Pre and Probiotics Involved in the Modulation of Oral Bacterial Species: New Therapeutic Leads in Mental Disorders?

Maitre, Yoann; Mahalli, Rachid; Micheneau, Pierre; Delpierre, Alexis; Guerin, Marie; Amador, Gilles; Denis, Frédéric

doi:10.3390/microorganisms9071450

Cited by 14 publications

(13 citation statements)

References 95 publications

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“…Nutraceuticals are known for their health benefits: reduction of the risk of cancer and heart disease, but also the prevention or treatment of hypertension, hypercholesterolemia, overweight, osteoporosis, diabetes, arthritis, digestive disorders, and constipation, not to mention headaches [ 57 , 58 , 59 ]. It was shown that nutraceuticals may have therapeutic properties such as anti-inflammatory and antibacterial effects that may be beneficial for the treatment of periodontitis [ 60 ].…”

Section: Perspectivesmentioning

confidence: 99%

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Martin

Foulon

El‐Hage

et al. 2022

IJMS

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The study aimed to examine the impact of the oropharyngeal microbiome in the pathophysiology of schizophrenia and to clarify whether there might be a bidirectional link between the oral microbiota and the brain in a context of dysbiosis-related neuroinflammation. We selected nine articles including three systemic reviews with several articles from the same research team. Different themes emerged, which we grouped into 5 distinct parts concerning the oropharyngeal phageome, the oropharyngeal microbiome, the salivary microbiome and periodontal disease potentially associated with schizophrenia, and the impact of drugs on the microbiome and schizophrenia. We pointed out the presence of phageoma in patients suffering from schizophrenia and that periodontal disease reinforces the role of inflammation in the pathophysiology of schizophrenia. Moreover, saliva could be an interesting substrate to characterize the different stages of schizophrenia. However, the few studies we have on the subject are limited in scope, and some of them are the work of a single team. At this stage of knowledge, it is difficult to conclude on the existence of a bidirectional link between the brain and the oral microbiome. Future studies on the subject will clarify these questions that for the moment remain unresolved.

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Section: Perspectivesmentioning

confidence: 99%

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Martin

Foulon

El‐Hage

et al. 2022

IJMS

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“…Its use could help to reduce oral dysbiosis linked to PD [ 81 ] and its impacts on AD patients. Probiotic strains affecting the periodontogenic flora through various galenic forms, such as milk drinks, yoghurts, and mouthwash could facilitate oral hygiene measures in AD patients [ 82 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

Maitre

Mahalli

Micheneau

et al. 2021

IJERPH

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This review aims to clarify the nature of the link between Alzheimer’s disease and the oral microbiome on an epidemiological and pathophysiological level, as well as to highlight new therapeutic perspectives that contribute to the management of this disease. We performed a systematic review, following the Preferred Reporting Items for Systematic Reviews checklist, from January 2000 to July 2021. The terms “plaque,” “saliva,” and “mouth” were associated with the search term “oral diseases” and used in combination with the Boolean operator “AND”/”OR”. We included experimental or clinical studies and excluded conferences, abstracts, reviews, and editorials. A total of 27 articles were selected. Evidence for the impact of the oral microbiome on the pathophysiological and immunoinflammatory mechanisms of Alzheimer’s disease is accumulating. The impact of the oral microbiome on the development of AD opens the door to complementary therapies such as phototherapy and/or the use of prebiotic compounds and probiotic strains for global or targeted modulation of the oral microbiome in order to have a favourable influence on the evolution of this pathology in the future.

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“…Recently there has been renewed interest in understanding microbial behavior in natural habitats. Many chronic diseases can have complex etiologies (sometimes not conforming to classic Koch postulates) and there is mounting evidence for microbial interventions in a plethora of pathologies in the human host ( Thomas et al, 2021 ), many of which are potentially either instigated or sustained by dysbiosis within the oral microbiome ( Le Bars et al, 2017 ; Tiwari et al, 2020 ; Maitre et al, 2021b ; Nguyen et al, 2021 ; Todorov et al, 2021 ; Gao et al, 2022 ; Rismayuddin et al, 2022 ; Sankarapandian et al, 2022 ). We all harbor personalized microbiomes based within our oral cavity biofilms, the balanced operations of which are a critical factor in our health status within the mouth -and beyond.…”

Section: Future Prospects For Oral Probioticsmentioning

confidence: 99%

Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics

Tagg¹,

Harold²,

Jain³

et al. 2023

Front. Microbiol.

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The human oral cavity contains a diversity of microbial habitats that have been adopted and adapted to as homeland by an amazingly heterogeneous population of microorganisms collectively referred to as the oral microbiota. These microbes generally co-habit in harmonious homeostasis. However, under conditions of imposed stress, as with changes to the host’s physiology or nutritional status, or as a response to foreign microbial or antimicrobial incursions, some components of the oral “microbiome” (viz. the in situ microbiota) may enter a dysbiotic state. This microbiome dysbiosis can manifest in a variety of guises including streptococcal sore throats, dental caries, oral thrush, halitosis and periodontal disease. Most of the strategies currently available for the management or treatment of microbial diseases of the oral cavity focus on the repetitive “broad sweep” and short-term culling of oral microbe populations, hopefully including the perceived principal pathogens. Both physical and chemical techniques are used. However, the application of more focused approaches to the harnessing or elimination of key oral cavity pathogens is now feasible through the use of probiotic strains that are naturally adapted for oral cavity colonization and also are equipped to produce anti-competitor molecules such as the bacteriocins and bacteriocin-like inhibitory substances (viz BLIS). Some of these probiotics are capable of suppressing the proliferation of a variety of recognized microbial pathogens of the human mouth, thereby assisting with the restoration of oral microbiome homeostasis. BLIS K12 and BLIS M18, the progenitors of the BLIS-producing oral probiotics, are members of the human oral cavity commensal species Streptococcus salivarius. More recently however, a number of other streptococcal and some non-streptococcal candidate oral probiotics have also been promoted. What is becoming increasingly apparent is that the future for oral probiotic applications will probably extend well beyond the attempted limitation of the direct pathological consequences of oral microbiome dysbiosis to also encompass a plethora of systemic diseases and disorders of the human host. The background to and the evolving prospects for the beneficial modulation of the oral microbiome via the application of BLIS-producing S. salivarius probiotics comprises the principal focus of the present review.

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Pre and Probiotics Involved in the Modulation of Oral Bacterial Species: New Therapeutic Leads in Mental Disorders?

Cited by 14 publications

References 95 publications

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Is There a Link between Oropharyngeal Microbiome and Schizophrenia? A Narrative Review

Evidence and Therapeutic Perspectives in the Relationship between the Oral Microbiome and Alzheimer’s Disease: A Systematic Review

Beneficial modulation of human health in the oral cavity and beyond using bacteriocin-like inhibitory substance-producing streptococcal probiotics

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