Recent insight into the biomedical applications of polybutylene succinate and polybutylene succinate-based materials

Abstract

The development of biodegradable and biocompatible materials to replace non-biodegradable synthetic polymers has received significant interest in biomedical applications. Amongst all biopolymers, polybutylene succinate (PBS) possesses excellent properties, such as biocompatibility, easy processability, biodegradability, non-toxic, good mechanical and thermal properties, which makes it a suitable candidate to replace non-biodegradable synthetic polymers in biomedical applications. This review provides recent advancements, trends, and challenges for the utilization of polybutylene succinate (PBS) and PBS-based materials for biomedical applications, viz. drug delivery, tissue engineering, and biomedical devices. In addition, the design of medical devices from PBS using 3D and 4D printing is also presented. The market analysis, comparison of virgin PBS and synthetic polymer properties, as well as the end of service life, are summarized briefly. The current status, challenges, and future directions are also discussed.

Electrospinning: Processes, Structures, and Materials

“…Another notable characteristic of PBS is its compostability, a feature that when combined with its mechanical resistance, ductility, toughness, and impressive impact resistance positions PBS as a promising material for sustainable applications [194]. In recent years, PBS has attracted significant attention in both industrial and scientific fields, especially in the context of preparing electrospun nanofibers for a wide range of applications [195]. Keratin-PBS electrospun mats were fabricated for drug delivery and cell growth scaffolds [196].…”

Green Electrospun Nanofibers for Biomedicine and Biotechnology

“…Firstly, utilizing a renewable biomass source as the monomer improves the overall sustainability. Additionally, the tunable biodegradation reduces long-term toxicity issues [25][26][27][28][29][30][31][32][33][34][35][36][37]. For biomedical applications, PLAs have been utilized as bioresorbable implants, sutures, and tissue engineering scaffolds.…”

Preparation and smoke suppression mechanism of flame‐retardant PBS composites with BNNS@DOPA

“…Phosphorus-based compounds, which exhibit high flame retardancy and low toxicity, have found wide use, [19][20][21] such as ammonium polyphosphate-based expansion systems, [22][23][24] aluminum hypophosphite and aluminum diethyl phosphonate. [25][26][27] However, flame retardants containing phosphorus often lead to a significant accumulation of heat during combustion, which causes increased smoke release. 9,10-Dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) has been discovered to reduce the heat of combustion by absorbing free radicals during combustion.…”

“…Researchers have shown a longstanding interest in modifying PBS to improve its flame resistance. Phosphorus‐based compounds, which exhibit high flame retardancy and low toxicity, have found wide use, 19–21 such as ammonium polyphosphate‐based expansion systems, 22–24 aluminum hypophosphite and aluminum diethyl phosphonate 25–27 . However, flame retardants containing phosphorus often lead to a significant accumulation of heat during combustion, which causes increased smoke release.…”