Pre- and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two-Center Experience

Götherström, Cecilia; Westgren, Magnus; Shaw, Steven W.; Albrecht, Eva; Biswas, Arijit; Byers, Peter H.; Mattar, Citra Nurfarah Zaini; Graham, Gail E.; Taslimi, Jahan; Ewald, Uwe; Fisk, Nicholas M.; Yeoh, Allen Eng Juh; Lin, Jainn-Jim; Cheng, Po Jen; Choolani, Mahesh; Blanc, Katarina Le; Chan, Jerry Kok Yen

doi:10.5966/sctm.2013-0090

Cited by 180 publications

(160 citation statements)

References 44 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…(105) Previous human studies of bone marrow transplantation showed little mesenchymal lineage engraftment and failed to deliver clear benefit, (106,107) but the recent report of fetal stem cell infusion both before and after delivery in a child thought to have type IV OI was encouraging. (108) Ex vivo manipulation of cells and then their reintroduction has been widely discussed after the recent successful treatment of a child with leukemia. In OI, an approach of this type could substantially impact on tissue phenotype.…”

Section: Effects Of Current Interventions In Oimentioning

confidence: 99%

Bone Material Properties in Osteogenesis Imperfecta

Bishop

2016

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Osteogenesis imperfecta entrains changes at every level in bone tissue, from the disorganization of the collagen molecules and mineral platelets within and between collagen fibrils to the macroarchitecture of the whole skeleton. Investigations using an array of sophisticated instruments at multiple scale levels have now determined many aspects of the effect of the disease on the material properties of bone tissue. The brittle nature of bone in osteogenesis imperfecta reflects both increased bone mineralization density-the quantity of mineral in relation to the quantity of matrix within a specific bone volume-and altered matrix-matrix and matrix mineral interactions. Contributions to fracture resistance at multiple scale lengths are discussed, comparing normal and brittle bone. Integrating the available information provides both a better understanding of the effect of current approaches to treatment-largely improved architecture and possibly some macroscale toughening-and indicates potential opportunities for alternative strategies that can influence fracture resistance at longer-length scales.

show abstract

Section: Effects Of Current Interventions In Oimentioning

confidence: 99%

Bone Material Properties in Osteogenesis Imperfecta

Bishop

2016

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Götherström ve ark. [39] 2014 yılında bildirdikleri klinik çalımalarında prenatal ve postnatal olarak ortak donörden alınan MKH retransplantasyonu uygulamılardır. Aratırmacılar 2.8x10 6 hücre/kg olarak uyguladıkları tedavi sonrası düük seviyede kemik engraftmanı, lineer büyüme, kırık ve mobilite de iyileme saptadıklarını bildirmilerdir.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

“…Sonuçlar do¤rultusunda prenatal ve postnatal OI tespit edilen olgulara allojenik MKH retransplantasyonunun güvenilir ve etkili oldu¤unu bildirilmitir. [39] Osteoartrit tedavisinde, allojenik kemik ili¤i kaynaklı MKH'nin denendi¤i bir baka çalımada primer hastalıkları radyolojik bulgularla gösterilmi 30 hasta iki gruba ayrılmı, kontrol grubuna hyaluronik asit (60 mg tek doz), deney grubu hastalarına ise yine eklem içi 40x10 6 MKH uygulanmı. Bir yıl sonraki kontrollerde a¤rı, yaam kalitesi ve hareket kısıtlılı¤ında azalma oldu¤u kaydedilmi.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

View full text Add to dashboard Cite

Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

show abstract

“…The patient co-received vitamin D3, calcium and bisphosphonates. Unfortunately, he died at the age of 5 months as a result of respiratory failure associated with pneumonia [18].…”

Section: Mesenchymal Stem Cells In Regenerative Medicinementioning

confidence: 99%

Application of mesenchymal stem cells in paediatrics

Wawryk‐Gawda

Wójcik

2017

Current Issues in Pharmacy and Medical Sciences

View full text Add to dashboard Cite

Mesenchymal stem cells (MSC) were described by Friedenstein in the 1970s as being a group of bone marrow non-hematopoietic cells that are the source of fibroblasts. Since then, knowledge about the therapeutic potential of MSCs has significantly increased. MSCs are currently used for the treatment of many diseases, both in adults and children. MSCs are used successfully in the case of autoimmune diseases, including rheumatic diseases, diabetes mellitus type 1, gastroenterological and neurological diseases. Moreover, treatment of such organ disorders as damage or hypoxia through application of MSC therapy has shown to be satisfactory. In addition, there are some types of congenital disorders, including osteogenesis imperfecta and Spinal Muscular Atrophy, that may be treated with cellular therapy. Most studies showed no other adverse effects than fever. Our study is an analysis that particularly focuses on the registered trials and results of MSCs application to under 18 patients with acute, chronic, recurrent, resistance and corticosteroids types of Graft-versus-Host Disease (GvHD). Stem cells currently play an important role in the treatment of many diseases. Long-term studies conducted on animals have shown that cell therapy is both effective and safe. The number of indications for use of these cells in the course of treatment of people is constantly increasing. The results of subsequent studies provide important data justifying the application of MSCs in the course of treatment of many diseases whose treatment is ineffective when utilizing other approaches.

show abstract

Pre- and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two-Center Experience

Cited by 180 publications

References 44 publications

Bone Material Properties in Osteogenesis Imperfecta

Bone Material Properties in Osteogenesis Imperfecta

Stem cells; mesenchymal stem cells and current clinical applications

Application of mesenchymal stem cells in paediatrics

Contact Info

Product

Resources

About