Precise ratiometric loading of PTX and DOX based on redox-sensitive mixed micelles for cancer therapy

Zhao, Dujuan; Wu, Jilian; Li, Chuanxiang; Zhang, Huiyuan; Li, Zhonghao; Luan, Yuxia

doi:10.1016/j.colsurfb.2017.03.056

Cited by 56 publications

(33 citation statements)

References 42 publications

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“…In order to achieve a desirable therapeutic effect, a high drug dosage and repeated administration are required, which will cause drug loss, multi‐drug resistance, and side effects to patients . Various DOX‐carrier systems including micelles, liposomes, polymer drug conjugates, dendrimers, and micro‐ and nanoparticles have been developed to improve the antitumor therapeutic efficacy. However, their accumulation and the targeted drug delivery ability remain lacking.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Poly(lactic‐co‐glycolic acid)‐Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows

Zhao

Zheng

et al. 2018

Macromolecular Bioscience

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In this work, a novel kind of electrospun microfiber to deliver a photothermal agent and an anticancer drug to tumor sites is explored. Photothermal therapy agent (MoS nanosheets) and doxorubicin (DOX) are incorporated with poly(lactic-co-glycolic acid) (PLGA) microfiber via electrospinning a solution of PLGA, MoS , and DOX. The designed microfiber with uniform fibrous morphology and negligible in vitro/in vivo hemo-/histo-toxicity is used as a durable photothermal agent, which shows an excellent photothermal transform ability and acceptable photothermal stability in both the first and second near-infrared light (NIR I and II) biowindows. The synergistic in vivo tumor chemotherapy and photothermal therapy efficiency of the composite microfibers are studied in postoperative treatment of cancer. It is found that the tumor postoperative reoccurrence can be completely prohibited owing to the synergistic tumor therapy efficiency in both the NIR I and NIR II biowindows.

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Section: Introductionmentioning

confidence: 99%

Preparation of Poly(lactic‐co‐glycolic acid)‐Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows

Zhao

Zheng

et al. 2018

Macromolecular Bioscience

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“…A study reported improved delivery of conventional chemotherapeutics by using QDs that had very low toxicity as nanocarrier [ 97 ]. Likewise, a mixed micelle system based on mPEG-SS-PTX and mPEG-SS-DOX conjugate has a significant cytotoxicity to A549 cells [ 98 ]. In another study, HA-modified SeNPs loaded with PTX (HA-Se@PTX) displayed significant cellular uptake and controlled release of PTX in vitro [ 100 ].…”

Section: Application and Clinical Trials Of Nanocarrier-based Thermentioning

confidence: 99%

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Wei

Lau

2020

Cancers

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Conventional chemotherapy is still an important option of cancer treatment, but it has poor cell selectivity, severe side effects, and drug resistance. Utilizing nanoparticles (NPs) to improve the therapeutic effect of chemotherapeutic drugs has been highlighted in recent years. Nanotechnology dramatically changed the face of oncology by high loading capacity, less toxicity, targeted delivery of drugs, increased uptake to target sites, and optimized pharmacokinetic patterns of traditional drugs. At present, research is being envisaged in the field of novel nano-pharmaceutical design, such as liposome, polymer NPs, bio-NPs, and inorganic NPs, so as to make chemotherapy effective and long-lasting. Till now, a number of studies have been conducted using a wide range of nanocarriers for the treatment of solid tumors including lung, breast, pancreas, brain, and liver. To provide a reference for the further application of chemodrug-loaded nanoformulations, this review gives an overview of the recent development of nanocarriers, and the updated status of their use in the treatment of several solid tumors.

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“…As known, DOX is a kind of anthraquinone drug which inhibits tumour growth and induces apoptosis by embedding DNA base segments in cancer cells. This embedding can block the transcription and replication of DNA . When taking higher doses, the systemic toxicity, especially the cardio toxicity, will result in a deadly side effect.…”

Section: Introductionmentioning

confidence: 99%

Acid‐sensitive reactive oxygen species triggered dual‐drug delivery systems for chemo‐photodynamic therapy to overcome multidrug resistance

Yin

Bao

Liu

et al. 2020

Polymer International

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In clinical treatment, multidrug resistance (MDR) is one of the major obstacles resulting in the failure of chemotherapy. It is still a challenge to overcome MDR. Herein, we fabricated intelligent dextran-based dual-drug delivery systems histidine modified dextran conjugated doxorubicin/zinc porphyrin/paclitaxel (DHTD/Zn-TPP/PTX) via supramolecular metallo-coordination for synergistic chemo-photodynamic therapy to overcome cancer drug resistance. In this designed DHTD/Zn-TPP/PTX, one anticancer drug (doxorubicin, DOX) was conjugated on the dextran backbone through a reactive oxygen species sensitive linker and the other drug PTX was encapsulated into the acid responsive supramolecular micelles formed by the photosensitizer Zn-TPP and histidine grafted on dextran. DHTD/Zn-TPP/PTX with excellent stability could be effectively internalized by tumour cells. In the acidic tumour environment, the loaded PTX and Zn-TPP as photosensitizer could be released; moreover, when irradiated with light the conjugated DOX could be specifically released because the linker broke. As the obtained data indicate, DHTD/Zn-TPP/PTX exhibited not only an enhanced anticancer therapeutic effect but also significant growth inhibition for drug-resistant MCF-7/ADR cells to reverse MDR, having great potential for synergistic treatments of cancer to overcome MDR.

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Precise ratiometric loading of PTX and DOX based on redox-sensitive mixed micelles for cancer therapy

Cited by 56 publications

References 42 publications

Preparation of Poly(lactic‐co‐glycolic acid)‐Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows

Preparation of Poly(lactic‐co‐glycolic acid)‐Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Acid‐sensitive reactive oxygen species triggered dual‐drug delivery systems for chemo‐photodynamic therapy to overcome multidrug resistance

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