Prämunition der Lepra

Bechelli, L. M.

doi:10.1007/978-3-642-87077-4_2

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…This difference may be explained by the fact that 4-year-old children had been included in our study and that as shown by above authors, there exists a correlation between the age and lepromin reactivity; namely the reactions significantly intensifies with age, even within months. Unvaccinated children, as they grow older, tend to have a spontaneous increase in the proportion and degree of reactivity to lepromin (Souza Campos et al (9); Bechelli et al (2). In some studies (Paula Souza et al (7)) the conversion of the lepromin reactions from negative to positive was found to be similar in the BCG vaccinated and the non-vaccinated school children.…”

Section: Discussionmentioning

confidence: 91%

“…effect of ~revious ex~osure to mvcobacterial Studies on the possible use of Bacillus Calmette-GuCrin (BCG) for prevention of leprosy revealed that BCG caused up to 80% conversion of the late lepromin reaction (2), but the epidemiological field trials were inconclusive in respect of the protection against leprosy (1)(2)(3)8). In fact, the data obtained from extensive studies ~erformed in Burma and Karimui were ODDOsitely different from those obtained in uga;da (WHO Expert Committee on Leprosy (1 1)).…”

Section: Introductionmentioning

confidence: 99%

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Impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, Mycobacterium leprae

Kwapinski¹,

Bechelli²,

Haddad³

et al. 1975

Can. J. Microbiol.

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Three hundred and twenty young children were injected with Bacillus Calmette-Guerin (BCG) saline, or with one of the mycobacterial cytoplasmic antigens related with Mycobacterium leprae. At an appropriate time thereafter they were tested for dermal hypersensitivity to the antigens and for reactions to lepromin. Whereas all the antigens induced cell-mediated immunity, the incidence and intensity of late response to lepromin were significantly reduced in children preinjected with the cytoplasmic mycobacterial antigens, as contrasted with increased lepromin reactivity in the BCG group and with the findings in saline-injected children.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, Mycobacterium leprae

Kwapinski¹,

Bechelli²,

Haddad³

et al. 1975

Can. J. Microbiol.

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“…Such increase could also be explained by a change in the transmissibility risk in cohort groups 20 , which is rather unlikely because of the actual increase of rates in older age groups. Tuberculoid form detection rates being higher in women than in man 1,2,6,31 during the studied period may be due to the women's demand for health services and their increased participation in the work market during the above-mentioned period, thereby making exposure possibilities being alike for both men and women.…”

Section: -Discussion and Conclusionmentioning

confidence: 93%

Leprosy spread in urban area: part I: epidemiological characteristics of an endemic urban area for leprosy: the county of São Gonçalo, Rio de Janeiro state, Brazil

ANDRADE,

SABROZA,

CASTROS

et al. 1990

Hansen. Int.

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Among the needs of deepening the epidemiological inquiry studies of leprosy diffusion in urban area, the evaluation of the Local Information System stands out as base instrument to carry out an epidemiological and operational analysis. The information system was utilized also as base to the populational planning studies. In the present paper, the achievement of the recorded cases mapping in three sanitary units in respective copyhold sectors, as well as the analysis of the specific epidemiological and operational indicators, permited the characterization of the São Gonçalo county as urban endemic area for leprosy, the delimitation of the foci and the inquiry planning. Starting with the specific indicators, according to age, sex, clinical form in the case register date, it was verified a higher detection rate in women than in men, as well as an increase of the tendency of the tuberculoid forms. In the epidemiological inquiry conducted during 85 days, 926 dwellings were visited with interview, physical examination, anthropometric measurings and soluble antigen (SA) application. Such inquiry was conducted by a staff of health professionals and specially trainned and standardized community members. The produced results confirmed that in the copyhold sectors without registered cases, no case, was found and that the domiciliary visits during the Sunday do not presented a superior productivity to the allover days of the week. The whole of the findings lead oneself to conclude that the Local Information System is a valuable instrument for the description of the endemic characteristics in this county and file a construction adequate to the planning of populational studies.

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“…Bechelli et. al 7 propuseram um método para estimar os casos não detectados de hanseníase, baseado em dados do Grupo Consultor da Organização Mundial da Saúde que, se o programa de controle da endemia em dada região se revelava como satisfatório, regular ou precá-rio, adiciona-se fator corretivo ao número de casos registrados, respectivamente de 75%, 150% e 300%. Opromolla et al 8 realizaram estimativa da prevalência da hanseníase pela investigação em demanda inespecífica de unidades de saúde 8 .…”

Section: Discussionunclassified

Aplicação de métodos de estimativa da prevalência de hanseníase no Estado de Mato Grosso

Ignotti

Rodrigues

Andrade

et al. 2004

Rev. bras. epidemiol.

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Uma questão desafiadora para a eliminação da hanseníase como problema de saúde pública é o conhecimento da sua real prevalência. Este estudo tem por objetivo comparar os resultados de dois métodos publicados como propostas de estimativa de prevalência oculta de hanseníase, a tendência definida pelo Ministério da Saúde, e a estimativa realizada pela Secretaria de Estado de Saúde de Mato Grosso (SES/MT) para a implantação do programa "Tolerância Zero: Mato Grosso sem hanseníase", tendo como parâmetro o número de casos novos detectados em 2001. Fez-se a aplicação dos métodos e da tendência, utilizando-se a série de casos de hanseníase detectados no período de 1996 a 2000 para todos os municípios do Estado. Definiu-se como nível endêmico a média aritmética ajustada aos casos novos detectados no mesmo período. Verificou-se que todas as estimativas mostraram associação positiva maior que 75% com o número de casos detectados em 2001. A maior associação foi verificada entre a meta ou estimativa da SES/MT (r²=0,895), que por outro lado não é observada com a exclusão do nível endêmico. Concluímos que os métodos publicados apenas sugerem a presença de reservatórios de casos em áreas com detecção tardia. Operacionalmente, parece mais adequado basear-se em séries históricas segundo idade, classificação operacional, grau de incapacidade física e número de lesões no momento do diagnóstico para a identificação de áreas de risco e, conseqüentemente, eliminação da hanseníase.

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Prämunition der Lepra

Cited by 4 publications

References 11 publications

Impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, Mycobacterium leprae

Impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, Mycobacterium leprae

Leprosy spread in urban area: part I: epidemiological characteristics of an endemic urban area for leprosy: the county of São Gonçalo, Rio de Janeiro state, Brazil

Aplicação de métodos de estimativa da prevalência de hanseníase no Estado de Mato Grosso

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