Development of Human-Head-Mimicking Phantom for Brain Treatment Using Focused Ultrasound

Abstract

In this study, human head-mimicking phantom was developed for brain disease treatment study using focused ultrasound. Acoustic parameters of skin, skull and brain were investigated through literature investigation and adequate substitutes according to each tissue were suggested. In the case of skin phantom, construction ratio of glycerol-based TMM phantom was controlled to mimic real skin. The suitability of skull substitutes was evaluated through measurement of acoustic parameters. In the case of brain phantom, transparent egg white phantom was used to observe thermal properties of focused ultrasound. Combined human-head-mimicking phantom using each substitutes was fabricated for development of brain disease treatment protocol. Denaturation of brain phantom according to ultrasonic condition was observed for validation.

Heating Characteristics Evaluation of Superposed Sonication Using Glycerol Tissue Mimic Phantom

“…캐비테 이션 발생에 대한 연구 중 서로 다른 두 개의 초음파 를 교차시키면 중첩 현상에 의하여 캐비테이션 발생 량이 증가하고 [3], [4] , 열 상승 효과도 향상된다는 다양한 연구가 보고되었는데 [5], [6] , 추세이다 [7], [8] . 글리세롤 기반 초음파 조직 유사 팬텀은 IEC 60601-2-37에 명시되어 있는 초음파 연부 조직 유사 팬텀 제 작 기준규격을 이용하여 제작하였다 [9] . 팬텀의 크기는 70 mm × 70 mm × 40 mm로 제작하였으며, 음속은 1,5 38.7 m/s, 감쇠계수는 0.56 dB/cm·MHz로 측정되었다.…”