Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis

Petit, Morgane; Mine, Louis; Pascreau, Tiffany; Brouzes, Chantal; Majoux, Sandrine; Borgel, Delphine; Beaudeux, Jean-Louis; Lasne, Dominique; Hennequin, Carole

doi:10.1684/abc.2017.1287

Cited by 7 publications

(20 citation statements)

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“…We revealed that PTS led to a remarkable decrease in FVIII activity in nearly all the samples and the maximal bias reached 42.1%. Recently, a small sample size study reported that FVIII activity decreased in 33.3% (2/6) of samples transported by PTS, 12 which was similar to our findings. Since the classification of the severity of hemophilia A (HA) is based on FVIII activity: <1% as severe; 1%‐5% as moderate; and >5%‐<40% as mild, 17 false decrease of FVIII activity results may lead to misclassification, especially for cases with FVIII activities close to the boundary value.…”

Section: Discussionsupporting

confidence: 91%

“…So far, the impacts of PTS on complete blood cell count, biochemical tests, and blood gas analysis have been reported in previous studies 6‐9 . Yet, only a limited number of coagulation tests, such as prothrombin time (PT) and activated partial thromboplastin time (APTT), have been explored 10‐13 . The aim of this study was to systematically evaluate the impact of PTS on hemostasis tests including routine coagulation tests, coagulation factor activity tests, fibrinolytic parameters, and anticoagulation indicators.…”

Section: Introductionmentioning

confidence: 99%

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Falsely decreased FVIII activity following pneumatic tube transport

Wang

Liang

et al. 2020

Int J Lab Hematology

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Introduction The pneumatic tube system (PTS) is widely used for sample delivery. We aimed to investigate the impacts of PTS on hemostasis assays. Methods Triplicate samples from 30 healthy volunteers were delivered to the core laboratory manually by human courier or via the 500 m long‐distance PTS or via the 1000 m long‐distance PTS. Comparisons of 19 hemostasis tests were conducted. Results Although PT, INR, APTT, FII, FV, FVII FIX, FX, FXII, DD, α2‐PI, and PC had statistical significance (all P < .05), all had low average bias remaining within clinical acceptable limits. PTS transportation only resulted in a statistically significant and clinically relevant decrease in FVIII activity. In the 500 m‐PTS group, 66.7% (20/30) of samples for FVIII testing had a bias greater than 8.3%. Moreover, in the 1000 m‐PTS group, 96.7% (29/30) of samples had a bias of over 8.3%, and the maximal bias achieved 42.1%. Conclusions Pneumatic tube system in our institution could be used to deliver blood samples for hemostasis tests evaluated in this study except FVIII activity assay.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Falsely decreased FVIII activity following pneumatic tube transport

Wang

Liang

et al. 2020

Int J Lab Hematology

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“…The pneumatic tube system may lead to hemolysis,31 and potassium levels may differ in the central laboratory. 18,27,32 Also; the difference between the time elapsed between sampling and analysis can influence the BGA and AA electrolyte measurements, especially K. 24…”

Section: Discussionmentioning

confidence: 99%

Interchangeability of Sodium and Potassium Result Values of Arterial Blood Gas with Laboratory Analyzer: Narrative Review

Üstündağ

Huysal

Özgünay

et al. 2019

Indian Journal of Critical Care Medicine

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The major extracellular electrolytes, sodium, and potassium are often requested together and form a large percentage of the requested tests in routine clinical chemistry laboratories. Two types of devices that use direct and indirect ion-selective electrode (ISE) methods are used in hospitals for electrolyte measurements: blood gas analyzers (BGA), which use direct ISE technology, and the indirect ISE method, which is often used in a central-laboratory autoanalyzer (AA). We aimed to summarize the current scientific knowledge based on whether the electrolyte test results, using Na and K test results obtained with BGA and an AA, can be used interchangeably. We searched Medline (PubMed), Google Scholar, and Web of Science up to 31st March 2018. In addition, references of the included studies were also examined. Fourteen studies with a risk of bias were included in the analysis. Limits of agreement differences were variable among BGA and AA sodium and potassium test results in clinical practice. The results of both BGA and AA measures should not be used interchangeably under the assumption that they are equivalent to each other. How to cite this article Ustundağ Y, Huysal K, Ozgunay ŞE, Turkoğlu AR. Interchangeability of Sodium and Potassium Result Values of Arterial Blood Gas with Laboratory Analyzer: Narrative Review. Indian Journal of Critical Care Medicine, January 2019;23(1):35-42.

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“…However, parameters such as LDH and AST (p-value = 0.000) concluded that statistically signi cant differences were observed from samples transferred via PTS compared to hand-delivered samples when tested for these. Moreover, Petit et al (2017) studied the preanalytic in uence of PTS in biochemistry analytes -Potassium, LDH, and AST. The samples are from 14 individuals.…”

Section: Blood Chemistrymentioning

confidence: 99%

A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

Ausmolo

Pua

Abiog

et al. 2022

Preprint

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Introduction: Today, many hospitals use a Pneumatic Tube System (PTS) to quickly convey specimens to the lab. This study examined the clinical and practical impacts of PTS in delivering specimens. Blood chemistry and hematologic parameters were compared between PTS and manual transfer to determine whether there was a significant increase or decrease in its values. The study evaluated the following Blood Chemistry parameters such as LDH, K, AST, ALP, ALT, and Total Bilirubin and Hematologic parameters such as Red Cell indices (MCV, MHC, and MCHC), RBC count, Hemoglobin and Hematocrit, Hemolysis rate, and Platelet count. The data are gathered to evaluate if PTS provides the same specimen integrity as the manual technique. In this project, the researchers will conduct a systematic review utilizing the PRISMA 2020 reporting checklist. Methodology: Studies obtained from online databases were utilized. A set of criteria for selecting prospective studies were established. The studies should be published from 2017 to October 2022, must assess the effects of PTS by comparing them to manually transported samples, and must be fully accessible. Subgroup analysis and cumulative analysis were conducted to establish transparency of the results. Findings and Discussion: A total of 27 studies were evaluated. Among these, 13 of the studies included are for blood chemistry and 15 studies are for hematology. Among all the parameters evaluated, only LDH, potassium, and Hemolysis index showed clinical significance between the samples transported via PTS and manually delivered. The other chemistry parameters were also increased but were not clinically significant. Whereas, Hematologic parameters have only limited studies available that can show that it is of clinical significance. However, most included studies utilized a small sample size and limited population, restricting further analysis of obtained results. Additionally, some were hindered due to insufficient data and information. Moreover, the technical aspects that can cause the results to differ are not provided because the PTS utilized to modify acceleration and deceleration, are not sufficiently described. Some research claimed that their study was restricted to PTS effects alone.

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Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis

Cited by 7 publications

References 0 publications

Falsely decreased FVIII activity following pneumatic tube transport

Falsely decreased FVIII activity following pneumatic tube transport

Interchangeability of Sodium and Potassium Result Values of Arterial Blood Gas with Laboratory Analyzer: Narrative Review

A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

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