Falsely decreased FVIII activity following pneumatic tube transport

Wang, Hong; Wang, Lin; Liang, Hanyu; Wei, Jia; Wu, Yidi; Xu, Jian

doi:10.1111/ijlh.13363

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…However, our results showed that for the delivery of FFP or cryoprecipitate, there was no significant difference in the value of routine haematology and coagulation parameters, including PT, PT‐INR, APTT, TT and FIB, between the specimens tested before and after RLTS transport. In addition, several labile coagulation factors, such as FVIII and FV, have half‐lives that are sensitive to PTS transportation conditions [23]. In contrast, our results showed no significant impact of RLTS transport on FVIII activity results.…”

Section: Discussioncontrasting

confidence: 60%

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Evaluation of a rail logistics transmission system for the transportation of blood components within a medical centre

Chen,

Zang,

Wang

et al. 2023

Vox Sanguinis

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Background and ObjectivesRail logistics transmission systems (RLTSs) are commonly used for the transportation of blood samples, pathological specimens and other medical materials in many hospitals, as they are rapid, secure, cost‐effective and intelligent. However, few studies have evaluated blood component transportation from blood banks to the patient care areas of hospitals using RLTS. In this study, we evaluate the RLTS used for the transportation of blood components within a medical centre.Materials and MethodsThe dispatch of blood components, including packed red blood cells (pRBCs), fresh frozen plasma (FFP), cryoprecipitate and platelet units, from a blood bank to critical care areas or general wards was done using RLTS. Parameters such as the delivery time, temperature, physical integrity and blood component quality were evaluated via analytical testing using specimens obtained before and after transportation by RLTS.ResultsThe turnaround time and temperature of all tested blood units via RLTS transportation were able to meet the clinical demands of blood component delivery (median time: 323 s [118–668 s]; temperature variation: 4.5–8.9°C for pRBCs and FFP and 21.5–23.5°C for cryoprecipitate and platelet units). Furthermore, parameters of pRBC quality, including the haemolysis index and potassium and lactate dehydrogenase levels in plasma, were not significantly different before and after transportation through RLTS. Similarly, RLTS transportation affected neither the basic coagulation test results in FFP and cryoprecipitate specimens nor platelet aggregation and activation markers in apheresis platelet specimens.ConclusionHospital‐wide delivery of blood components via RLTS seems to be safe, reliable and cost‐effective and does not have any negative impact on blood quality. Therefore, the establishment of standard criteria, protocols and guidelines based on further studies is needed.

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Section: Discussioncontrasting

confidence: 60%

“…In addition, several labile coagulation factors, such as FVIII and FV, have half-lives that are sensitive to PTS transportation conditions [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a rail logistics transmission system for the transportation of blood components within a medical centre

Chen,

Zang,

Wang

et al. 2023

Vox Sanguinis

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“…In another study conducted by Wang et al (2020), the ndings regarding the hemolysis rate showed one hemolyzed sample from a 500m-PTS group and a 40% hemolysis on samples from the 1000m-PTS group. Supplementarily, Nybo (2018) indicated an increase in the Hemolysis Index for most types of PTS stated in the study.…”

Section: Hematologymentioning

confidence: 94%

A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

Ausmolo

Pua

Abiog

et al. 2022

Preprint

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Introduction: Today, many hospitals use a Pneumatic Tube System (PTS) to quickly convey specimens to the lab. This study examined the clinical and practical impacts of PTS in delivering specimens. Blood chemistry and hematologic parameters were compared between PTS and manual transfer to determine whether there was a significant increase or decrease in its values. The study evaluated the following Blood Chemistry parameters such as LDH, K, AST, ALP, ALT, and Total Bilirubin and Hematologic parameters such as Red Cell indices (MCV, MHC, and MCHC), RBC count, Hemoglobin and Hematocrit, Hemolysis rate, and Platelet count. The data are gathered to evaluate if PTS provides the same specimen integrity as the manual technique. In this project, the researchers will conduct a systematic review utilizing the PRISMA 2020 reporting checklist. Methodology: Studies obtained from online databases were utilized. A set of criteria for selecting prospective studies were established. The studies should be published from 2017 to October 2022, must assess the effects of PTS by comparing them to manually transported samples, and must be fully accessible. Subgroup analysis and cumulative analysis were conducted to establish transparency of the results. Findings and Discussion: A total of 18 studies were evaluated. Three of these studies deal with blood chemistry, five with hematology, and ten with factors related to both blood chemistry and hematology. Among all the parameters evaluated, only LDH, potassium, and Hemolysis index showed clinical significance between the samples transported via PTS and manually delivered. The other chemistry parameters were also increased but were not clinically significant. Whereas, Hematologic parameters have only limited studies available that can show that it is of clinical significance. However, most included studies utilized a small sample size and limited population, restricting further analysis of the obtained results. Additionally, some were hindered due to insufficient data and information. Moreover, the technical aspects that can cause the results to differ are not provided because the PTS utilized to modify acceleration and deceleration, which are not sufficiently described. Some research claimed that their study was restricted to PTS effects alone.

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Investigation of the effects of pneumatic tube transport system on routine biochemistry, hematology, and coagulation tests in Ankara City Hospital

Yurt

Akbıyık

Bıçer

2022

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Academics are far from a consensus regarding the effects of pneumatic tube system (PTS) delivery on sample integrity and laboratory test results. As for the reasons for conflicting opinions, each PTS is uniquely designed, sample tubes and patient characteristics differ among studies. This study aims to validate the PTS utilized in Ankara City Hospital for routine chemistry, coagulation, and hematology tests by comparing samples delivered via PTS and porter. Methods The study comprises 50 healthy volunteers. Blood samples were drawn into three biochemistry, two coagulation, and two hemogram tubes from each participant. Each of the duplicate samples was transferred to the emergency laboratory via Swiss log PTS (aka PTS-immediately) or by a porter. The last of the biochemistry tubes were delivered via the PTS, upon completion of coagulation of the blood (aka PTS-after). The results of the analysis in these groups were compared with multiple statistical analyses. Results The study did not reveal any correlation between the PTS and serum hemolysis index. There were statistically significant differences in several biochemistry tests. However, none of them reached the clinical significance threshold. Basophil and large unidentified cell (LUC) tests had poor correlations (r=0.47 and r=0.60; respectively) and reached clinical significance threshold (the average percentages of bias, 10.2%, and 15.4%, respectively). The remainder of the hematology and coagulation parameters did not reach clinical significance level either. Conclusions The modern PTS validated in this study is safe for sample transportation for routine chemistry, coagulation, and hematology tests frequently requested in healthy individuals except for basophil and LUC.

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Falsely decreased FVIII activity following pneumatic tube transport

Cited by 4 publications

References 19 publications

Evaluation of a rail logistics transmission system for the transportation of blood components within a medical centre

Evaluation of a rail logistics transmission system for the transportation of blood components within a medical centre

A Systematic Review of the Impact of Pneumatic Tube System Transport on Blood Chemistry and Hematology Parameters

Investigation of the effects of pneumatic tube transport system on routine biochemistry, hematology, and coagulation tests in Ankara City Hospital

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