Abstract:According to predictive processing theories of perception, the brain generates predictions to prepare for sensory input, and calibrates certainty of predictions based on their likelihood. When an input doesn't match the prediction, an error signal leads to updating of the predictive model. Prior research suggests altered prediction certainty in autism, but predictive processing occurs across the cortical hierarchy, and the stage(s) of processing where prediction certainty breaks down is unknown. We therefore t… Show more
“…To summarize, disrupted encoding of global and local oddballs speaks to the utility of this paradigm to uncover neural computations and interactions that are relevant for diseased states. The relationship between P300/MMN and cognitive functioning in disorders 17,50,[101][102][103][113][114][115][116] as well as imbalanced beta/gamma oscillatory states 107,113 in psychopathy, ASD, depression, and ScZ points to the importance of understanding these phenomena at a neuronal level and indicates the possibility of using neural data as biomarkers. With further development, it could be possible to design specific medications and treatments to specifically alter these biomarkers, helping to treat these disorders.…”
The brain is thought to generate internal predictions. The local-global oddball paradigm has been used to investigate predictive coding. Local oddballs are created by stimulus repetition and can be explained by release from adaptation. Global oddballs are created by higher-order patterns that cannot be explained by low-level mechanisms. Initial neuroimaging experiments revealed local/global oddball activation of sensory and higher-order networks. Recent studies of spiking in sensory areas show no response to global oddballs – a challenge to predictive coding. We propose a conceptual framework, predictive routing. In predictive routing, not all feedforward sensory responses are prediction errors. Instead, alpha/beta oscillations provide predictive suppression at the appropriate level of processing. We apply this model to autism spectrum disorder (ASD) and schizophrenia (ScZ).
“…To summarize, disrupted encoding of global and local oddballs speaks to the utility of this paradigm to uncover neural computations and interactions that are relevant for diseased states. The relationship between P300/MMN and cognitive functioning in disorders 17,50,[101][102][103][113][114][115][116] as well as imbalanced beta/gamma oscillatory states 107,113 in psychopathy, ASD, depression, and ScZ points to the importance of understanding these phenomena at a neuronal level and indicates the possibility of using neural data as biomarkers. With further development, it could be possible to design specific medications and treatments to specifically alter these biomarkers, helping to treat these disorders.…”
The brain is thought to generate internal predictions. The local-global oddball paradigm has been used to investigate predictive coding. Local oddballs are created by stimulus repetition and can be explained by release from adaptation. Global oddballs are created by higher-order patterns that cannot be explained by low-level mechanisms. Initial neuroimaging experiments revealed local/global oddball activation of sensory and higher-order networks. Recent studies of spiking in sensory areas show no response to global oddballs – a challenge to predictive coding. We propose a conceptual framework, predictive routing. In predictive routing, not all feedforward sensory responses are prediction errors. Instead, alpha/beta oscillations provide predictive suppression at the appropriate level of processing. We apply this model to autism spectrum disorder (ASD) and schizophrenia (ScZ).
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