman who had previously received chemotherapy. The cells grew as an adherent monolayer, with a doubling time of 28 hr and had mainly epithelial morphology, but with areas of mesenchymal-like cytoplasmic extensions. The cells were tumorigenic in nude mice, with a short growth time, and a doubling time of 8 days. The cell line showed over-expression of P-glycoprotein by Western blot analysis, and its sensitivity to doxorubicin and vincristine was low. This sensitivity could be enhanced by reversants of multidrug resistance (MDR), such as cyclosporin or verapamil. This cell line constitutes an excellent model for studying compounds able to reverse MDR.

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Section: Disc'ussionsupporting

confidence: 71%