Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease

Wada, Hideki; Dohi, Tomotaka; Miyauchi, Katsumi; Shitara, Jun; Endo, Hirohisa; Doi, Shinichiro; Konishi, Hirokazu; Naito, Ryo; Tsuboi, Sadao; Ogita, Manabu; Kasai, Takatoshi; Hassan, Ahmed; Okazaki, Shinya; Isoda, Kikuo; Suwa, Satoru; Daida, Hiroyuki

doi:10.1016/j.atherosclerosis.2017.08.007

Cited by 52 publications

(44 citation statements)

References 29 publications

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“…[ 26 ] Lowering serum LDL-C and TG levels may improve the risk of vascular disease and reduce the incidence of acute coronary events. [ 27 ] In our study, serum TC, TG, LDL-c levels were significantly lower in the FN-MC group compared with the HFD group, while HDL-c levels were significantly elevated, similar to the PDC group.…”

Section: Discussionsupporting

confidence: 58%

Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats

et al. 2018

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BackgroundFragarianilgerrensis Schlecht. medicine compound (FN-MC) is a kind of Chinese herbs’ compound consisted of Fragarianilgerrensis Schlecht. and Centella asiatica (L.) Urban. The study was to investigate the hypolipidemia effect of FN-MC in a hypolipidemic rat model.MethodsMale SD rats were randomly divided into five groups: normal-fat diet (NFD) group, high-fat diet (HFD) group, FN-MC (2 g/Kg) group, FN-MC (4 g/Kg) group and simvastatin (PDC) group. After FN-MC treatment, body weight, food intake, serum and hepatic biochemistry parameters of rats were measured and the pathological changes of liver and its cells were observed by optical microscope and transmission electron microscopy.ResultsThe results showed that FN-MC significantly decreased the levels of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), apolipoprotein B (ApoB) and hepatic malondialdehyde (MDA), while increased serum high-density lipoprotein (HDL-C), apolipoprotein A1 (ApoA1) and hepatic Superoxide Dismutase (SOD). FN-MC also improved the structure of liver and decreased the lipid drops in the cytoplasm significantly. In addition, FN-MC significantly decreased the weight gain and had no significant effects on food intake.ConclusionsThe study suggested that FN-MC exhibited strong ability to improve the dyslipidemia and prevent hepatic fatty deposition in rats fed with high-fat diet. Meanwhile, FN-MC exerted anti-obesity and antioxidant properties.Highlights Fragarianilgerrensis Schlecht. medicine compound possesses a hypolipidemic effect on hyperlipidemic rat modelFragarianilgerrensis Schlecht. medicine compound administration improves the antioxidant capacity of ratsFragarianilgerrensis Schlecht. medicine compound prevents hepatic fatty deposition

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Section: Discussionsupporting

confidence: 58%

Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats

et al. 2018

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“…Yvan-Charvet et al found that ApoA1 inhibited the degree of leukocytosis to a certain extent, which inhibited the progression of atherosclerosis [29]. The combination of leukocyte subtypes or the combination of leukocyte subtypes with other indicators may be used as a predictor of prognosis in patients with CAD [30]. For example, the neutrophil-tolymphocyte ratio (NLR) is an independent predictor of long-term cardiovascular outcome after elective PCI [30].…”

Section: Discussionmentioning

confidence: 99%

“…The combination of leukocyte subtypes or the combination of leukocyte subtypes with other indicators may be used as a predictor of prognosis in patients with CAD [30]. For example, the neutrophil-tolymphocyte ratio (NLR) is an independent predictor of long-term cardiovascular outcome after elective PCI [30]. Arisoy A et al also found that the ratio of monocytes-to-high-density lipoprotein (MHR) was an independent predictor of increased thrombus burden after PCI in patients with STEMI [31].…”

Section: Discussionmentioning

confidence: 99%

Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: a retrospective cohort study

et al. 2020

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Background: Previous studies suggested that baseline white blood cell count and apolipoprotein A1 levels were associated with clinical outcomes in patients with coronary heart disease (CAD) who underwent percutaneous coronary intervention (PCI). However, the ratio of baseline white blood cell count-to-apolipoprotein A1 level (WAR) and CAD after PCI have not been investigated. The present study investigated the effects of baseline WAR on longterm outcomes after PCI in patients with CAD. Methods: A total of 6050 patients with CAD who underwent PCI were included in the study. Of these, 372 patients were excluded because no baseline white blood cell counts or apolipoprotein A1 (ApoA1) data was available or because of malignancies or other diseases. Finally, 5678 patients were enrolled in the present study and were divided into 3 groups according to WAR value: lower group-WAR< 5.25 (n = 1889); median group-5.25 ≤ WAR≤7.15 (n = 1892); and higher group-WAR≥7.15 (n = 1897). The primary endpoint was long-term mortality, including all-cause mortality (ACM) and cardiac mortality (CM), after PCI. The average follow-up time was 35.9 ± 22.6 months. Results: A total of 293 patients developed ACM, including 85 (4.5%) patients in the lower group, 90 (4.8%) patients in the median group, and 118 (6.2%) patients in the higher group. The risk of ACM, cardiac mortality (CM), major adverse cardiovascular and cerebrovascular events (MACCEs), and major adverse cardiovascular events (MACEs) increased 62.6% (hazard risk [

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“…In all our models MNA demonstrated to have an important impact on predicting mortality similar to specific cardiovascular characteristics. Recently, different studies have evaluated the role of nutritional status in patients undergoing PCI [22][23][24], indicating that nutritional status has a predictive value on outcome. Yoo et al [13], in a similar setting described that undernutrition has an important influence on clinical [25].…”

Section: Discussionmentioning

confidence: 99%

Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction

Komici¹,

Vitale²,

Mancini³

et al. 2018

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Background: Malnutrition is a frequent condition in the elderly and is associated with prolonged hospitalization and increased mortality. However, the impact of malnutrition among elderly patients with acute myocardial infarction has not been clarified yet. Methods and Results: We have enrolled 174 patients aged 65 years and over, admitted with the diagnosis of acute myocardial infarction (AMI) who underwent to the evaluation of nutritional status by Mini Nutritional Assessment (MNA) and of mortality risk by Grace score 2.0. All-cause mortality was the outcome considered for this study. Over a mean follow-up of 24.5 ± 18.2 months, 43 deaths have been registered (24.3%). Non-survivors were more likely to be older, with worse GFR, lower SBP, lower albumin and MNA score, higher prevalence of Killip classification III-IV grade, and higher Troponin I levels. Multivariate Cox proportional analysis revealed that Grace score and MNA showed a significant and independent impact on mortality, (HR = 1.76, 95% CI = 1.34–2.32 and HR = 0.56, 95% CI = 0.42–0.73, respectively). Moreover, the clinical decision curve revealed a higher clinical net benefit when the MNA was included compared to the partial models without MNA. Conclusions: Nutritional status is an independent predictor of long-term mortality among elderly patients with AMI. MNA score in elderly patients with AMI may help prognostic stratification and identification of patients with/at risk of malnutrition in order to apply interventions to improve nutritional status and maybe survival in this population.

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Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease

Cited by 52 publications

References 29 publications

Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats

Hypolipidemic effect of Fragarianilgerrensis Schlecht. medicine compound on hyperlipidemic rats

Baseline white blood cell count-to-apolipoprotein A1 ratio as a novel predictor of long-term adverse outcomes in patients who underwent percutaneous coronary intervention: a retrospective cohort study

Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction

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