Praziquantel Release Systems Based on Poly(Butylene Succinate)/Po lyethylene Glycol Nanocomposites

Soares, Dandara Q.P.; Souza, Fernando G.; Freitas, Raissa B.V.; Soares, Vanessa P.; Ferreira, Letícia P.; Ramón, José; Oliveira, Geiza E.

doi:10.2174/2452271601666160922163508

Cited by 9 publications

(5 citation statements)

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“…The hydrophilicity of PBS-PEG copolymers has also been improved by the incorporation of the hydrophilic PEG. These biodegradable PBS-PEG multiblock copolymers with excellent shape memory properties showed great potential for application in medical devices [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hydrophilic Poly(butylene succinate-butylene dilinoleate) (PBS-DLS) Copolymers Containing Poly(Ethylene Glycol) (PEG) of Variable Molecular Weights

Zarei

Fray

2021

Polymers

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Polymeric materials have numerous applications from the industrial to medical fields because of their vast controllable properties. In this study, we aimed to synthesize series of poly(butylene succinate-dilinoleic succinate-ethylene glycol succinate) (PBS-DLS-PEG) copolymers, by two-step polycondensation using a heterogeneous catalyst and a two-step process. PEG of different molecular weights, namely, 1000 g/mol and 6000 g/mol, was used in order to study its effect on the surface and thermal properties. The amount of the PBS hard segment in all copolymers was fixed at 70 wt%, while different ratios between the soft segments (DLS and PEG) were applied. The chemical structure of PBS-DLS-PEG was evaluated using Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. Gel permeation chromatography was used to determine the molecular weight and dispersity index. The results of structural analysis indicate the incorporation of PEG in the macrochain. The physical and thermal properties of the newly synthesized copolymers were also evaluated using water contact angle measurements, differential scanning calorimetry and dynamic thermomechanical analysis. It was found that increasing the amount of PEG of a higher molecular weight increased the surface wettability of the new materials while maintaining their thermal properties. Importantly, the two-step melt polycondensation allowed a direct fabrication of a polymeric filament with a well-controlled diameter directly from the reactor. The obtained results clearly show that the use of two-step polycondensation in the melt allows obtaining novel PBS-DLS-PEG copolymers and creates new opportunities for the controlled processing of these hydrophilic and thermally stable copolymers for 3D printing technology, which is increasingly used in medical techniques.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Hydrophilic Poly(butylene succinate-butylene dilinoleate) (PBS-DLS) Copolymers Containing Poly(Ethylene Glycol) (PEG) of Variable Molecular Weights

Zarei

Fray

2021

Polymers

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“…In recent years, blending PBS with various polymers such as starch, keratin, and polyethylene glycol (PEG) as well as reinforcing PBS with fillers has received considerable interest in biomedical applications, especially in drug delivery [27,[37][38][39]. In general, the drug release depends on the blend composition and blend morphology [27].…”

Section: Polybutylene Succinate (Pbs) Based Materials For Drug Delive...mentioning

confidence: 99%

“…The release rate further improved when the loading of keratin was increased. Soares et al [37] developed a blend of PBS/PEG, and PBS/ PEG reinforced with montmorillonite (MMT) organoclay for the release of praziquantel. The addition of organoclay in a blend enables a controlled release of praziquantel dissolution process by allowing praziquantel to be in a dissolution medium for 72 hours.…”

Section: Polybutylene Succinate (Pbs) Based Materials For Drug Delive...mentioning

confidence: 99%

Recent insight into the biomedical applications of polybutylene succinate and polybutylene succinate-based materials

Mtibe¹,

Muniyasamy²,

Mokhena³

et al. 2023

Express Polym. Lett.

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The development of biodegradable and biocompatible materials to replace non-biodegradable synthetic polymers has received significant interest in biomedical applications. Amongst all biopolymers, polybutylene succinate (PBS) possesses excellent properties, such as biocompatibility, easy processability, biodegradability, non-toxic, good mechanical and thermal properties, which makes it a suitable candidate to replace non-biodegradable synthetic polymers in biomedical applications. This review provides recent advancements, trends, and challenges for the utilization of polybutylene succinate (PBS) and PBS-based materials for biomedical applications, viz. drug delivery, tissue engineering, and biomedical devices. In addition, the design of medical devices from PBS using 3D and 4D printing is also presented. The market analysis, comparison of virgin PBS and synthetic polymer properties, as well as the end of service life, are summarized briefly. The current status, challenges, and future directions are also discussed.

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“…PBS has been used in synthesis studies and production of food packaging [71,72] , biomedical [73,74] and pharmaceutical [75][76][77][78] products, but has gained prominence in the field of green chemistry as one of the most promising aliphatic polyesters due to its thermal properties, good processability, biodegradability, and easy application in composting [79][80][81] . Some authors [82,83] advocate the application of PBS in the environmental area, with research targeting the removal of excess nitrogenous nutrients in effluents, while [45] addressing the physical removal of petroleum from the environment through the use of PBS with magnetic particles.…”

Section: A Specific Case: Poly(butylene Succinate) -Pbsmentioning

confidence: 99%

Advances and perspectives in the use of polymers in the environmental area: a specific case of PBS in bioremediation

et al. 2020

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Biodegradable polymers (e.g. poly(butylene succinate)-PBS) have been used in several sectors such as the environmental area, especially in bioremediation, in biological processes for conversion of pollutants into inorganic compounds. In this study, the foresight methodology for the use of biodegradable polymers, including PBS, reveals a publication rate of approximately 8.74 articles and 30.63 patents per year, between 2005 and 2019. However, the application of PBS, specifically, is still restricted to the environmental area, with only 3.0% of the 1484 works from this period. The results showed a more significant number of papers on the PBS application for synthesis, characterization, and application in the areas of Chemistry, Physics, and Pharmacy. In the area of bioremediation, only three studies related to PBS were found, revealing the lack of research and development to increase the contribution in the area of environmental recovery.

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Praziquantel Release Systems Based on Poly(Butylene Succinate)/Po lyethylene Glycol Nanocomposites

Cited by 9 publications

References 0 publications

Synthesis of Hydrophilic Poly(butylene succinate-butylene dilinoleate) (PBS-DLS) Copolymers Containing Poly(Ethylene Glycol) (PEG) of Variable Molecular Weights

Synthesis of Hydrophilic Poly(butylene succinate-butylene dilinoleate) (PBS-DLS) Copolymers Containing Poly(Ethylene Glycol) (PEG) of Variable Molecular Weights

Recent insight into the biomedical applications of polybutylene succinate and polybutylene succinate-based materials

Advances and perspectives in the use of polymers in the environmental area: a specific case of PBS in bioremediation

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