Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality
Abstract:Background
Previous studies demonstrated a positive relationship between birthweight and breast cancer; however, inconsistent, sometimes even controversial, observations also emerged, and the nature of such relationship remains unknown.
Methods
Using summary statistics of birthweight (n=264,498 for own birthweight and 179,360 for offspring birthweight) and breast cancer (n=266,081), we assessed the fetal/maternal-specific genetic correlation between them via LDSC and prioritized fetal/maternal-specific pleio… Show more
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