Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection

Thorburn, Kentigern

doi:10.1136/adc.2008.139188

Cited by 196 publications

(164 citation statements)

References 26 publications

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“…High rates of pre-existing co-morbidities have also been observed in children hospitalised for hMPV [37,75], although such data may be subject to selection bias, as they come from reference centres. Underlying disease, especially chronic lung disease of prematurity and haemodynamically significant congenital heart disease, is a significant predictor of prolonged hospitalisation, frequency of ICU admission and death in children hospitalised for RSV [107,109]. Conditions such as other symptomatic chronic pulmonary disorders, trisomy 21 and neuromuscular disease also increase the risk for severe disease [110][111][112].…”

Section: Risk Factors For Severe Diseasementioning

confidence: 99%

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Papenburg

Boivin

2010

Reviews in Medical Virology

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Acute respiratory tract infections (RTIs) are a leading cause of morbidity and mortality worldwide. Human Metapneumovirus (hMPV) is a member of the Metapneumovirus genus within the Pneumovirinae subfamily of the Paramyxoviridae family. Though hMPV was only discovered in 2001, a large body of work has already shown that it is the aetiologic agent of a substantial proportion of upper and lower RTIs across all age groups in both healthy and immunocompromised hosts throughout the world. RSV, also a pneumovirus, is the human pathogen most closely related to hMPV. RSV is the leading cause of pneumonia and bronchiolitis in infants and young children, but can also cause respiratory tract disease in all age groups. In this paper, we will review the salient features of the virology, epidemiology, pathogenesis, host immune responses, clinical manifestations and diagnostic modalities of hMPV, using RSV as a comparison. In addition, we will show how immunoprophylactic and therapeutic strategies studied and used in clinical practice for RSV-some with great success, and others tragic failure-have led to promising areas of research for the prevention and treatment of the significant burden of disease caused by hMPV.

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Section: Risk Factors For Severe Diseasementioning

confidence: 99%

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Papenburg

Boivin

2010

Reviews in Medical Virology

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“…Respiratuvar sinsisyal virüs enfeksiyonu geçiren dört (%25) hasta ileri solunum deste¤i için yo¤un bak›m birimine yat›r›ld›. Yo¤un bak›m birimine RSV enfeksiyonu nedeniyle yat›r›lan bebeklerin incelendi¤i bir çal›flmada ölüm oran›n›n %8,6 oldu¤u ve bu hastalar›n %29'unda kromozomal anomali, %27'sinde kalp malformasyonu, %15'inde nöromüsküler hastal›k, %12'sinde kronik akci¤er hastal›¤›, %9'unda havayolu anomalisi, %9'unda immün yetersizli¤in oldu¤u ve efllik eden durumlar›n ölümü anlaml› olarak artt›rd›¤› bildirilmifltir (28). Çal›flma grubumuzda yo¤un bak›m biriminde tedavi edilen hastalardan birinde bronkopulmoner displazi mevcuttu, kaybedilen hastam›z olmad›.…”

Section: Tart›flmaunclassified

Bronşiyolit tanısıyla izlenen küçük çocuklarda RSV sıklığı, klinik ve laboratuvar özellikleri

Kayıran¹,

Paloğlu²,

Gürakan³

2010

tpa

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B Br ro on nfl fli iy yo ol li it t t ta an n› ›s s› ›y yl la a i iz zl le en ne en n k kü üç çü ük k ç ço oc cu uk kl la ar rd da a R RS SV V s s› ›k kl l› ›¤ ¤› ›, , k kl li in ni ik k v ve e l la ab bo or ra at tu uv va ar r ö öz ze el ll li ik kl le er ri i T Th he e f fr re eq qu ue en nc cy y, , c cl li in ni ic ca al l a an nd d l la ab bo or ra at to or ry y f fe ea at tu ur re es s o of f R RS SV V i in n s sm ma al ll l c ch hi il ld dr re en n w wi it th h b br ro on nc ch hi io ol li it ti is s S Si in na an n M Ma ah hi ir r K Ka ay y› ›r ra an n, , E Er rh ha an n P Pa al lo o¤ ¤l lu u* *, , B Be er rk ka an n G Gü ür ra ak ka an n Bulgular: Nazofarengeal salg›da RSV antijeni bak›lan 79 hastan›n 16's›nda (%20) RSV pozitif saptand›. Bu hastalarda yafl, cinsiyet, ortalama gebelik haftas›, anne sütü ile beslenme süresi, vücut ›s›s›, lökosit say›s›, C-reaktif protein (CRP) düzeyi ve yat›r›larak tedavi oran›, RSV negatif hastalardan istatistiksel olarak farkl› bulunmad›. Hastalarda RSV enfeksiyonu en s›k Aral›k ay›nda saptand›. Respiratuvar sinsisyal virüs enfeksiyonu geçiren bebeklerin yo¤un bak›m biriminde yat›r›larak tedavi oran› RSV negatif hasta grubundan istatistiksel olarak anlaml› derecede yüksek bulundu. Ç›kar›mlar:Bronfliyolit tan›s›yla izlenen iki yafl alt› çocuklarda, RSV s›kl›¤› literatür ile uyumlu olarak %20 bulundu. Respiratuvar sinsisyal virüs enfeksiyonu hastaneye yat›fl oranlar›n› etkilememekle birlikte, RSV pozitif hastalarda solunum deste¤i ihtiyac› nedeniyle yo¤un bak›m biriminde tedavi oran›n›n RSV negatif hastalardan yüksek oldu¤u gözlendi. Bu nedenle bebeklerde ve riskli hasta grubunda RSV enfeksiyonunun a¤›r seyretmesi erken tan› ve koruyucu tedavinin önemini art›rmaktad›r. ( Results: Respiratory syncytial virus antigen in nasopharengeal secretions was positive in 16 (%20) of 79 patients. The age, sex, mean gestational week, duration of breast feeding, fever, mean leukocyte count, C-reactive protein (CRP) level and hospitalization rate were not significantly different between the RSV positive and negative patients. Respiratory syncytial virus infection was frequently detected in December. Intensive care unit admission for advanced respiratory support was found significantly higher in the RSV positive patients. Conclusions:Respiratory syncytial virus incidence in children younger than two years-old with the diagnosis of bronchiolitis was %20, concordant with the literature. Although hospitalization rate of RSV positive and negatif patients is similar, intensive care unit admission for advanced respiratory support was significantly higher in RSV positive patients. Therefore, as RSV infection in infants and high risk patients has a severe clinical course, this situation increases the importance of early diagnosis and prophylaxis. (Turk Arch Ped 2010; 45: 252-6)

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“…Hastalarda eşlik eden kronik hastalıkların varlı-ğının (konjenital kalp hastalığı gibi) RSV enfeksiyonlarının epidemiyolojik olarak sıklığını arttırmadığı, ancak hastalığın ciddiyetini ve mortalitesini arttırdığı bildirilmiştir (30,31) . Çalışmamızda, RSV negatif hastalarda eşlik eden kronik hastalıkların daha çok olduğu görülmüş ve benzer şekilde, eşlik eden kronik hastalıkların RSV enfeksiyonlarının sıklığını arttırmadığı saptanmıştır.…”

Section: Gereç Ve Yöntemunclassified

Çocuklarda Respiratuvar Sinsityal Virüs (RSV) Enfeksiyonlarının Tanısında Hücre Kültürü ve Direkt Floresan Antikor Testi Yöntemlerinin Karşılaştırılması

Sağlık¹,

Mutlu²,

Öngüt³

et al. 2015

TMCD

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Araştırma ÖZET Amaç: Çocukluk çağında sıklıkla görülen enfeksiyon hastalıklarından biri olan alt solunum yolu enfeksiyonlarının (ASYE) en sık etkeni respiratuvar sinsityal virüs (RSV)'tür. Bu çalışmanın amacı ASYE tanısı alan 0-5 yaş grubundaki çocuklarda RSV'nin hücre kültürü ve direkt floresan antikor (DFA) yöntemleri ile araştırılması ve sonuçların hastaların klinik bulguları ile birlikte değerlendirilmesidir. Gereç ve Yöntem: ASYE tanısı alan 0-5 yaş arasındaki 107 ayaktan (poli-klinik Objective: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections (LRTI) in children. This study was aimed to investigate the presence of RSV by cell culture and direct fluorescent antibody (DFA) methods in children with LRTI and to evaluate the results in association with the clinical findings of the patients. Materials and Methods: The study included 162 children with LRTI. The age group of the cases was 0-5 years old, of which 107 were outpatients and 55 were inpatients. Nasopharyngeal swab samples were obtained by flocked swabs and transported to the laboratory within the viral transport medium (Copan Diagnostics, Brescia, Italy). Samples were inoculated into the shell-vial cell culture prepared with A549 cells and presence of RSV were investigated in the fixed cells by fluorescence-labeled monoclonal antibodies (Anti-RSV

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Pre-existing disease is associated with a significantly higher risk of death in severe respiratory syncytial virus infection

Cited by 196 publications

References 26 publications

The distinguishing features of human metapneumovirus and respiratory syncytial virus

The distinguishing features of human metapneumovirus and respiratory syncytial virus

Bronşiyolit tanısıyla izlenen küçük çocuklarda RSV sıklığı, klinik ve laboratuvar özellikleri

Çocuklarda Respiratuvar Sinsityal Virüs (RSV) Enfeksiyonlarının Tanısında Hücre Kültürü ve Direkt Floresan Antikor Testi Yöntemlerinin Karşılaştırılması

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