Psychosocial aspects of hematopoietic stem cell transplantation

Janicsák, Henrietta; Ungvári, Gábor S.; Gazdag, Gábor

doi:10.5500/wjt.v11.i7.263

Cited by 25 publications

(23 citation statements)

References 95 publications

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“…In the last decade, there has been a significant increase in the number of patients undergoing HSCT, while the annual number is currently approximately 50,000 1 . There are two different types of HSCT: autologous and allogeneic [2][3][4] . Although the success rate of HSCT treatment is gradually increasing, the conditioning regimens consisting of intensive chemotherapy and/or radiotherapy given to these patients for 7-10 days before and after transplantation to prevent acute or chronic graft versus host disease cause many side effects 5,6 .…”

Section: Evaluation Of Pre-and Post-transplant Electroencephalographi...mentioning

confidence: 99%

Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients

Yavlal¹,

Güngen²,

Aras³

et al. 2023

Ideggyógyászati szemle

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Background and purpose – Haematopoietic stem cell transplantation (HSCT) is one of the most effective treatment methods for many malignant and non-malignant diseases. In this study, we aimed to detect electroencephalographic (EEG) anomalies at an early stage in patients who underwent allogeneic and autologous HSCT and required the management of potentially lifethreatening non-convulsive seizures. Methods – The study was conducted with 53 patients. The age, gender, HSCT type (allogeneic or autologous), and treatment regimens applied before and after HSCT were recorded. All patients underwent EEG monitoring twice, once on the first day of hospitalization and again one week after conditioning regimens began and HSCT was performed. Results – When the pre-transplant EEG findings were examined, 34 (64.2%) patients had normal EEGs and 19 (35.8%) had abnormal EEGs. After transplantation, 27 (50.9%) had normal EEG findings, 16 (30.2%) had a basic activity disorder, 6 (11.3%) had a focal anomaly, and 4 (7.5%) had a generalised anomaly. In the allogeneic group, the anomaly rate in post-transplant EEGs was significantly higher than that in the autologous group (p<0.05). Conclusion – It is important to consider the likelihood of epileptic seizures in the clinical follow-up of HSCT patients. EEG monitoring is crucial for the early diagnosis and treatment of such non-convulsive clinical manifestations.

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Section: Evaluation Of Pre-and Post-transplant Electroencephalographi...mentioning

confidence: 99%

Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients

Yavlal¹,

Güngen²,

Aras³

et al. 2023

Ideggyógyászati szemle

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“…Következtetés -Vizsgálati eredményeink szerint a graft versus host betegséggel összefüggő szomatikus panaszok talaján megjelenő depressziós és szorongásos tünetek az allogén betegeknél az életminőség romlásához vezetnek. Kulcsszavak: életminőség, pszichés tünetek, szorongás, depresszió, haematopoeticus őssejt-transzplantáció ing HSCT [9][10][11][12] . The conditioning regimen and transplant type have been reported to significantly impact the QOL and psychological symptoms of patients who have undergone HSCT 13,14 .…”

Section: Impact Of the Type Of Hematopoietic Stem-cell Transplant On ...unclassified

Impact of the type of hematopoietic stem-cell transplant on quality of life and psychopathology

Janicsák¹,

Reményi²,

Ungvari³

et al. 2023

Ideggyógyászati szemle

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Background and purpose – Despite the decrease in transplant-related mortality, patients who receive hematopoietic stemcell transplants often suffer from short-and long-term morbidities, poorer quality of life, and psychosocial functioning deficits. Several studies have compared the quality of life and affective symptoms of patients after undergoing autologous and allogeneic hematopoietic stem-cell transplants. Some studies have reported similar or greater quality of life impairments in allogeneic hematopoietic stemcell recipients, but the findings have been inconsistent. Our purpose was to examine the influence of the type of hematopoietic stem-cell transplantation on the quality of life and affective symptoms of patients. Methods – The study sample comprised 121 patients with various hematological diseases who underwent hematopoietic stem-cell transplantation at St. István and St. László Hospitals, Budapest. The study had a cross-sectional design. Quality of life was evaluated using the Hungarian version of the Functional Assessment of Cancer Therapy– Bone Marrow Transplant scale (FACT-BMT). Anxiety and depressive symptoms were assessed using Spielberger’s State and Trait Anxiety Inventory (STAI) and the Beck Depression Inventory (BDI), respectively. Basic sociodemographic and clinical variables were also recorded. Comparisons between autologous and allogeneic recipients were analyzed using a t-test when the variables were normally distributed and a Mann–Whitney U test otherwise. A stepwise multiple linear regression analysis was performed to identify the risk factors that contributed to the quality of life and the affective symptoms in each group. Results – Quality of life (p=0.83) and affective symptoms (pBDI=0.24; pSSTAI=0.63) were similar between the autologous and allogeneic transplant groups. The BDI scores of allogeneic transplant patients indicated mild depression, but their STAI scores were similar to those of the general population. Allogeneic transplant patients with symptoms of graft-versus-host disease (GVHD) experienced more severe clinical conditions (p=0.01), poorer functional status (p<0.01) and received more immunosuppressive treatment (p<0.01) than those without graft versus host disease. Patients suffering from graft versus host disease experienced more severe depression (p=0.01), and constant anxiety (p=0.03) than those without graft versus host disease. Quality of life was affected by depressive and anxiety symptoms and psychiatric comorbidity in both the allogeneic and autologous groups. Conclusion – Graft versus host disease-related severe somatic complaints seemed to influence the allogeneic transplant patients’ quality of life by inducing depressive and anxiety symptoms.

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“… 9 Caregivers report prominent feelings of distress, uncertainty, loneliness, fatigue, sleep disturbance, financial worry, and poor quality of life (QOL). 2 , 10 Many caregivers report feeling ill-prepared for their caregiver role and are overwhelmed by the uncertainty of their loved ones’ diagnosis. 2 , 5 These factors put caregivers at a greater risk of poor health outcomes and contribute to caregiver burden.…”

Section: Introductionmentioning

confidence: 99%

Coping in caregivers of patients with hematologic malignancies undergoing hematopoietic stem cell transplantation

et al. 2023

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Caregivers of patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) must cope with substantial caregiving burden, high rates of psychological distress, and diminished quality of life (QOL). However, data describing coping strategies pre-HSCT and the association between coping, QOL, and psychological outcomes in this population are lacking. We conducted a secondary analysis of data collected during a multi-site randomized clinical trial of a supportive care intervention in HSCT recipients and their caregivers. Caregivers completed the Brief COPE, Hospital Anxiety and Depression Scale, and the Caregiver Oncology Quality of Life Questionnaire to measure coping strategies, psychological distress, and QOL, respectively. We grouped coping into two higher order domains: approach-oriented (i.e., emotional support, active coping) and avoidant (i.e., self-blame, denial) We used the median split method to describe the distribution of coping and multivariate linear regression models to assess the relationship between coping and caregiver outcomes. We enrolled 170 caregivers, with a median (range) age of 53 (47-64) years. Most were White (87%), non-Hispanic (96%), and female (77%). Approach-oriented coping was associated with less anxiety (β=-0.210, p=0.003) and depression symptoms (β=-0.160, p=0.009), and better QOL (β=0.526, p=0.002). In contrast, avoidant coping was associated with more anxiety (β=0.687, p<0.001) and depression symptoms (β=0.579, p<0.001), and worse QOL (β=-1.631, p<0.001). Our findings suggest that coping is related to distress and QOL among caregivers of HSCT recipients even pre-transplant. Hence, caregivers of patients with hematologic malignancies undergoing HSCT may benefit from resources that facilitate adaptive coping with the demands of caregiving.

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Psychosocial aspects of hematopoietic stem cell transplantation

Cited by 25 publications

References 95 publications

Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients

Evaluation of pre- and post-transplant electroencephalographic examination in hematopoietic stem cell transplant patients

Impact of the type of hematopoietic stem-cell transplant on quality of life and psychopathology

Coping in caregivers of patients with hematologic malignancies undergoing hematopoietic stem cell transplantation

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