Preadmission statin use improves the outcome of less severe sepsis patients - a population-based propensity score matched cohort study

Abstract

In this national cohort study, preadmission statin therapy before sepsis development was associated with a 12% reduction in mortality when compared with patients who never received a statin. There were no consistent beneficial effects of statins in all patient subgroups.

Simvastatin preparations promote PDGF‐BB secretion to repair LPS‐induced endothelial injury through the PDGFRβ/PI3K/Akt/IQGAP1 signalling pathway

“…Furthermore, new therapeutic targets are urgently needed. Statins, hydroxymethylglutaryl‐CoA reductase inhibitors, may have effects on inflammatory diseases such as sepsis and ARDS via its multiple properties, including an anti‐inflammatory effect and inhibition of leucocyte adhesion . Statins have become a controversial treatment for sepsis and infectious diseases in recent years .…”

“…Statins, hydroxymethylglutaryl-CoA reductase inhibitors, may have effects on inflammatory diseases such as sepsis and ARDS via its multiple properties, including an anti-inflammatory effect and inhibition of leucocyte adhesion. 35,36 Statins have become a controversial treatment for sepsis and infectious diseases in recent years. [36][37][38][39][40] Due to the poor water solubility and strong fat solubility of statins, NP carrier systems have been designed to enhance drug delivery, 41 and it has been confirmed that SV-NPs have good efficacy towards chronic inflammatory disorders such as atherosclerosis and chronic pulmonary disease.…”

“…35,36 Statins have become a controversial treatment for sepsis and infectious diseases in recent years. [36][37][38][39][40] Due to the poor water solubility and strong fat solubility of statins, NP carrier systems have been designed to enhance drug delivery, 41 and it has been confirmed that SV-NPs have good efficacy towards chronic inflammatory disorders such as atherosclerosis and chronic pulmonary disease. 29,42 The formulation of SV-NPs improves the pharmacokinetic profile and bioavailability of SV 43 ; it was also reported that nanostructured lipid carriers, especially those associated with SV, were able to reduce cytotoxicity.…”

Statin for Tuberculosis and Pneumonia in Patients with Asthma–Chronic Pulmonary Disease Overlap Syndrome: A Time-Dependent Population-Based Cohort Study

“…Our sensitivity analysis of propensity score–matched cohorts [ 54 ] revealed that statins were associated with a lower pneumonia and TB risks. This result may be explained by the different cohort and statistical methods used in the current research.…”

Perioperative statins surgery and postoperative pain

“…22 Pre-admission statin use has also been found to improve outcome in moderate sepsis in a large retrospective observational study. 23 There is also preliminary evidence showing the beneficial effects of restarting statins postoperatively. 24 Among 300 000 patients who had been taking statins before non-cardiac surgery, 30 day mortality was 40% greater (2.6%) in those patients who failed to restart their statin within 48 h postoperatively, compared with those who quickly resumed or never stopped taking their statin.…”