Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients

D’Auria, Enza; Mameli, Chiara; Piras, Cristian; Cococcioni, Lucia; Urbani, Andrea; Zuccotti, Gian Vincenzo; Roncada, Paola

doi:10.1016/j.jprot.2018.01.018

Cited by 48 publications

(39 citation statements)

References 109 publications

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“…The majority of patients with IgE CMA are sensitized to more than one CM allergen, with a great variability in the specificity and intensity of the IgE responses. Molecular-based allergy diagnosis allows to associate each patient with a specific immunoreactive profile and to identify different CMA phenotypes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

et al. 2018

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The role and prevalence of cow’s milk protein allergy (CMA) in functional gastrointestinal disorders remains unclear. The aim of this review is to update knowledge on the relationship between CMA and functional abdominal pain disorders (FAPDs) in children. Cochrane Database and Pubmed were searched from inception using general and specific terms for CMA and functional gastrointestinal disorders. CMA is reported as a predisposing or coexisting factor in a wide range of functional gastrointestinal disorders in infants and children. Pathogenesis of both conditions is complex and multiple mechanisms including dysmotility and hypersensitivity might contribute to the clinical manifestations. Data supporting the possible role of food allergies in the pathogenesis of FAPDs are limited. CMA may predispose to early life inflammation and visceral hypersensitivity, which in turn might manifest as FAPDs. The diagnosis of either CMA or FAPDs and distinction between them is challenging because of nonspecific and overlapping symptoms. Lack of accurate allergy tests in non-IgE (immunoglobulin E) mediated cases is also problematic. Oral food challenge, following an elimination diet, should be performed to diagnose a suspected non-IgE CMA allergy in children with FAPDs. In the management of FAPDs, an elimination diet should be considered for a limited period to verify if the symptoms improve or resolve.

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Section: Introductionmentioning

confidence: 99%

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

et al. 2018

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“…In the last decade, allergen-component resolved diagnostics (CRD) has become increasingly used in the diagnostic work-up, aiding the clinicians to optimize decisions about if, when and how to perform OFC (25). In clinical practice, component resolved diagnostics (CRD) may be useful for evaluation of reactivity to baked milk, helping to identify different clinical phenotypes on the basis of molecular patient specific IgE profile.…”

Section: Type Of Allergen and The "Matrix Effect": The Lesson From MImentioning

confidence: 99%

Personalized Nutrition in Food Allergy: Tips for Clinical Practice

2020

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Nowadays, food allergies are considered as a wide spectrum of disorders that need different approaches. The "one size fits all" approach is giving way to a "targeted approach," based on the identification of the patient's phenotype. Thus, the approach of nutritional management of food allergy has moved on from simply being "yes or no" to "how much?", "in which form?" and "for which patients?" Different factors should be considered in order to make a patient-tailored nutritional plan in clinical practice. Tailored nutritional plans may help to reduce the nutritional, social and economic burden of food allergy.

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“…In case of milk allergy, the IgE-associated symptoms (relating to skin, respiratory system, and gastrointestinal tract) can be seen immediately or in sometime (about 2 h) after milk intake. Sometimes, complex and systematic anaphylactic response can be observed due to involvement of one or more target organs [21,22]. Different standard gold diagnosis methods for CMA are available such as the double-blind, placebo-controlled oral food challenge (DBPCFC) and unblinded oral food challenge (OFC) [23].…”

Section: Number Of Amino Acids/moleculesmentioning

confidence: 99%

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

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et al. 2019

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Among prevalent food allergies, cow milk allergy (CMA) is most common and may persist throughout the life. The allergic individuals are exposed to a constant threat due to milk proteins’ presence in uncounted food products like yogurt, cheese, and bakery items. The problem can be more severe due to cross-reactivity of the milk allergens in the food products due to homologous milk proteins of diverse species. This problem can be overcome by proper and reliable food labeling in order to ensure the life quality of allergic persons. Therefore, highly sensitive and accurate analytical techniques should be developed to detect the food allergens. Here, significant research advances in biosensors (specifically immunosensors and aptasensors) are reviewed for detection of the milk allergens. Different allergic proteins of cow milk are described here along with the analytical standard methods for their detection. Additionally, the commercial status of biosensors is also discussed in comparison to conventional techniques like enzyme-linked immunosorbent assay (ELISA). The development of novel biosensing mechanisms/kits for milk allergens detection is imperative from the perspective of enforcement of labeling regulations and directives keeping in view the sensitive individuals.

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Precision medicine in cow's milk allergy: proteomics perspectives from allergens to patients

Cited by 48 publications

References 109 publications

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Cow’s Milk Protein Allergy in Infancy: A Risk Factor for Functional Gastrointestinal Disorders in Children?

Personalized Nutrition in Food Allergy: Tips for Clinical Practice

Nano-Biosensing Platforms for Detection of Cow’s Milk Allergens: An Overview

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