2016
DOI: 10.1016/s0140-6736(15)00070-7
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Pre-eclampsia

Abstract: Pre-eclampsia affects 3-5% of pregnancies and is traditionally diagnosed by the combined presentation of high blood pressure and proteinuria. New definitions also include maternal organ dysfunction, such as renal insufficiency, liver involvement, neurological or haematological complications, uteroplacental dysfunction, or fetal growth restriction. When left untreated, pre-eclampsia can be lethal, and in low-resource settings, this disorder is one of the main causes of maternal and child mortality. In the absen… Show more

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Cited by 1,403 publications
(1,152 citation statements)
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References 135 publications
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“…AKI and preeclampsia (PE) may lead to subsequent CKD, but quantification of this risk is not known. PE is a risk factor for the future development of CKD and end-stage renal disease (ESRD) in the mother [3], and is the principal cause of AKI and maternal death in developing countries [4]. Furthermore, PE is linked to 'small babies', who are at risk for developing diabetes, metabolic syndrome, cardiovascular diseases (CVDs) and CKD in adulthood [5].…”
Section: Pregnancymentioning
confidence: 99%
“…AKI and preeclampsia (PE) may lead to subsequent CKD, but quantification of this risk is not known. PE is a risk factor for the future development of CKD and end-stage renal disease (ESRD) in the mother [3], and is the principal cause of AKI and maternal death in developing countries [4]. Furthermore, PE is linked to 'small babies', who are at risk for developing diabetes, metabolic syndrome, cardiovascular diseases (CVDs) and CKD in adulthood [5].…”
Section: Pregnancymentioning
confidence: 99%
“…PE is a risk factor for the future development of CKD and ESRD in the mother (3)(4)(5). The reasons are not fully understood; podocyte loss is a hallmark of PE, suggesting permanent glomerular damage (25).…”
Section: There Are Long Term Effects Of Pe On Both Maternal and Fetalmentioning
confidence: 99%
“…Besides maternal risks, PE is associated with intrauterine and perinatal death, preterm delivery, and restricted intrauterine growth; the latter two are linked to "small babies" (2,3,5).…”
Section: There Are Long Term Effects Of Pe On Both Maternal and Fetalmentioning
confidence: 99%
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“…A normal calcium level during pregnancy will prevent occurrence of hypertensive disorders and pre-eclampsia [13,14]. In regions where calcium-deficient diets are not a concern, supplementation is not recommended while in all others a dose of 1.5-2.0 g oral elemental calcium should be taken divided in three doses, taken with meals and several hours apart from iron supplements as the negative interactions could occur between the two supplements [6].…”
Section: Calcium and Vitamin Dmentioning
confidence: 99%