pRb and p16 protein alterations in human oral tumorigenesis

P16 Expression Correlation with Clinicopathological Features of Oral Cavity Squamous Cell Carcinoma Patients in Bali

“…21 Pande et al in 1998 found a significant correlation between tumor progression with tumor stage. However, there are still many differences between the results of studies on the role of p16 in OCSCC.…”

Early Detection of Oral Squamous Cell Carcinoma ( O SCC ) – Role of Genetics: A Literature Review

“…The expression of Rb protein in OSCC has been variably reported. Many studies have reported loss of Rb protein expression, while others have shown elevated levels of its expression [31][32][33][34][35]. Inactivation of the p16 TSG is a common event in various types of cancer and it may be one of the first TSGs to be inactivated in OSCC.…”

“…Inactivation of the p16 TSG is a common event in various types of cancer and it may be one of the first TSGs to be inactivated in OSCC. Inactivation of this gene may have a prognostic relevance [32,33,[35][36][37][38][39][40]. P16 is a member of a family of negative cell cycle regulatory proteins, that inhibits the activity of cyclin D-CDK4⁄ 6 complexes, thereby preventing Rb phosphorylation.…”

P16 Expression in Laryngeal Squamous Cell Carcinoma and its Relationship with Human Papillomavirus

“…Buna karşılık p16 protein ekspresyonunun kaybı, sigara ve alkole bağlı baş-boyun kanserlerinde en sık ve erken görülen bulgudur. 49,55,56 Sigara ve alkolle ilişkili baş-boyun kanserlerinde p16 proteininde azalma ve p53 gen mutasyonu söz konusudur. Oysa HPV ile ilişkili kanserlerde p16 proteininde artış söz konusudur.…”