Pre-coating of protein modulate patterns of corona formation, physiological stability and cytotoxicity of silver nanoparticles

Bhargava, Arpit; Dev, Atul; Mohanbhai, Soni Jignesh; Pareek, Vikram; Jain, N. K.; Choudhury, Subhasree Roy; Panwar, Jitendra; Karmakar, Surajit

doi:10.1016/j.scitotenv.2020.144797

Cited by 24 publications

(8 citation statements)

References 58 publications

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“…It can be suggested that pre-coating of NPs with proteins probably regulate the PC composition, stability of NPs [110], their macrophage uptake [111,112], targeting specificity [113], dynamics of protein adsorption [114], cellular uptake [115], and their cytotoxicity [116]. Indeed, pre-coating of NPs can enable the scientists to design the PC which offers the probability to control cellular uptake.…”

Section: Protein Pre-coatingmentioning

confidence: 99%

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan

Sharifi

Gleghorn

et al. 2022

Journal of Controlled Release

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Section: Protein Pre-coatingmentioning

confidence: 99%

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan

Sharifi

Gleghorn

et al. 2022

Journal of Controlled Release

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“…Furthermore, as compared with their PVP counterparts, citrate‐coated AgNPs had a stronger interaction with BSA, demonstrating that the surface composition overshadowed the influence of the core NP, thereby dictating NP's interaction and behavior. Recently published articles also demonstrated the AgNP's stability in the biological milieu aided by the creation of coronas; however, this effect was attenuated in case of protein‐precoated AgNPs, thereby significantly affecting the cytotoxic effect induced (Bhargava et al, 2021). Similar studies by other authors on different cell lines have also indicated the importance of PC, implying that the lack of a NP–PC complex results in NP aggregation, thus elevating the toxicity (Barbalinardo et al, 2018; Spagnoletti et al, 2021; Zhao et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review

Suthar

Vaidya

Ravindran

2022

J of Applied Toxicology

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Silver nanoparticles have many medical and commercial applications, but their effects on human health are poorly understood. They are used extensively in products of daily use, but little is known about their potential neurotoxic effects. A xenobiotic metal, silver, has no known physiological significance in the human body as a trace metal. Biokinetics of silver nanoparticles indicates its elimination from the body via urine and feces route. However, a substantial amount of evidence from both in vitro and in vivo experimental research unequivocally establish the fact of easier penetration of smaller nanoparticles across the blood–brain barrier to enter in brain and thereby interaction with cellular components to induce neurotoxic effects. Toxicological effects of silver nanoparticles rely on the degree of exposure, particle size, surface coating, and agglomeration state as well as the type of cell or organism used to evaluate its toxicity. This review covers pertinent facts and the present state of knowledge about the neurotoxicity of silver nanoparticles reviewing the impacts on oxidative stress, neuroinflammation, mitochondrial function, neurodegeneration, apoptosis, and necrosis. The effect of silver nanoparticles on the central nervous system is a topic of growing interest and concern that requires immediate consideration.

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“…The silver nanoparticle LCs variation previously reported may occur due to the different nanoparticle physicochemical characteristics and also because of the molecules involved in the nanoparticle synthesis and capping. The molecules from extracts or even adhered to the biogenic nanoparticle can directly influence the biological action, affecting the toxicity [ 32 , 33 ]. The LC 50 value (0.691 mg mL −1 ) of the silver nanoparticles was higher compared to Roni et al (2015) (26.47 mg L −1 ) [ 11 ], and within the range compared to Ali et al, (2019) [ 31 ] (0.337–0.729 mg mL −1 ).…”

Section: Resultsmentioning

confidence: 99%

Entomopathogenic Fungi-Mediated AgNPs: Synthesis and Insecticidal Effect against Plutella xylostella (Lepidoptera: Plutellidae)

Santos

Varize²,

Jain

et al. 2022

Materials

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The insect Plutella xylostella is known worldwide to cause severe damage to brassica plantations because of its resistance against several groups of chemicals and pesticides. Efforts have been conducted to overcome the barrier of P. xylostella genetic resistance. Because of their easy production and effective insecticidal activity against different insect orders, silver nanoparticles are proposed as an alternative for agricultural pest control. The use of entomopathogenic fungi for nanoparticle production may offer additional advantages since fungal biomolecules may synergistically improve the nanoparticle’s effectiveness. The present study aimed to synthesize silver nanoparticles using aqueous extracts of Beauveria bassiana, Metarhizium anisopliae, and Isaria fumosorosea isolates and to evaluate their insecticidal activity against P. xylostella, as innovative nano-ecofriendly pest control. The produced silver nanoparticles were evaluated by measuring the UV–vis spectrum and the mean particle size by dynamic light scattering (DLS). I. fumosorosea aqueous extract with 3-mM silver nitrate solution showed the most promising results (86-nm mean diameter and 0.37 of polydispersity). Scanning electron microscopy showed spherical nanoparticles and Fourier-Transform Infrared Spectroscopy revealed the presence of amine and amide groups, possibly responsible for nanoparticles’ reduction and stabilization. The CL50 value of 0.691 mg mL−1 was determined at 72-h for the second-instar larvae of the P. xylostella, promoting a 78% of cumulative mortality rate after the entire larval stage. From our results, the synthesis of silver nanoparticles mediated by entomopathogenic fungi was successful in obtaining an efficient product for insect pest control. The I. fumosorosea was the most suitable isolate for the synthesis of silver nanoparticles contributing to the development of a green nanoproduct and the potential control of P. xylostella.

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Pre-coating of protein modulate patterns of corona formation, physiological stability and cytotoxicity of silver nanoparticles

Cited by 24 publications

References 58 publications

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Toxic implications of silver nanoparticles on the central nervous system: A systematic literature review

Entomopathogenic Fungi-Mediated AgNPs: Synthesis and Insecticidal Effect against Plutella xylostella (Lepidoptera: Plutellidae)

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