Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding

Yue, Wenjie; Liu, Yi; Jiang, Wen-An; Huang, Jianping; Liu, Jie

doi:10.1007/s10620-020-06420-1

Cited by 7 publications

(11 citation statements)

References 23 publications

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“…In our study, the rate of rebleeding was 14.72%, which is consistent with the literature ( Fukuda et al, 2020 ; Yue et al, 2021 ; Quentin et al, 2021 ). In most studies, the definition of rebleeding was consistent; however, the durations determined for this definition differed from each other.…”

Section: Discussionsupporting

confidence: 93%

“…Although peptic ulcer disease is the most common cause of UGIB in the literature, gastritis was observed more often than peptic ulcers in our study ( Oakland, 2019 ). Even though previous studies have shown no association between gastric ulcers or gastritis and rebleeding ( Yue et al, 2021 ), the rate of endoscopic diagnosis of peptic ulcers was found to be significantly high in patients with rebleeding, and the rate of diagnosis of gastritis was found to be significantly high in patients who showed no rebleeding.…”

Section: Discussioncontrasting

confidence: 66%

“…Several risk assessment tools and scores have been produced; however, their practical application is limited ( Stanley et al, 2017 ). By contrast, changes in UGIB etiology may have also changed the predictors of rebleeding ( Yue et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

Tatlıparmak¹,

Dikme²,

Dikme³

et al. 2022

PeerJ

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Background Rebleeding is associated with poor outcomes in upper gastrointestinal bleeding (UGIB). Identifying predictors of rebleeding can assist in risk assessment. The aim of the study is to investigate the factors affecting rebleeding in patients with UGIB admitted to the emergency department. Methods This retrospective, observational, cross-sectional study was conducted on patients with UGIB presented to the emergency department. Patients who did not arrest in the first 24 h, who were not diagnosed with GI malignancy, and who were clinically diagnosed with UGIB were included in the study. Patient demographic characteristics, hemodynamic parameters, patient parameters, and bleeding that may affect rebleeding were evaluated. The primary endpoint was rebleeding within 7 days. Results The study included 371 patients. A total of 55 patients (14.8%) had rebleeding within 7 days, and 62 patients (16.7%) presented without bleeding manifestations. Rebleeding rates were higher in those who presented with bloody or coffee-ground vomitus, had a diagnosis of cancer, had blood in their nasogastric tube, and had peptic ulcers due to endoscopy. Mean cell hemoglobin concentration, lymphocyte, albumin, and total protein values of patients with rebleeding were low; red blood cell distribution width, neutrophil count, platelet distribution width (PDW), and neutrophil lymphocyte ratio were high. In-hospital mortality and 30-day mortality values of patients with rebleeding were significantly increased. In the multivariate analysis, cancer, PDW, and total protein levels were statistically significant. Conclusion The presence of cancer, low total protein level, and high PDW are effective parameters in predicting 7-day rebleeding in patients with UGIB admitted to the emergency department.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 66%

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Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

Tatlıparmak¹,

Dikme²,

Dikme³

et al. 2022

PeerJ

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“…Patients who received freshly frozen plasma transfusions had significantly greater rates of overall complications, acute respiratory distress syndrome, and pneumonia (Zhang et al, 2017), which resulted in a relatively higher mortality rate among these patients. D-dimer, as a fibrinolytic activity monitor, is generally used to evaluate the overall fibrinolytic condition in UGIB patients (Yue et al, 2020). Patients were considered to have hyperfibrinolysis if they concomitantly had high values of D-dimer and t-PA activity (Violl et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Patients were considered to have hyperfibrinolysis if they concomitantly had high values of D-dimer and t-PA activity (Violl et al, 1996). Thus D-dimer is a stronger predictor for severity and prognosis both in Nonvariceal UGIB and variceal UGIB (Primignani et al, 2008;Yue et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Prediction model of emergency mortality risk in patients with acute upper gastrointestinal bleeding: a retrospective study

Chen

Zheng

Wang

2021

PeerJ

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Background Upper gastrointestinal bleeding is a common presentation in emergency departments and carries significant morbidity worldwide. It is paramount that treating physicians have access to tools that can effectively evaluate the patient risk, allowing quick and effective treatments to ultimately improve their prognosis. This study aims to establish a mortality risk assessment model for patients with acute upper gastrointestinal bleeding at an emergency department. Methods A total of 991 patients presenting with acute upper gastrointestinal bleeding between July 2016 and June 2019 were enrolled in this retrospective single-center cohort study. Patient demographics, parameters assessed at admission, laboratory test, and clinical interventions were extracted. We used the least absolute shrinkage and selection operator regression to identify predictors for establishing a nomogram for death in the emergency department or within 24 h after leaving the emergency department and a corresponding nomogram. The area under the curve of the model was calculated. A bootstrap resampling method was used to internal validation, and decision curve analysis was applied for evaluate the clinical utility of the model. We also compared our predictive model with other prognostic models, such as AIMS65, Glasgow-Blatchford bleeding score, modified Glasgow-Blatchford bleeding score, and Pre-Endoscopic Rockall Score. Results Among 991 patients, 41 (4.14%) died in the emergency department or within 24 h after leaving the emergency department. Five non-zero coefficient variables (transfusion of plasma, D-dimer, albumin, potassium, age) were filtered by the least absolute shrinkage and selection operator regression analysis and used to establish a predictive model. The area under the curve for the model was 0.847 (95% confidence interval [0.794–0.900]), which is higher than that of previous models for mortality of patients with acute upper gastrointestinal bleeding. The decision curve analysis indicated the clinical usefulness of the model. Conclusions The nomogram based on transfusion of plasma, D-dimer, albumin, potassium, and age effectively assessed the prognosis of patients with acute upper gastrointestinal bleeding presenting at the emergency department.

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Construction of a prediction model for rebleeding in patients with acute upper gastrointestinal bleeding

Zhuang,

Xia,

Chen

et al. 2023

Eur J Med Res

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Background The incidence of rebleeding in patients with upper gastrointestinal bleeding (UGIB) remains despite advances in intervention approaches. Therefore, early prediction of the risk of rebleeding could help to greatly reduce the mortality rate in these patients. We aim to develop and validate a new prediction model to predict the probability of rebleeding in patients with AUGIB. Methods A total of 1170 AUGIB patients who completed the procedure of emergency gastroscopy within 48 h of admission were included. Logistic regression analyses were performed to construct a new prediction model. A receiver operating characteristic curve, a line graph, and a calibration and decision curve were used to assess the predictive performance of our new prediction model and compare its performance with that of the AIMS65 scoring system to determine the predictive value of our prediction model. Results A new prediction model was constructed based on Lactic acid (LAC), neutrophil percentage (NEUTP), platelet (PLT), albumin (ALB), and D-DIMER. The AUC values and their 95% confidence interval (CI) for the new prediction model and the AIMS65 score were 0.746 and 0.619, respectively, and 0.697–0.795 and 0.567–0.670, respectively. In the training group, the C index values based on the prediction model and the AIMS65 scoring system were 0.720 and 0.610, respectively. In the validation group, the C index values based on the prediction model and the AIMS65 scoring system were 0.828 and 0.667, respectively. The decision and calibration curve analysis also showed that the prediction model was superior to the AIMS65 scoring system in terms of accuracy of prediction, consistency, and net clinical benefit. Conclusion The prediction model can predict the probability of rebleeding in AUGIB patients after endoscopic hemostasis therapy.

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Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding

Cited by 7 publications

References 23 publications

Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

Prediction model of emergency mortality risk in patients with acute upper gastrointestinal bleeding: a retrospective study

Construction of a prediction model for rebleeding in patients with acute upper gastrointestinal bleeding

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