Pranferin — A new coumarin from the roots of Prangos ferulacea

Abyshev, A. Z.; Denisenko, P. P.; Kostyuchenko, N. P.; Анисимова, О. С.; Ermakov, E. I.; Sheinker, Yu. N.

doi:10.1007/bf00565332

Cited by 4 publications

(4 citation statements)

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“…These plants have various compounds [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] and also the most of them contain phenolic compounds, especially flavonoids. Flavonoids generally have antioxidant potential.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Mavi

Terzi

Ozgen

et al. 2004

Biological & Pharmaceutical Bulletin

110

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Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are various forms of activated oxygen and nitrogen, which include free radicals such as superoxide ions (O 2 · Ϫ ), hydroxyl (OH · ) and nitric oxide radicals (NO · ), as well as non-free-radical species such as hydrogen peroxide (H 2 O 2 ) and nitrous acid (HNO 2 ). [1][2][3] In living organisms ROS and RNS can form in different ways. Normal aerobic respiration, stimulated polymorphonuclear leukocytes and macrophages, and peroxisomes appear to be the main endogenous sources of most of the oxidants produced by cells. [4][5][6] Exogenous sources of free radicals include tobacco smoke, ionising radiation, organic solvents and pesticides.7-10) Free radicals can cause lipid peroxidation in foods that leads to their deterioration. 11)Oxidation does affect not only lipids. ROS and RNS may cause DNA damage that could lead to mutation. 12,13) In addition, ROS and RNS have been implicated in more than 100 diseases, including malaria, acquired immunodeficiency syndrome, heart disease, stroke, arteriosclerosis, diabetes and cancer.6,14-16) When produced in excess, ROS can cause tissue injury, whilst, tissue injury can itself cause ROS generation.12) Nevertheless, all aerobic organisms, including human beings, have antioxidant defenses that protect against oxidative damage and numerous damage removal and repair enzymes to remove or repair damaged molecules. 8,[17][18][19] However, the natural antioxidant mechanisms can be inefficient, hence dietary intake of antioxidant compounds becomes important. 5,16,20,21) Although there are some synthetic antioxidant compounds, such as butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which are commonly used in processed foods, it has been reported that these compounds may have side effects. [22][23][24][25][26][27][28] In addition, it has been suggested that there is an inverse relationship between dietary intake of antioxidant-rich foods and the incidence of a number of human diseases. 29,30) Therefore, research into the determination of natural antioxidant sources is important.In this study, it is aimed to determine the antioxidant activity (AA) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (DPPH-RSA), reducing powers (RP) and amount of total phenolic compounds (APC) of the some medicinal plants which have been used especially in Eastern Turkey. (AEF 21172). Activity studies were performed on decoctions (5%) and/or methanolic extracts (5%) of used parts of plants in the treatment. Extraction solvents and parts of plants were chosen by taking consideration the usage form of plants by public. Methanol extract was evaporated and then lyophilized, water extract was directly lyophilized. In the AA and DPPH-RSA studies, different concentration ranges were studied and data of 50, 100, 250 and 500 mg/l concentrations were given in all figures. MATERIALS AND METHODS Collection of Plants, Identification and ExtractionDetermination of Antioxidant Properties The in vitro antioxidant activit...

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Section: Discussionmentioning

confidence: 99%

Antioxidant Properties of Some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum sempervivoides (Crassulaceae), Malva neglecta (Malvaceae), Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum subsp. verum (Rubiaceae), Urtica dioica (Urticaceae)

Mavi

Terzi

Ozgen

et al. 2004

Biological & Pharmaceutical Bulletin

110

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“…This extract showed a significant AChE inhibitory activity, with 75.6 % inhibition at a concentration of 50 µg/mL. A further bio-assay-guided fractionation showed that the fraction containing imperatorin (24), oxy-peucedanin (34), oxypeucedanin hydrate (35), oroserol (37), rivulobirin A (39), quercetin (40), and quercetin 3-O-glucuronide (44) was the most active against AChE, showing an IC 50 value of 25.2 µg/mL as well as good docking scores of its constituents [22].…”

Section: Other Propertiesmentioning

confidence: 95%

“…Another common feature in most of the coumarin-based structures is the presence of a prenyl group, variedly oxidized, that can be linked to a carbon atom of the skeleton (4)(5)(6)(7)(8)(9)(10)(11)(12) or to an oxygen atom (13,(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)39). The oxidative ring closure of the prenyl group with a close oxygen results in the formation of hydroxyisopropylfuran moiety (20-23, 37, 38).…”

Section: Occurrencementioning

confidence: 99%

The Nonvolatile and Volatile Metabolites of Prangos ferulacea and Their Biological Properties

et al. 2019

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Prangos ferulacea (L.) Lindl. (Fam. Apiaceae), an orophilous species of eastern Mediterranean and western Asia, possesses a number of biological properties that are worthy of exploitation in different fields. Phytochemical investigations revealed the presence of coumarins, prenyl-coumarins, and furano-coumarins as the main constituents of this species, as well as several flavonoids. Among prenyl-coumarins, osthol is a promising apoptotic agent quite selective toward cancer cells. In addition, the essential oils have been extensively investigated, and several chemotypes have been identified. This work reviews the literature on this species published between 1965 and 2018, describes its volatile and nonvolatile metabolites, and outlines its pharmacological effects.

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“…35, 70,71 have also been isolated from higher plants. 72 tert-Butyl ethers such as 36 73 and bryostatin 14 74 (a pivalic acid ester like neristatin) illustrate the structural and functional diversity of tert-butyl-containing natural products. In total, almost 300 compounds belonging to a few structural families have been isolated from natural sources.…”

Section: The Tert-butyl Group In Naturementioning

confidence: 99%