Pre-transplant depression decreased overall survival of patients receiving allogeneic hematopoietic stem cell transplantation: a nationwide cohort study

Wang, Sheng‐Min; Park, Si-Hyun; Kim, Nak-Young; Kang, Dong Woo; Na, Hae-Ran; Lee, Jong Wook; Han, Seunghoon; Lim, Hyun Kook

doi:10.1038/s41598-020-71208-2

Cited by 13 publications

(10 citation statements)

References 33 publications

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confidence: 99%

“…Leukaemia is a life-threatening malignant neoplasm of the haematopoietic system ( 1 , 2 ). After a generalization phase in bone marrow and the appearance of leukaemic cells in the peripheral blood, extramedullary manifestations can occur in any organs of the body, including the skin ( 2 ). Findings in the skin of leukaemia patients are common and varied, such as nodular lesions, plaques, hyperpigmentation ( 3 , 4 ) or vasculitis ( 5 ).…”

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confidence: 99%

“…Findings in the skin of leukaemia patients are common and varied, such as nodular lesions, plaques, hyperpigmentation ( 3 , 4 ) or vasculitis ( 5 ). Non-specific cutaneous manifestations are mostly associated with abnormal haematopoiesis, such as thrombocytopenic purpura, incompetent granulocytopoiesis causing opportunistic infection including herpes zoster or fungal infection, and cutaneous paraneoplastic disease including pyoderma gangrenosum and insect-sting-like skin changes ( 2 , 6 , 7 ).…”

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confidence: 99%

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Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

Yook¹,

Son²,

Kim³

et al. 2022

Acta Derm Venereol

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Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic myeloid leukaemia, 2 chronic lymphocytic leukaemia, and 3 myelodysplastic syndrome). Male-female ratio 1.9:1, mean age at diagnosis 45.8 years. Plaques (28%) and papules (27%) were the most common skin lesions, followed by patches (18%) and nodules (16%). Mean time from diagnosis of leukaemia to development of leukaemia cutis was 12.3 months. Forty-six patients (84%) died during the 7-year follow-up; mean time from diagnosis of leukaemia cutis to death was 5.4 months. The results suggest that leukaemia cutis is associated with poor outcomes in patients with leukaemia. Comprehensive skin examination of these patients may help diagnose leukaemia cutis early, enabling prompt treatment.

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Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

Yook¹,

Son²,

Kim³

et al. 2022

Acta Derm Venereol

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“…A number of investigations have explored the impact of psychosocial risk factors on transplant-related mortality and morbidity, with conflicting results[ 18 , 25 , 26 ]. In a recent study, pre-transplant depression, particularly with comorbid anxiety, decreased the overall survival time after transplantation, while pre-transplant anxiety without depression had no impact on transplant-related mortality[ 27 , 28 ]. Psychological distress prior to HSCT is more likely to be manifested as severe anxiety than as depressive symptoms[ 13 , 29 ].…”

Section: Pre-transplantation Psychosocial Considerationsmentioning

confidence: 99%

Psychosocial aspects of hematopoietic stem cell transplantation

Janicsák

Ungvári

Gazdag

2021

WJT

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Hematopoietic stem cell transplantation (HSCT) has become a conventional and potentially curative treatment for various hematological diseases. As more sophisticated procedures have been developed and mortality rates have decreased, attention has shifted to the psychosocial challenges associated with transplantation. The psychosocial difficulties accompanying transplantation are addressed in the context of both quality of life (QOL) and psychopathological research. Among the psychiatric comorbidities of HSCT, anxiety, depression, sleep and sexual disorders, delirium and post-traumatic stress disorder are the most studied conditions. Recently, more attention has been focused on the psychosocial burden of caregivers. Devising recommendations for the management of psychiatric symptoms and psychosocial interventions in HSCT sufferers and close relatives is a major concern to consultation–liaison psychiatrists and transplant teams. This review synthesizes and critically evaluates the current literature on the psychosocial aspects of HSCT and appraises the clinical significance of these outcomes. Issues of QOL assessment; psychosocial functioning and QOL in the course of HSCT; impact of graft-versus-host disease and other predictors of QOL and psychosocial functioning; comorbid psychiatric disorders; and interventions to maintain or improve QOL and reduce psychopathology and psychosocial burden on family members are presented.

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“…In Korea, the Korean National Health Insurance Service (KNHIS) program is a mandatory public health insurance system that covers approximately 98% of the overall Korean population. The KNHIS database contains universal medical claims and mortality for the entire Korean population [11] and has been used in various epidemiological research studies on hematologic diseases, as described in detail elsewhere [12][13][14][15]. These strengths enable research on a nationwide cohort with the endpoint of identifying personal comorbidities related to patient prognosis after alloSCT.…”

Section: Introductionmentioning

confidence: 99%