Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain—A primate study

Hynynen, Kullervo; McDannold, Nathan; Clement, Gregory T.; Jólesz, Ferenc A.; Zadicario, Eyal; Killiany, Ronald J.; Moore, Tara; Rosen, D.

doi:10.1016/j.ejrad.2006.04.007

Cited by 212 publications

(145 citation statements)

References 24 publications

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“…Clement and Hynynen (2002b) took the next step to perform three-dimensional aberration correction through ten human ex vivo skulls based on the acoustic properties derived from CT images. Hynynen et al (2006) have pursued this work further, recently demonstrating the ability to transcranially produce lesions in primates. While this appears to be a very successful technique, it requires the use of a second (ionizing) modality and the accompanying registration between the modalities.…”

Section: Introduction and Literaturementioning

confidence: 99%

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Haworth

Fowlkes

Carson

et al. 2008

Ultrasound in Medicine & Biology

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We report on the first experiments demonstrating the transcranial acoustic formation of stable gas bubbles that can be used for transcranial ultrasound aberration correction. It is demonstrated that the gas bubbles can be formed transcranially by phase-transitioning single, superheated, micron-size, liquid dodecafluoropentane droplets with ultrasound, a process known as acoustic droplet vaporization (ADV). ADV was performed at 550 kHz, where the skull is less attenuating and aberrating, allowing for higher-amplitudes to be reached at the focus. Additionally, it is demonstrated that time-reversal focusing at 1 MHz can be used to correct for transcranial aberrations with a single gas bubble acting as a point beacon. Aberration correction was performed using a synthetic aperture approach and verified by the realignment of the scattered waveforms. Under the conditions described below, time-reversal aberration correction using gas bubbles resulted in a gain of 1.9 ± 0.3 in an introduced focusing factor. This is a small fraction of the gain anticipated from complete transmitreceive of a fully-populated two-dimensional array with sub-wavelength elements.

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Section: Introduction and Literaturementioning

confidence: 99%

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Haworth

Fowlkes

Carson

et al. 2008

Ultrasound in Medicine & Biology

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show abstract

“…[7] . 그러나 최근, 두개골 내 효과적인 초음파 에너지 전달을 위해 빔 왜곡 교정을 위한 phased array 개발, CT 영상을 이용한 왜곡의 보상 등 초음파 뇌 수술의 가능성을 높일 수 있는 주요 진전이 이루어지고 있다 [8] .…”

Section: ⅰ 서 론unclassified

Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound

민정화¹,

김주영²,

노시철³

et al. 2013

Journal of the Korean Society of Radiology

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In this study, human head-mimicking phantom was developed for brain disease treatment study using focused ultrasound. Acoustic parameters of skin, skull and brain were investigated through literature investigation and adequate substitutes according to each tissue were suggested. In the case of skin phantom, construction ratio of glycerol-based TMM phantom was controlled to mimic real skin. The suitability of skull substitutes was evaluated through measurement of acoustic parameters. In the case of brain phantom, transparent egg white phantom was used to observe thermal properties of focused ultrasound. Combined human-head-mimicking phantom using each substitutes was fabricated for development of brain disease treatment protocol. Denaturation of brain phantom according to ultrasonic condition was observed for validation.

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“…Phased arrays can be used for correcting or compensating for phase distortions due to tissue inhomogeneities or bone (24)(25)(26). An example of this is a device designed to ablate brain tumors through the intact skull.…”

Section: Noninvasive Energy Delivery By Focused Ultrasoundmentioning

confidence: 99%

MRI-Guided Focused Ultrasound Surgery

2007

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MRI-guided focused ultrasound (MRgFUS) surgery is a noninvasive thermal ablation method that uses magnetic resonance imaging (MRI) for target definition, treatment planning, and closed-loop control of energy deposition. Integrating FUS and MRI as a therapy delivery system allows us to localize, target, and monitor in real time, and thus to ablate targeted tissue without damaging normal structures. This precision makes MRgFUS an attractive alternative to surgical resection or radiation therapy of benign and malignant tumors. Already approved for the treatment of uterine fibroids, MRgFUS is in ongoing clinical trials for the treatment of breast, liver, prostate, and brain cancer and for the palliation of pain in bone metastasis. In addition to thermal ablation, FUS, with or without the use of microbubbles, can temporarily change vascular or cell membrane permeability and release or activate various compounds for targeted drug delivery or gene therapy. A disruptive technology, MRgFUS provides new therapeutic approaches and may cause major changes in patient management and several medical disciplines.

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Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain—A primate study

Cited by 212 publications

References 24 publications

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Towards Aberration Correction of Transcranial Ultrasound Using Acoustic Droplet Vaporization

Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound

MRI-Guided Focused Ultrasound Surgery

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