Precision photothermal therapy and photoacoustic imaging by <i>in situ</i> activatable thermoplasmonics

Qing, Guangyan; Mo, Fengye; Hu, Jiaying; Jiang, Qunying; Wang, Xiuyuan; Zou, Zhiqiao; Zhang, Xian‐Zheng; Pang, Dai‐Wen; Liu, Xiaoqing

doi:10.1039/d1sc02203b

Cited by 26 publications

(15 citation statements)

References 57 publications

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“…The accumulation of high concentrations of photothermal substances at the tumor site can increase photothermal effects and decrease side effects. 32 In this study, the NS implant delivered a high drug concentration around the injection site in vitro, ex vivo, and in vivo. The ICG-NS implant enables effective photothermal treatment by delivering a high concentration of photothermal material to the desired area, particularly the tumor.…”

Section: Resultsmentioning

confidence: 96%

Development of Injectable and Biodegradable Needle-Type Starch Implant for Effective Intratumoral Drug Delivery and Distribution

Lee¹

2022

IJN

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Introduction Compared to intravenous administration, intratumoral drug administration enables the direct delivery of drugs to tumors and mitigates the systemic absorption of drugs and associated drug-induced side effects. However, intratumoral drug administration presents several challenges. The high interstitial fluid pressure (IFP) of the tumor prevents the retention of drugs within the tumor; thus, significant amounts of the drugs are absorbed systemically through the bloodstream or delivered to non-target sites. To solve this problem, in this study, a drug-enclosed needle-type starch implant was developed that can overcome IFP and remain in the tumor. Methods Injectable needle-type starch implants (NS implants) were prepared by starch gelatinization and drying. The structure, cytotoxicity, and anticancer effects of the NS implants were evaluated. Biodistribution of NS implants was evaluated in pork (in vitro), dissected liver (ex vivo), and 4T1 tumors in mice (in vivo) using a fluorescence imaging device. Results The prepared NS implants exhibited a hydrogel structure after water absorption. NS implants showed effective cytotoxicity and anticancer effects by photothermal therapy (PTT). The NS implant itself has sufficient strength and can be easily injected into a desired area. In vivo, the NS implant continuously delivered drugs to the tumor more effectively and uniformly than conventional hydrogels and solutions. Conclusion This study demonstrated the advantages of needle-type implants. An injectable NS implant can be a new formulation that can effectively deliver drugs and exhibit anticancer effects.

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Section: Resultsmentioning

confidence: 96%

Development of Injectable and Biodegradable Needle-Type Starch Implant for Effective Intratumoral Drug Delivery and Distribution

Lee¹

2022

IJN

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“…In addition to accurately detecting FEN1, subDNA@AuNS can further realize tumor-targeted drug delivery and controllable drug release. AuNS is not only a carrier for building an activatable FEN1 imaging probe that can protect DNA from enzymatic degradation and improve cell uptake efficiency , but also an excellent photothermal agent because of plasmonic heating. , Therefore, we investigated the photothermal transduction efficiency of a DNA nanosphere under NIR laser irradiation (Figure S12). The photothermal effect of subDNA@AuNS firmly relies on the power density of laser and the concentration of nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

“…Theranostics has attracted intense attention because it allows disease diagnostics in combination with therapeutics. − However, the nonspecific response of the theranostic agents in healthy tissues remains a big challenge for their practical applications, which results in unreliable analyses of diagnosis and even induces severe adverse effects of treatment because of off-target toxicity . Very recently, engineering precision nanoparticles have arisen as an innovative approach to achieving targeted and precision nanomedicine. − Well-designed nanoparticles may respond to a biomarker and trigger on-demand drug release for accurate diagnosis and therapy of disease as precision theranostics . As such, we sought to design activatable nanoparticles that can specifically sense a cancer biomarker and spatiotemporally modulate drug release for finer-controlled theranostics.…”

Section: Introductionmentioning

confidence: 99%

Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy

Jiang

Qing

et al. 2021

Anal. Chem.

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Accurate diagnosis and targeted therapy are essential to precision theranostics. However, nonspecific response of theranostic agents in healthy tissues impedes their practical applications. Here, we design an activatable DNA nanosphere for specifically in situ sensing of cancer biomarker flap endonuclease 1 (FEN1) and spatiotemporally modulating drug release. The gold nanostar-conjugated FEN1 substrate acts as spherical nucleic acid and induces a fluorescence signal upon a FEN1 stimulus for diagnosis. Guided by the nanoflare, external NIR light then triggers a controlled release of carried drugs at desired sites. This DNA nanosphere not only exhibits good stability, sensitivity, and specificity toward FEN1 assay but also serves as a precision theranostic agent for targeted and controlled drug delivery. Our study provides a reliable method for FEN1 imaging in vitro and in vivo and suggests a powerful strategy for precision medicine.

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“…The ingenious design of fluorescence sensing nanoplatforms shows immense importance for imaging intracellular biomarkers. − As the vital small molecule, adenosine triphosphate (ATP) plays an indispensable role in regulating many biochemical syntheses and metabolic processes in living entities. − A disordered ATP level is often associated with many biological processes or diseases such as Parkinson’s disease, hypoglycemia, hypoxia, ischemia, and angiocardiopathy. − Therefore, it is of essential significance to develop reliable and specific methods that can recognize and image ATP for biochemical research and clinical diagnosis.…”

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confidence: 99%

A Cooperatively Activatable DNA Nanoprobe for Cancer Cell-Selective Imaging of ATP

Zhou

Zou

et al. 2021

Anal. Chem.

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DNA-based nanoprobes have attracted extensive interest in the field of bioanalysis. Notably, engineered DNA nanoprobes that can respond to multiple pathological parameters are desirable to detect targets precisely. Here we design a split aptamer/DNAzyme (aptazyme)-based DNA probe for fluorescence detection of ATP and further develop a cooperatively activatable DNA nanoprobe for tumor-specific imaging of ATP in vivo. The DNA nanoprobes comprising split aptazyme-coated MnO 2 nanovectors have high stability and are synergistically activated by multiple biomarkers, GSH and ATP. Upon stimuli by overexpressed GSH in tumor cells, this DNA nanoprobe can release the aptazyme and self-supply cofactor Mn 2+ of the DNAzyme. Sequentially, intracellular ATP induces the proper folding of the split ATP aptamer and Mn 2+ -dependent DNAzyme, which activates the specific cleavage of substrate and generates the optical readout signal. This nanoprobe exhibits remarkable resistance to enzymatic degradation, satisfactory biosafety, identifies ATP specifically within cancer cells, and selectively lights up solid tumors. Our research provides a reliable method for ATP imaging in cancer cells and opens a new avenue for biochemical research and highly accurate disease diagnosis.

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Precision photothermal therapy and photoacoustic imaging by in situ activatable thermoplasmonics

Abstract: Phototherapy holds great promise for disease treatment; however, traditional “always-on” photoagents have been restricted for clinical translation due to nonspecific response and side effects on normal tissues. Here, we show...

Cited by 26 publications

References 57 publications

Development of Injectable and Biodegradable Needle-Type Starch Implant for Effective Intratumoral Drug Delivery and Distribution

Development of Injectable and Biodegradable Needle-Type Starch Implant for Effective Intratumoral Drug Delivery and Distribution

Precision Spherical Nucleic Acids Enable Sensitive FEN1 Imaging and Controllable Drug Delivery for Cancer-Specific Therapy

A Cooperatively Activatable DNA Nanoprobe for Cancer Cell-Selective Imaging of ATP

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