Precise evaluation of the block copolymer nanoparticle growth in polymerization-induced self-assembly under dispersion conditions

Su, Yang; Xiao, Xue; Li, Shentong; Dan, Meihan; Wang, Xiaohui; Zhang, Wangqing

doi:10.1039/c3py00995e

Cited by 58 publications

(102 citation statements)

References 65 publications

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“…10 Since the insolubility of the blocks increases with the block length extension during the course of polymerization, the amphiphilic diblock copolymers self-assemble into a set of polymer nano-objects. [11][12][13][14][15][16][17] A wide range of well-defined morphologies were produced by the PISA, including spheres, worms, vesicles, concentric vesicles, large-compound vesicles and so on. [18][19][20] Although the PISA has its inherent advantages in terms of versatility and efficiency, it is still a young field for researches and the fundamental understanding of the PISA remains incomplete in several aspects.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] Although the PISA has its inherent advantages in terms of versatility and efficiency, it is still a young field for researches and the fundamental understanding of the PISA remains incomplete in several aspects. 9,16,17,[21][22][23][24][25][26][27] For example, the essential difference between the PISA and traditional self-assembly is unclear; the physical mechanism (equilibrium or non-equilibrium behavior) underlying the balance between the polymerization and self-assembly needs to be explored; and the phase diagrams in the PISA should be mapped out to reproduce the PISA process. Insight into these problems can promote nano-object development from trial-and-error towards knowledge-driven innovation.…”

Section: Introductionmentioning

confidence: 99%

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An insight into polymerization-induced self-assembly by dissipative particle dynamics simulation

Huang

Wang

et al. 2016

Soft Matter

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Polymerization-induced self-assembly is a one-pot route to produce concentrated dispersions of block copolymer nano-objects. Herein, dissipative particle dynamics simulations with a reaction model were employed to investigate the behaviors of polymerization-induced self-assembly. The polymerization kinetics in the polymerization-induced self-assembly were analyzed by comparing with solution polymerization. It was found that the polymerization rate enhances in the initial stage and decreases in the later stage. In addition, the effects of polymerization rate, length of macromolecular initiators, and concentration on the aggregate morphologies and formation pathway were studied. The polymerization rate and the length of the macromolecular initiators are found to have a marked influence on the pathway of the aggregate formations and the final structures. Morphology diagrams were mapped correspondingly. A comparison between simulation results and experimental findings is also made and an agreement is shown. This work can enrich our knowledge about polymerization-induced self-assembly.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An insight into polymerization-induced self-assembly by dissipative particle dynamics simulation

Huang

Wang

et al. 2016

Soft Matter

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“…Through subsequent chain-extension with styrene, PDMA- b -PS with a trithiocarbonate end group was obtained (Figures 7a and S15). 53 The resulting diblock copolymer was treated with our optimized bromination protocol (Figure 7a). Analysis by SEC showed negligible change in the molar mass or Đ of the polymer during bromination (RI trace, Figure 7b) and confirmed the disappearance of the CTA chain-end (UV-vis trace, Figure 7c).…”

Section: Resultsmentioning

confidence: 99%

Desulfurization–bromination: direct chain-end modification of RAFT polymers

et al. 2017

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We report a simple and efficient transformation of thiol and thiocarbonylthio functional groups to bromides using stable and commercially available brominating reagents. This procedure allows for the quantitative conversion of a range of small molecule thiols (including primary, secondary and tertiary) to the corresponding bromides under mild conditions, as well as the facile chain-end modification of polystyrene (PS) homopolymers and block copolymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. Specifically, the direct chain-end bromination of PS prepared by RAFT was achieved, where the introduced terminal bromide remained active for subsequent modification or chain-extension using classical atom transfer radical polymerization (ATRP). This transformation sets the foundation for bridging RAFT and ATRP, two of the most widely used controlled radical polymerization (CRP) strategies, and enables the preparation of chain-end functionalized block copolymers not directly accessible using a single CRP technique.

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“…Although spherical particles are commonly produced by PISA systems, controlling the diameter of PISA micelles was not demonstrated in early work . In 2010, Armes and coworkers reported the use of RAFT dispersion polymerization for the production of sterically stabilized micelles with a range of controlled diameters .…”

Section: Raft Dispersion Polymerizationmentioning

confidence: 99%

Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization‐Induced Self‐Assembly

Khor

Quinn

Whittaker

et al. 2018

Macromol. Rapid Commun.

145

136

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Rapid developments in the polymerization-induced self-assembly (PISA) technique have paved the way for the environmentally friendly production of nanoparticles with tunable size and shape for a diverse range of applications. In this feature article, the biomedical applications of PISA nanoparticles and the substantial progress made in controlling their size and shape are highlighted. In addition to early investigations into drug delivery, applications such as medical imaging, tissue culture, and blood cryopreservation are also described. Various parameters for controlling the morphology of PISA nanoparticles are discussed, including the degree of polymerization of the macro-CTA and core-forming polymers, the concentration of macro-CTA and core-forming monomers, the solid content of the final products, the solution pH, the thermoresponsitivity of the macro-CTA, the macro-CTA end group, and the initiator concentration. Finally, several limitations and challenges for the PISA technique that have been recently addressed, along with those that will require further efforts into the future, will be highlighted.

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Precise evaluation of the block copolymer nanoparticle growth in polymerization-induced self-assembly under dispersion conditions

Cited by 58 publications

References 65 publications

An insight into polymerization-induced self-assembly by dissipative particle dynamics simulation

An insight into polymerization-induced self-assembly by dissipative particle dynamics simulation

Desulfurization–bromination: direct chain-end modification of RAFT polymers

Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization‐Induced Self‐Assembly

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