Perioperative statins surgery and postoperative pain

Sneyd, J. R.; Columb, Malachy O.; Nightingale, Tom E.

doi:10.1093/bja/aex248

Cited by 2 publications

(1 citation statement)

References 30 publications

(30 reference statements)

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“…3,4 To date, there have been very few clinical studies on the effects of statins on pain in the perioperative period. 5 A few studies have reported that perioperative statin use is not effective for reducing postoperative pain and opioid consumption. 6,7 Magnesium, which is a cofactor of all enzymes in phosphate-transfer reactions that utilize adenosine triphosphates as substrates, is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that blocks ion channels in a voltage-dependent manner.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Perioperative Use of a Statin–Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching

Lee

2020

Chonnam Med J

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Both statins and magnesium are associated with NMDA receptors and anti-inflammatory effect. Peripheral NMDA receptors are known to be involved in inflammationinduced pain. This study aimed to investigate the impact of perioperative use of a statinmagnesium combination on opioid consumption in patients who underwent cardiac surgery. This was a retrospective study of 542 patients who underwent cardiac surgery. The patients were divided into two groups according to statin use: the statin-magnesium group (n=375) and the magnesium-only group (n=167). Patients in the magnesium-only group received only perioperative magnesium, but no statins, to prevent atrial fibrillation following cardiac surgery. After propensity-score matching, 228 patients (n=114 in each group) were analyzed to investigate opioid consumption, visual analogue scale (VAS) pain scores over a 72-h period, and pain outcomes according to the duration of statin treatment (<1 or ≥1 yr). The consumed opioid volume was significantly smaller in statin-magnesium group than the magnesium-only group, both before (p=0.010) and after matching (p=0.017). The statin-magnesium combination did not significantly reduce the VAS pain scores compared with magnesium alone. Although the statin-magnesium combination did not significantly reduce the pain intensity compared with magnesium alone, the combination therapy was effective in reducing opioid consumption after surgery.

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