Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction

Komici, Klara; Vitale, Dino Franco; Mancini, Angela; Bencivenga, Leonardo; Conte, Maddalena; Provenzano, Sandra; Grieco, Fabrizia; Visaggi, Lucia; Ronga, Ilaria; Corbi, Grazia; Trimarcö, Bruno; Morisco, Carmine; Leosco, Dario; Ferrara, Nicola; Rengo, Giuseppe

doi:10.20944/preprints201811.0311.v1

Cited by 2 publications

(2 citation statements)

References 24 publications

(28 reference statements)

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“…It is well established that malnutrition is associated with increased mortality in both acute and chronic disease, and this effect is still observed in older adults. The risk for both short-term mortality in acute conditions [ 54 ] as well as for long-term mortality in chronic disease is significantly increased [ 55 ]. One large cohort study included 1767 older individuals with a variety of disease ranging from cancer to diseases of the circulatory or respiratory system and revealed that the increased risk of mortality due to malnutrition existed irrespective of the cause of death [ 56 ].…”

Section: Impact Of Malnutrition In the Oldmentioning

confidence: 99%

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

2021

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Malnutrition in older adults has been recognised as a challenging health concern associated with not only increased mortality and morbidity, but also with physical decline, which has wide ranging acute implications for activities of daily living and quality of life in general. Malnutrition is common and may also contribute to the development of the geriatric syndromes in older adults. Malnutrition in the old is reflected by either involuntary weight loss or low body mass index, but hidden deficiencies such as micronutrient deficiencies are more difficult to assess and therefore frequently overlooked in the community-dwelling old. In developed countries, the most cited cause of malnutrition is disease, as both acute and chronic disorders have the potential to result in or aggravate malnutrition. Therefore, as higher age is one risk factor for developing disease, older adults have the highest risk of being at nutritional risk or becoming malnourished. However, the aetiology of malnutrition is complex and multifactorial, and the development of malnutrition in the old is most likely also facilitated by ageing processes. This comprehensive narrative review summarizes current evidence on the prevalence and determinants of malnutrition in old adults spanning from age-related changes to disease-associated risk factors, and outlines remaining challenges in the understanding, identification as well as treatment of malnutrition, which in some cases may include targeted supplementation of macro- and/or micronutrients, when diet alone is not sufficient to meet age-specific requirements.

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Section: Impact Of Malnutrition In the Oldmentioning

confidence: 99%

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

2021

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“…Although in univariate analysis the MPI score was significantly associated with 3-month all-cause mortality, our statistical model excluded this variable from the multivariate examination, in contrast to many scientific studies reporting that it is a robust prognostic factor in various geriatric clinical settings ( 21 - 22 ). However, the limited number of study participants might have affected the predictive efficacy of the MPI score.…”

Section: Discussionmentioning

confidence: 95%

IL-6 Levels Influence 3-Month All-Cause Mortality in Frail Hospitalized Older Patients

Rizza¹,

Morabito²,

Meo³

et al. 2021

Aging and disease

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The multidimensional prognostic index (MPI) is a sensitive and specific prognosis estimation tool that accurately predicts all-cause mortality in frail older patients. It has been validated to assess the risk of 1month to 2-year mortality in frail older patients during hospitalization and after hospital discharge. However, whether the MPI is a valid prognostic tool for follow-up periods of different lengths remains to be validated. To this end, we followed up 80 hospitalized patients (female=37, male 43) at least 75 years of age (mean age=82.6±4.4, range=75-94 years) to assess the 3-month all-cause mortality (mean follow-up=61.0 ± 31.7 months [range 4-90 days]). Accordingly, patients were subdivided into low (MPI-1, score 0-0.33), moderate (MPI-2, score 0.34-0.66) and high (MPI-3, score 0.67-1) mortality risk classes. Moreover, baseline biochemical, inflammatory and metabolic parameters, as well as anamnestic and clinical characteristics, were obtained. Although the MPI-3 score was significantly associated with 3-month all-cause mortality in univariate analysis (HR=5.79, 95%CI=1.77-18.92, p=0.004), a multivariate model indicated that only low albumin (HR=0.33, 95%CI=0.16-0.68, p=0.003) and high IL6 (HR=1.01, 95%CI=1.00-1.02, p=0.010) levels were significantly associated with 3month all-cause mortality. In conclusion, we suggest that measurement of IL6 as well as albumin, rather than the MPI score, may help in providing tailored therapeutic interventions to decrease short term mortality in older hospitalized individuals.

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Impact of Malnutrition on Long-Term Mortality in Elderly Patients with Acute Myocardial Infarction

Cited by 2 publications

References 24 publications

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

Malnutrition in Older Adults—Recent Advances and Remaining Challenges

IL-6 Levels Influence 3-Month All-Cause Mortality in Frail Hospitalized Older Patients

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