Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis

Abstract

Pre-pregnancy obesity is associated with adverse birth and pregnancy outcomes. Poor essential fatty acid and micronutrient status may contribute to this association. We assessed the association between pre-pregnancy body mass index (BMI) and micronutrient and essential fatty acid (EFA) status in mid-pregnancy. Women (n=129) provided non-fasting blood samples at ≤20 weeks gestation that were assayed for red blood cell EFA, plasma folate, plasma ascorbic acid, serum retinol, serum 25-hydroxyvitamin D, serum α-tocopherol, plasma homocysteine, serum soluble transferrin receptors, and serum carotenoids. Principal components analysis of these biomarker measures was used to construct three nutritional components: EFA, Micronutrient, and Carotenoid. Multivariable logistic regression was used to assess the independent effect of pre-pregnancy BMI on the likelihood of being in the lowest tertile of each nutritional component. After adjustment for parity, race/ethnicity, and age, obese pregnant women were 3.0 (95% CI: 1.1, 7.7) times as likely of being in the lowest tertile of the EFA component and 4.5 (95% CI: 1.7, 12.3) times as likely of being in the lowest tertile of the Carotenoid component as their lean counterparts. There was no association between obesity and Micronutrient component scores after confounder adjustment. Obese pregnant women may be vulnerable to having insufficient EFA and carotenoids concentrations, which may contribute to their elevated risk of adverse birth outcomes.

Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study

“…An inverse relation between pre-pregnancy BMI and folate, vitamin D, carotenoids has formerly been reported [10,11,13]. Our results have expanded this knowledge by reporting also lower levels of PLP (vitamin B6), riboflavin (vitamin B2), and cobalamin (vitamin B12) with higher pre-pregnancy BMI.…”

“…An inverse relation between pre-pregnancy BMI and several micronutrients like folate, vitamin D, carotenoids, zinc, and essential fatty acids have been reported in pregnant women, and negative pregnancy outcomes related to obesity might be related to impaired micronutrient status [10,11,12,13]. An adequate B vitamin status during pregnancy is important for maternal health and normal fetal development [14].…”

Efecto De Una Dieta Personalizada en Mujeres Embarazadas Con Sobrepeso U Obesidad

“…Una revisión de González-Moreno el año 2013 en México encontró una prevalencia de obesidad en mujeres embarazadas de 11-22% (4), similar a la prevalencia de 22.5% de nuestro estudio; en datos de ENSANUT 2012 se reportó que la prevalencia de sobrepeso en mujeres de 20-49 años era 35.3% y 35.2% de obesidad, cifras elevadas para lo encontrado en el presente estudio. El promedio de IMC pregestacional fue 28.5 kg/m2, a diferencia de lo mostrado por Tomedi en su estudio con mujeres embarazadas americanas donde el IMC pregestacional fue 26.6 kg/m2 (18), lo cual se relaciona con los incrementos alarmantes de casos de sobrepeso y obesidad en nuestro país (2).…”

Assessment of some nutritional blood parameters during pregnancy at southern Abobo hospital (Abidjan, Côte d’Ivoire)

“…4 Thus, nutritional status during pregnancy can partially influence outcome of pregnancy and birth. 5 It is therefore important to detect early nutritional dysfunction, so that women food consumption can be improved. To do this, it is possible to evaluate some substances present in tissues and fluids.…”