Pre- and perinatal factors and incidence of breast cancer in the Black Women’s Health Study

Barber, Lauren E.; Bertrand, Kimberly A.; Rosenberg, Lynn; Battaglia, Tracy A.; Palmer, Julie R.

doi:10.1007/s10552-018-1103-3

Cited by 15 publications

(10 citation statements)

References 62 publications

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“…A positive association between high birthweight studies (from measurements made at birth by medical doctors, birth records/medical registers, maternal interviews, or adult self-report) and an increased risk of breast cancer in adulthood has been observed in most prior studies [2][3][4][5][6][7][8] and confirms our earlier findings from the same . Multivariableadjusted model 2: same as model 1 but with additional adjustment for adult caloric intake (quintiles), adult alcohol intake (quintiles), adult smoking (never, past, current <15 cigarettes/d, current ≥15 cigarettes/d), and adult BMI (<20.9 kg/m 2 , 21-22.9 kg/m 2 , 23-24.9 kg/m 2 , 25-29.9 kg/m 2 , 30-34.9 kg/m 2 , +35 kg/m 2 ).…”

Section: Discussionsupporting

confidence: 88%

“…In prior epidemiologic studies, high birthweight has been associated with greater risk of breast cancer [2][3][4][5][6] , although this is not true for all studies 5,7 . Intrauterine exposure to sex steroid hormones, growth hormone, insulin, insulin-like growth factors (IGF)-1, and IGF-2, and epigenetic variation are potential key pathways linking anthropometric variables in early life to adult breast cancer risk 8 .…”

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confidence: 96%

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Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter

Schmid

Willett

Ding

et al. 2020

Sci Rep

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the intrauterine and early life environments have been linked to the etiology of breast cancer in prior studies. We prospectively examined whether maternal and newborn anthropometric factors as reported by the mother are related to an increased incidence of adult breast cancer in the daughter. We used data from 35,133 mother-daughter dyads of the Nurses' Health Study (NHS) II and the Nurses' Mothers' Cohort Study. In 2001, living mothers of NHS II participants who were free of cancer completed a questionnaire on their pregnancy with the nurse and their nurse daughter's early life experience. During 403,786 years of follow-up, 865 daughters developed incident cases of invasive breast cancer. Nurses with a birthweight of ≥4000 g had a 32% greater risk for breast cancer (multivariable-adjusted hazard ratio (HR) = 1.32, 95% confidence interval (CI) = 1.02-1.71, p-trend = 0.09) compared with those with birthweights of 3000-3499 g. Higher birth length tended to increase risk of premenopausal breast cancer (p for trend = 0.05). We further noted a modest U-shaped relation between maternal weight gain during pregnancy and premenopausal breast cancer incidence in the daughter. Fetal growth may contribute to shaping later life risk for breast cancer, especially prior to menopause.

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Section: Discussionsupporting

confidence: 88%

mentioning

confidence: 96%

Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter

Schmid

Willett

Ding

et al. 2020

Sci Rep

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“…Three SR/meta-analyses (23)(24)(25), 10 cohort studies (26)(27)(28)(29)(30)(31)(32)(33)(34)(35), and nine case-control studies (14,(36)(37)(38)(39)(40)(41)(42)(43) investigated the association between high birth weight and the risk of breast cancer. The three SR, one of high and two of low quality, reported an increase of breast cancer per 500 g increase in birth weight [RR 1.02 (95% CI 1.01-1.03)] (25) and if birth weight was >4,000 g [RR 1.23 (95% CI 1.13-1.24) and RR 1.15 (1.09-1.21)] (23,24).…”

Section: Breast Cancermentioning

confidence: 99%

The Association Between High Birth Weight and Long-Term Outcomes—Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

et al. 2021

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Background: Studies have shown that the prevalence of children born with high birth weight or large for gestational age (LGA) is increasing. This is true for spontaneous pregnancies; however, children born after frozen embryo transfer (FET) as part of assisted reproductive technology (ART) also have an elevated risk. In recent years, the practice of FET has increased rapidly and while the perinatal and obstetric risks are well-studied, less is known about the long-term health consequences.Objective: The aim of this systematic review was to describe the association between high birth weight and LGA on long-term child outcomes.Data Sources: PubMed, Scopus, and Web of Science were searched up to January 2021. Exposure included high birth weight and LGA. Long-term outcome variables included malignancies, psychiatric disorders, cardiovascular disease, and diabetes.Study Selection: Original studies published in English or Scandinavian languages were included. Studies with a control group were included while studies published as abstracts and case reports were excluded.Data Extraction: The methodological quality, in terms of risk of bias, was assessed by pairs of reviewers. Robins-I (www.methods.cochrane.org) was used for risk of bias assessment in original articles. For systematic reviews, AMSTAR (www.amstar.ca) was used. For certainty of evidence, we used the GRADE system. The systematic review followed PRISMA guidelines. When possible, meta-analyses were performed.Results: The search included 11,767 articles out of which 173 met the inclusion criteria and were included in the qualitative analysis, while 63 were included in quantitative synthesis (meta-analyses). High birth weight and/or LGA was associated with low to moderately elevated risks for certain malignancies in childhood, breast cancer, several psychiatric disorders, hypertension in childhood, and type 1 and 2 diabetes.Conclusions: Although the increased risks for adverse outcome in offspring associated with high birth weight and LGA represent serious health effects in childhood and in adulthood, the size of these effects seems moderate. The identified risk association should, however, be taken into account in decisions concerning fresh and frozen ART cycles and is of general importance in view of the increasing prevalence in high birthweight babies.

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“…Among those, the association between birthweight and breast cancer has been attracted much research interest. Although a positive correlation between women's birthweight and breast cancer risk was discovered in some studies (11,12,20,(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), some others failed to replicate such connection or even detected inconsistent correlations in effect direction (13,15,21,22,(33)(34)(35)(36)(37)(38)(39)(40)(41). These inconsistent ndings may be partly due to potential confounding in uences commonly arisen in observational studies, making it di cult to draw a de nitive conclusion on the causal association between birthweight and breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…However, these traditionally established risk factors during women's adult life appear not to adequately interpretate the occurrence pattern of breast cancer. To advance our understanding of disease causes, the relationship between breast cancer and early growth/development, perinatal intrauterine environments has been attracted much attention since 1990s (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Among those, the association between birthweight and breast cancer has been attracted much research interest.…”

Section: Introductionmentioning

confidence: 99%

Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality

Zhang

Qiao

Zhang

et al. 2022

Preprint

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Background Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship remains unknown. Methods Using summary statistics of birthweight (n=264,498 for own birthweight and 179,360 for offspring birthweight) and breast cancer (n=266,081), we assessed the fetal/maternal-specific genetic correlation between them via LDSC and prioritized fetal/maternal-specific pleiotropic genes through MAIUP. Relying on summary statistics we conducted Mendelian randomization (MR) analyses to evaluate the fetal/maternal-specific origin of causal relationship between birthweight, age of menarche, age at menopause and breast cancer. Results With summary statistics we identified a positive genetic correlation between fetal-specific birthweight and breast cancer (rg=0.123 and P=0.013) as well as a negative but insignificant correlation between maternal-specific birthweight and breast cancer (rg=-0.068, P=0.206); and detected 84 pleiotropic genes shared by fetal-specific birthweight and breast cancer, 49 shared by maternal-specific birthweight and breast cancer. We also revealed fetal-specific birthweight indirectly influenced breast cancer risk in adulthood via the path of age of menarche or age at menopause in terms of MR-based mediation analysis. Conclusion This study reveals that shared genetic foundation and causal mediation commonly drive the connection between the two traits, and that fetal/maternal-specific birthweight plays substantially distinct roles in such relationship. However, our work offers little supportive evidence for the fetal origins hypothesis of breast cancer originating in utero.

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Pre- and perinatal factors and incidence of breast cancer in the Black Women’s Health Study

Cited by 15 publications

References 62 publications

Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter

Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter

The Association Between High Birth Weight and Long-Term Outcomes—Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis

Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality

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