Precipitation and Characterization of Chelerythrine Microparticles by the Supercritical Antisolvent Process

Hong, Hailong; Suo, Quan‐Ling; Li, Fawang; Wei, Xionghui

doi:10.1002/ceat.200800114

Cited by 11 publications

(10 citation statements)

References 26 publications

(23 reference statements)

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“…In addition, the increase in pressure augments the diffusion of SCF into the solvent, ensuing supersaturation that subsequently results in small-sized particles. [68][69][70] However, the changes in the pressure had no significant influence on the biological activity of the sensitive molecules such as enzymes. 71…”

Section: Pressurementioning

confidence: 99%

“…In some instances, an increase in temperature results in severe aggregation of the particles with irregular surfaces due to collisions among the microparticles and vice versa. [68][69][70] To this end, the drug loading efficiency in the polymeric carriers is reduced during these conditions due to phase separation, which was articulated in a thermodynamics point of view.…”

Section: Temperaturementioning

confidence: 99%

“…The effective mechanisms that played a vital role during atomization were clearly explained by He et al 63 They explained that two different but complementary mechanisms are involved: 1) prompt atomization and 2) the wave mechanism during atomization. 63,70 The mechanism of prompt atomization is generally correlated to the speed of liquid sheet at the edge of the atomizer tip, which is maintained low at a lower flow rate, resulting in an intense equivalent momentum transfer between the solution and SC-CO 2 and eventually disintegrates the sheet into fine droplets. 63,70 The energy per unit mass of liquid in these conditions that gained from the dense gas to fragment the sheet into drops decreases with increase in the solution flow rate at a constant Vc (ie, flow rate of CO 2 at the standard state [temperature 273 K, pressure 101, 325 Pa] in L/min), which increases the droplet size and, subsequently, the particle size of the end product.…”

Section: Solution Flow Ratementioning

confidence: 99%

“…63,70 The mechanism of prompt atomization is generally correlated to the speed of liquid sheet at the edge of the atomizer tip, which is maintained low at a lower flow rate, resulting in an intense equivalent momentum transfer between the solution and SC-CO 2 and eventually disintegrates the sheet into fine droplets. 63,70 The energy per unit mass of liquid in these conditions that gained from the dense gas to fragment the sheet into drops decreases with increase in the solution flow rate at a constant Vc (ie, flow rate of CO 2 at the standard state [temperature 273 K, pressure 101, 325 Pa] in L/min), which increases the droplet size and, subsequently, the particle size of the end product. 63,70 Supercritical fluid SCF in these anti-solvent processes acts not only as an anti-solvent, but also as a spray enhancer and a reprecipitation aid.…”

Section: Solution Flow Ratementioning

confidence: 99%

See 3 more Smart Citations

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kankala¹,

Chen²,

Liu³

et al. 2018

IJN

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In recent years, the supercritical fluid (SCF) technology has attracted enormous interest from researchers over the traditional pharmaceutical manufacturing strategies due to the environmentally benign nature and economically promising character of SCFs. Among all the SCF-assisted processes for particle formation, the solution-enhanced dispersion by supercritical fluids (SEDS) process is perhaps one of the most efficient methods to fabricate the biomaterials and pharmaceutical compounds at an arbitrary gauge, ranging from micro- to nanoscale. The resultant miniature-sized particles from the SEDS process offer enhanced features concerning their physical attributes such as bioavailability enhancement due to their high surface area. First, we provide a brief description of SCFs and their behavior as an anti-solvent in SCF-assisted processing. Then, we aim to give a brief overview of the SEDS process as well as its modified prototypes, highlighting the pros and cons of the particular modification. We then emphasize the effects of various processing constraints such as temperature, pressure, SCF as well as organic solvents (if used) and their flow rates, and the concentration of drug/polymer, among others, on particle formation with respect to the particle size distribution, precipitation yield, and morphologic attributes. Next, we aim to systematically discuss the application of the SEDS technique in producing therapeutic nano-sized formulations by operating the drugs alone or in combination with the biodegradable polymers for the application focusing oral, pulmonary, and transdermal as well as implantable delivery with a set of examples. We finally summarize with perspectives.

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Section: Pressurementioning

confidence: 99%

Section: Temperaturementioning

confidence: 99%

Section: Solution Flow Ratementioning

confidence: 99%

Section: Solution Flow Ratementioning

confidence: 99%

See 2 more Smart Citations

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kankala¹,

Chen²,

Liu³

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Micronization processes with an SCF as antisolvent have been investigated in recent years [12][13][14][15][16][17][18][19][20][21][22][23][24]. In the gas antisolvent (GAS) process, a solute is dissolved in an organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Kinetic Modeling of the Gas Antisolvent Process for Synthesis of 5‐Fluorouracil Nanoparticles

Esfandiari¹,

Ghoreishi²

2013

Chem Eng & Technol

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Mathematical modeling for 5-fluorouracil (5-FU) nanoparticle synthesis via gas antisolvent (GAS) process was investigated. 5-FU was precipitated from a dimethyl sulfoxide (DMSO) solution using CO 2 as antisolvent. The particle size was controlled by nucleation and growth rates, therefore, the kinetic modeling study is essential. Thermodynamic modeling was applied to determine optimal operating conditions for experimental 5-FU synthesis. Kinetic parameters were evaluated by fitting the particle size distribution predicted by the model to experimental data. The experimental and modeling results indicated that the particle size decreased with increasing the antisolvent addition rate. IntroductionSince conventional methods of particle micronization, such as jet milling, suffer from various shortcomings [1, 2], alternative methods like particle micronization with supercritical fluid (SCF) became attractive for the pharmaceutical industry [3][4][5][6][7][8]. In most of these techniques, supercritical CO 2 was applied, as it is nontoxic, nonreactive, nonflammable, and inexpensive [9,10]. Particle size distribution could be controlled by changing the operating variables, such as temperature, antisolvent addition rate, and initial solute concentration [8,11].Micronization processes with an SCF as antisolvent have been investigated in recent years [12][13][14][15][16][17][18][19][20][21][22][23][24]. In the gas antisolvent (GAS) process, a solute is dissolved in an organic solvent. The solution is then expanded by CO 2 injection into a precipitator. Sharp reduction of solute solubility in the liquid phase is observed, and subsequently the particle is precipitated. Many experimental studies were performed to produce micro-and nanoparticles via the GAS process [2,3,7,10,12,13]. Phase equilibrium models are essential to evaluate the feasibility of this process. A new definition of volume expansion was proposed to determine the thermodynamic criteria [25]. Optimum conditions for ternary systems were investigated [26].Modelings of phenanthrene and belcomethasone-17,21-dipropionate precipitation via an antisolvent process were described [27][28][29][30].5-Fluorouracil (5-FU) is applied in the treatment of cancers [31]. Çiftçi et al. [32] investigated the creation of microspheres of 5-FU from polylactic acid by means of a solvent evaporation technique. Production of 5-FU nanoparticles with solutionenhanced dispersion by the supercritical method at pressures of 10 and 15 MPa at 40°C was studied [33].Optimal conditions for 5-FU precipitation via the GAS process were obtained by thermodynamic modeling. 5-FU nanoparticles were synthesized experimentally under various antisolvent flow rates. Kinetic modeling was investigated and validated by comparison of experimental and predictive data. Nucleation and growth rate parameters were attained by comparing experimental and modeling data. Thermodynamic ModelingAppropriate operations in the experiments of 5-FU precipitation were obtained via thermodynamic modeling. The Peng Robinson equat...

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Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

Kankala

Zhang

Wang

et al. 2017

Adv Healthcare Materials

222

184

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During the past few decades, supercritical fluid (SCF) has emerged as an effective alternative for many traditional pharmaceutical manufacturing processes. Operating active pharmaceutical ingredients (APIs) alone or in combination with various biodegradable polymeric carriers in high-pressure conditions provides enhanced features with respect to their physical properties such as bioavailability enhancement, is of relevance to the application of SCF in the pharmaceutical industry. Herein, recent advances in drug delivery systems manufactured using the SCF technology are reviewed. We provide a brief description of the history, principle, and various preparation methods involved in the SCF technology. Next, we aim to give a brief overview, which provides an emphasis and discussion of recent reports using supercritical carbon dioxide (SC-CO2) for fabrication of polymeric carriers, for applications in areas related to drug delivery, tissue engineering, bio-imaging, and other biomedical applications. We finally summarize with perspectives.

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Precipitation and Characterization of Chelerythrine Microparticles by the Supercritical Antisolvent Process

Cited by 11 publications

References 26 publications

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Solution-enhanced dispersion by supercritical fluids: an ecofriendly nanonization approach for processing biomaterials and pharmaceutical compounds

Kinetic Modeling of the Gas Antisolvent Process for Synthesis of 5‐Fluorouracil Nanoparticles

Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications

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