Precision targeting with a tracking adaptive optics scanning laser ophthalmoscope

Hammer, Daniel X.; Ferguson, R. Daniel; Bigelow, Chad E.; Iftimia, Nicusor; Ustun, Teoman E.; Noojin, Gary D.; Stolarski, David J.; Hodnett, Harvey M.; Imholte, Michelle L.; Kumru, Semih S.; McCall, Michelle; Toth, Cynthia A.; Rockwell, Benjamin A.

doi:10.1117/12.647477

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…One potential area is in the selective targeting of retinal pigment epithelial cells for the treatment of age-related macular degeneration [13]. We have begun to investigate adaptive optics in combination with other technologies for that application [7]. Future studies will explore many avenues of inquiry related to understanding the fundamental mechanisms of vision and the diagnosis and treatment of diseases which affect vision.…”

Section: Discussionmentioning

confidence: 99%

“…The adaptive optics component uses a Hartmann-Shack wave-front sensor and deformable mirror to detect and correct ocular aberrations in a closed loop. The system also includes a port that can be used for delivery of near-diffraction-limited stimulus or therapeutic beams to the retina [7]. Those beams require an external independent focus and are collimated into the port behind the deformable mirror.…”

Section: Taoslo System Description 21 Overviewmentioning

confidence: 99%

“…The significant finding of this work is the characterization of hierarchical elements of the AO stabilization problem. The system has the potential to be used in a wide variety of applications beyond disease diagnosis, from precision stimulus presentation for vision studies to therapeutic laser targeting of malignant retinal structures [7]. This paper describes the design and features of the TAOSLO system and the results of preliminary tests on normal human subjects.…”

Section: Introductionmentioning

confidence: 99%

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Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging

Hammer¹,

Ferguson²,

Bigelow³

et al. 2006

Opt. Express

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118

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A retinal imaging instrument that integrates adaptive optics (AO), scanning laser ophthalmoscopy (SLO), and retinal tracking components was built and tested. The system uses a Hartmann-Shack wave-front sensor (HS-WS) and MEMS-based deformable mirror (DM) for AO-correction of high-resolution, confocal SLO images. The system includes a wide-field line-scanning laser ophthalmoscope for easy orientation of the high-magnification SLO raster. The AO system corrected ocular aberrations to <0.1 μm RMS wave-front error. An active retinal tracking with custom processing board sensed and corrected eye motion with a bandwidth exceeding 1 kHz. We demonstrate tracking accuracy down to 6 μm RMS for some subjects (typically performance: 10-15 μm RMS). The system has the potential to become an important tool to clinicians and researchers for vision studies and the early detection and treatment of retinal diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Taoslo System Description 21 Overviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging

Hammer¹,

Ferguson²,

Bigelow³

et al. 2006

Opt. Express

Self Cite

118

View full text Add to dashboard Cite

show abstract

“…Roorda, et al, 2002), eye tracking (D. X. Hammer, et al, 2005), hemodynamic (R. Daniel Ferguson, Daniel X. Hammer, 2004), tomography (Fernando Romero-Borja, et al, 2005), etc.…”

Section: Introductionmentioning

confidence: 99%

“…In 2005, Indiana University developed Tracking AOCSLO (D. X. Hammer, et al, 2005), and David Merino combined AOCSLO and AOOCT (D. Merino, Chris Dainty, 2006) to improve both lateral resolution and axial resolution.…”

Section: Introductionmentioning

confidence: 99%