Pramipexole Protects Spinal Motor Neuron Death Against Glutamate-Induced Neurotoxicity

Kano,

doi:10.4021/jnr61w

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Pramipexole Amantadine Benzodiazepines Trazodone1

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2019

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“…Pramipexole has neuroprotective effect against glutamate-induced neurotoxicity [84]. Amantadine leads to recovery and decreases dopamine-release deficits in TBI patients [85,86].…”

Section: Pramipexole Amantadine Benzodiazepines Trazodonementioning

confidence: 99%

Psychotropics and Neuroprotection: Literature Review and Case Series Report

Meresh¹,

Daniels²,

Owens³

et al. 2019

obm neurobiol

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Agitation is a common manifestation of acute brain injury. When not addressed, agitation can lead to slower recovery rates, including delayed admission to acute rehabilitation programs. Antipsychotics are commonly used to control agitation in acute brain injury in the ICU. However, there is no current consensus on the most "efficacious and safest strategy" for use of antipsychotics in acute TBI. Haloperidol is arguably the commonly used antipsychotic for agitation in ICU setting at present. Interestingly, there are no studies to our knowledge that assess for haloperidol use in TBI patient's specifically. Further, there are some concerns with the use of Haloperidol given that it does not offer a neuroprotective effect and may have some adverse effects that are particularly harmful for this population. In this paper, we offer a review of alternate medications that may be more appropriate for the treatment of

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“…Pramipexole has neuroprotective effect against glutamate-induced neurotoxicity [84]. Amantadine leads to recovery and decreases dopamine-release deficits in TBI patients [85,86].…”

Section: Pramipexole Amantadine Benzodiazepines Trazodonementioning

confidence: 99%