Preparation of Poly(lactic‐co‐glycolic acid)‐Based Composite Microfibers for Postoperative Treatment of Tumor in NIR I and NIR II Biowindows

Abstract

In this work, a novel kind of electrospun microfiber to deliver a photothermal agent and an anticancer drug to tumor sites is explored. Photothermal therapy agent (MoS nanosheets) and doxorubicin (DOX) are incorporated with poly(lactic-co-glycolic acid) (PLGA) microfiber via electrospinning a solution of PLGA, MoS , and DOX. The designed microfiber with uniform fibrous morphology and negligible in vitro/in vivo hemo-/histo-toxicity is used as a durable photothermal agent, which shows an excellent photothermal transform ability and acceptable photothermal stability in both the first and second near-infrared light (NIR I and II) biowindows. The synergistic in vivo tumor chemotherapy and photothermal therapy efficiency of the composite microfibers are studied in postoperative treatment of cancer. It is found that the tumor postoperative reoccurrence can be completely prohibited owing to the synergistic tumor therapy efficiency in both the NIR I and NIR II biowindows.

<p>Antibacterial properties of in situ and surface functionalized impregnation of silver sulfadiazine in polyacrylonitrile nanofiber mats</p>

“…30 Electrospinning is a useful technique to fabricate nanofibers having diameters ranging from tens of nanometer to microns. 31,32 Electrospinning was introduced in 1931 and hence is not a new method for fabrication of nanofibers, but a proper setup for producing nanofibers by this method became practical and popular in the early 21st century. From then onward, it has been used for the production of nanofibers for different applications, including water filtration, wound care, breathe masks, and other biomedical applications.…”

<p>Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment</p>

“…CP, CP/MoS 2 , and CP/MoS 2 /DOX nanofibers were fabricated via electrospinning under ambient conditions. Based on a previous study,27 the concentration of MoS 2 nanosheets and DOX in the electrospinning solution was selected as 6 mg/mL and 10 mg/mL, respectively. The applied voltage was 20 kV, the collecting distance was 20 cm, and the solution feeding rate was 0.3 mL/h by homemade syringe pump.…”

“…Bearing the aforementioned issues of chemotherapeutics and PTAs in mind, researchers have proposed various kinds of intelligent platforms including injectable hydrogel, oleosol, and polymeric implants for safely localized tumor treatments 9,27. Electrospun polymer nanofibers, owing to their unique properties including high surface-to-volume ratio, tunable porosity, and ease of surface functionalization, have attracted high attention in a number of fields, such as filtration, textile manufacturing, catalysts, and pharmaceutics 28–30.…”

“…As a therapeutic carrier, nanofiber can improve the drug-loading capacity and effectively control drug release. Moreover, the nanofibrous matrix may exert a discernible impact on the safety of guest materials while not compromising their function 27,31,32…”

“…In a previous study, MoS 2 nanosheets and DOX-loaded poly(lactic-co-glycolic) acid (PLGA) nanofibers have been successfully prepared via directly electrospinning the mixture solution of PLGA, MoS 2 , and DOX, for the efficient postoperative treatment of tumor in NIR I and NIR II biowindows 27. However, due to the strong hydrophobicity of PLGA, PLGA/MoS 2 /DOX nanofibers severely shrank after being implanted into the tumor site.…”