Pre-treatment serum levels of interleukin-10, interleukin-12 and their ratio predict response to therapy and probability of event-free and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias

IL-10 gene polymorphism and influence of chemotherapy on cytokine plasma levels in childhood acute lymphoblastic leukemia patients

“…At the time of diagnosis, IL-10 expression was higher in bone marrow ALL blasts [31,32], Treg cells from peripheral blood of ALL patients [33], and plasma/serum [29,34,35]. Contrariwise, Mazur, Mertas, Sonta-Jakimczyk, Szczepanski and Janik-Moszant [36] reported no differences in IL-10 concentrations among treated ALL children and controls.…”

Effect of probiotic strains mixture administration on serum interleukins concentration, lymphocyte proliferation and DNA damage in rams

“…Moreover, IL-10 is a macrophage-derived cytokine that down-regulates IFN-γ production, thus opposing the action of IL-12 on T cells and NK cells (D'Andrea et al, 1993). The IL-10/IL-12 ratio was frequently used in the assessment of immune status as a measure of the balance between antiinflammatory and pro-inflammatory state (Hamer et al, 2010), or Th1 vs Th2 dominance (Bien et al, 2009). The increased IL-10/IL-12 ratio, which was observed in this study, confirmed the potential antiinflammatory effect of probiotic and its possible role in modulating inflammatory conditions.…”

Interleukin-12 (IL-12)/IL-10 Ratio as a Marker of Disease Severity in Crimean-Congo Hemorrhagic Fever

“…The apparent opposing relationship that exists between the two interleukins has led to several studies successfully employing the ratio of these cytokines (usually IL-10/IL-12) in the assessment of immune status, e.g., as a measure of the balance between an anti-inflammatory and a proinflammatory state (2, 3, 6), or Th1 versus Th2 dominance (1).…”