Prebiotic Effect of Inulin Extract from Dahlia Tubers (Dahlia Pinnata L.) On the Growth Performance of Intestinal-origin Lactobacillus Casei AP.

Widodo, Widodo; Kusmiyati, Nur; Wahyunings, Tutik Dwi

doi:10.3923/pjn.2018.405.410

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…Moreover, milk components hydroxy methyl glutarate, uronic acids and conjugated linoleic acid are also known to play a role in lowering cholesterol (Marinangeli and Peter, 2010). L. casei AP and AG produce short-chain fatty acids (Kusmiyati et al, 2018) that can reduce lipolysis in adipose tissue, thereby reducing concentrations of circulating free and/or nonesterified fatty acids. The reduction in circulating free fatty acids moderates triglyceride synthesis in the liver as well as very LDL secretion, thus controlling increases in plasma triglyceride concentrations.…”

Section: Effect Of Fermented Milk On Blood Cholesterol and Lipidsmentioning

confidence: 99%

Antidiabetic effect of milk fermented using intestinal probiotics

Widodo

Harsita

Sukarno

et al. 2019

NFS

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Purpose Diabetes is a chronic metabolic disease that accounted for 6 per cent of total Indonesian deaths in 2016. The purpose of this study is to evaluate the ability of milk fermented using intestinal origin Lactobacillus casei strains to alleviate hyperglycemia in rats. Design/methodology/approach L. casei strains AP and AG were previously isolated and identified from feces of breastfed Indonesian infants (<1 month-old) and confirmed to be probiotics in vitro. These strains were used as bacterial starters to ferment milk, and the fermented product was fed to 25 diabetic rats for 15 days; metformin was used as a positive control. Blood glucose concentration, lipid profiles and total lactic acid bacteria counts were analyzed before and after treatment. Findings The results showed that feeding rats with milk fermented using L. casei strain AP decreased blood glucose concentration from 172.4 ± 2.1 to 147.2 ± 6.0 mg/dL (p < 0.05), whereas metformin reduced blood glucose concentration from 173.5 ± 6.5 to 124.2 ± 16.9 mg/dL (p < 0.05). Feeding milk fermented either L. casei AP or AG decreased low density lipoprotein but increased high density lipoprotein levels (p < 0.05). Research limitations/implications This research finding is expected to increase the development of fermented dairy products as functional food, solutions for the prevention of hyperglycemia diseases which have a higher risk to occur on humans. Practical implications Further study is needed to examine the effect of L. casei AP-fermented milk on humans with hyperglycemia. Social implications This research finding is expected to increase the development of fermented dairy products as functional food. Originality/value Oral administration of L. casei AP-fermented milk reduced hyperglycemia in rats similar to metformin. Further study is needed to examine the effect of L. casei AP-fermented milk on humans with hyperglycemia.

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Section: Effect Of Fermented Milk On Blood Cholesterol and Lipidsmentioning

confidence: 99%

Antidiabetic effect of milk fermented using intestinal probiotics

Widodo

Harsita

Sukarno

et al. 2019

NFS

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“…Ogawa et al [20] found that LAB fermentation is effective in improving the level of CLA. L. casei AP is an LAB that can produce short-chain fatty acids (SCFA) [21]. In addition to CLA, SCFA lowers lipolysis in the adipose tissue, thereby reducing the levels of circulating free fatty acids and non-esterified fatty acids [22].…”

Section: Discussionmentioning

confidence: 99%

Milk Fermented with <em>Lactobacillus casei </em>Strain AP Improves Lipid Profiles in Obese Indonesian Adults

Widodo¹,

Denta²,

Sunarti³

et al. 2021

Preprint

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Obesity and hyperglycemia can trigger various diseases, including diabetes mellitus and cardiovascular ailments. Health-promoting fermented milk products can be useful in tackling these issues. One such product is the fermented milk developed using Lactobacillus casei AP, a probiotic strain from Indonesia that has not been tested in humans thus far. Our objective was to examine the effects of L. casei AP-fermented milk products on lipid profiles, blood glucose levels and monocyte chemoattractant protein-1 (MCP-1) levels in obese adults. A total of 29 obese subjects were given L. casei AP-fermented milk products, and their fasting blood glucose, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were measured using diagnostic system kits. MCP-1 levels were measured using enzyme-linked immunosorbent assay. It was determined that the administration of L. casei AP-fermented milk products significantly reduced total cholesterol, LDL and triglyceride levels (p < 0.05); however, it did not increase HDL (p > 0.05), MCP-1 or fasting blood glucose levels (p ≥ 0.05). In conclusion, in obese Indonesian adults, L. casei AP-fermented milk might reduce total cholesterol, LDL and triglyceride levels but may not affect HDL, MCP-1 or fasting blood glucose levels.

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“…The mechanism of action of inulin from dahlia tubers as a prebiotic can be seen in Figure 4. Studies have found that inulin extract from dahlia tubers is proven to optimally support the growth of the probiotic Bifidobacterium bifidum, increase lactose degradation, and accelerate lactic acid production [19] . This potential is also supported by other publications showing the role of dahlia tuber inulin in supporting the probiotic Lactobacillus casei successfully inhibiting the growth of the bacteria Helicobacter pylori and Shigella dysenteriae significantly [19] .…”

Section: Potential Of Inulin In Dahlia Tuber (Dahlia Pinnata) As a Pr...mentioning

confidence: 99%

“…Studies have found that inulin extract from dahlia tubers is proven to optimally support the growth of the probiotic Bifidobacterium bifidum, increase lactose degradation, and accelerate lactic acid production [19] . This potential is also supported by other publications showing the role of dahlia tuber inulin in supporting the probiotic Lactobacillus casei successfully inhibiting the growth of the bacteria Helicobacter pylori and Shigella dysenteriae significantly [19] . In addition, the synbiotic combination of dahlia tuber inulin and Lactobacillus plantarum is the best combination which can increase the amount up to 2.80 × 1010 CFU/ml, 1.29% total acid, and 2.05% total sugar [8] .…”

Section: Potential Of Inulin In Dahlia Tuber (Dahlia Pinnata) As a Pr...mentioning

confidence: 99%

Synbiotic Potential of Probiotics Lactobacillus plantarum and Inulin from Dahlia Tubers (Dahlia Pinnata) and Fortification of Nano-Fe as Stunting Management: Future Perspective in Indonesia

Meidira Putri Callista,

Rahmanto,

Qamar

et al. 2023

IJRP

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Stunting is still a recent child health problem, including in Indonesia. The study found that conditions of disturbed microflora balance in the digestive tract were correlated with the incidence of stunting in children. Provision of weaning food in the form of synbiotics as a combination of probiotics and prebiotics are suspected to be able to manage stunting by optimizing nutritional status, balancing the gut microbiota and digestive tract health. Inulin from Dahlia tuber (Dahlia pinnata) has the potential as a source of prebiotics which is safe for consumption and has no toxic effects. In addition, Lactobacillus plantarum isolate is a probiotic that can optimize the environment in the digestive tract. On the other hand, supplementing iron with nanoparticles helps meet the needs of the micronutrient iron and its absorption, which plays a role in the formation of hemoglobin in red blood cells, which is important for child growth. This literature review aims to explore the synbiotic potential of probiotic Lactobacillus plantarum and prebiotic inulin from Dahlia tubers with nano-Fe fortification as weaning food for stunting management in Indonesia.

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Prebiotic Effect of Inulin Extract from Dahlia Tubers (Dahlia Pinnata L.) On the Growth Performance of Intestinal-origin Lactobacillus Casei AP.

Cited by 6 publications

References 15 publications

Antidiabetic effect of milk fermented using intestinal probiotics

Antidiabetic effect of milk fermented using intestinal probiotics

Milk Fermented with <em>Lactobacillus casei </em>Strain AP Improves Lipid Profiles in Obese Indonesian Adults

Synbiotic Potential of Probiotics Lactobacillus plantarum and Inulin from Dahlia Tubers (Dahlia Pinnata) and Fortification of Nano-Fe as Stunting Management: Future Perspective in Indonesia

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